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anti-Mouse (Murine) GADD45A Antikörper:
anti-Human GADD45A Antikörper:
anti-Rat (Rattus) GADD45A Antikörper:
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Human Monoclonal GADD45A Primary Antibody für PLA, ELISA - ABIN560584
Al-Romaih, Sadikovic, Yoshimoto, Wang, Zielenska, Squire: Decitabine-induced demethylation of 5' CpG island in GADD45A leads to apoptosis in osteosarcoma cells. in Neoplasia (New York, N.Y.) 2008
Show all 2 Pubmed References
Human Polyclonal GADD45A Primary Antibody für IF (p), IHC (p) - ABIN685432
Yuan, Han, Cong, Ge, Ma, Dai, Li, Bi: Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity. in International journal of nanomedicine 2014
Human Polyclonal GADD45A Primary Antibody für FACS, WB - ABIN650724
Li, Morales, Hwang, Wagner, Boothman: DNA mismatch repair-dependent activation of c-Abl/p73alpha/GADD45alpha-mediated apoptosis. in The Journal of biological chemistry 2008
Show all 5 Pubmed References
Gadd45a and Gadd45g (zeige GADD45G Antikörper) regulate neural development and exit from pluripotency in Xenopus.
Results provide evidence for a coupled mechanism of 5-methylcytosine (5-meC (zeige CCL28 Antikörper)) demethylation, whereby 5-meC (zeige CCL28 Antikörper) deaminase (AID) deaminates 5-meC (zeige CCL28 Antikörper), followed by thymine base excision by G:T mismatch-specific thymine glycosylase (Mbd4 (zeige MBD4 Antikörper)), promoted by Gadd45.
GADD45A gene variants are associated with meat quality in pigs.
Gadd45a relaxes the promoter regions of miR (zeige MLXIP Antikörper)-295 and promotes the expression of miR (zeige MLXIP Antikörper)-295 during reprogramming, implying a concise mechanism of Gadd45a and miR (zeige MLXIP Antikörper)-290 cluster cooperation in cell-fate determination.
Retinoic acid inhibits white adipogenesis by inducing retinoic acid receptor (zeige RARA Antikörper) and ING1 (zeige ING1 Antikörper) interaction and inhibiting Gadd45a expression, which prevents GADD45A-mediated DNA demethylation.
identifed Gadd45a as a chromatin relaxer in embryonic fibroblasts, which also enhances somatic cell reprogramming efficiency; showed that residue glycine 39 in Gadd45a is essential for interacting with core histones, opening chromatin and enhancing reprogramming. demonstrateed that Gadd45a destabilizes histone-DNA interactions and facilitates binding of Yamanaka factors to their targets for activation
Data show that loss of growth arrest and DNA-damage-inducible 45 alpha protein (Gadd45a) accelerates the onset of BCR-ABL driven leukemia in bone marrow recipient mice.
by forming a complex with MEKK4 (zeige MAP3K4 Antikörper) in skeletal muscle fibers, Gadd45a increases MEKK4 (zeige MAP3K4 Antikörper) protein kinase (zeige CDK7 Antikörper) activity, which is both sufficient to induce skeletal muscle fiber atrophy and required for Gadd45a-mediated skeletal muscle fiber atrophy.
Gadd45a may counteract hepatic fi brosis by regulating the activation of hepatic stellate cells via the inhibition of TGF-beta (zeige TGFB1 Antikörper)/Smad (zeige SMAD1 Antikörper) signaling.
These data indicate that genotoxic stress-induced GADD45A expression in HSCs prevents their fatal transformation by directing them into differentiation and thereby clearing them from the system
provide the novel evidence that GADD45A inhibits autophagy via impairing the BECN1 (zeige BECN1 Antikörper)-PIK3C3 (zeige PIK3C3 Antikörper) complex formation
Results suggest the possibility that differential Gadd45a, Gadd45b (zeige GADD45B Antikörper) and Gadd45g (zeige GADD45G Antikörper) expression during development affects neurons, contributing cortical evolution and diversity
GADD45a promoter regulation by a functional genetic variant is associated with acute mechanical lung injury.
Human miR (zeige MLXIP Antikörper)-374 induces apoptosis and inhibits proliferation, migration, and invasion of human squamous carcinoma cells through P53 (zeige TP53 Antikörper) signaling pathway by down-regulating Gadd45a.
Findings demonstrated that miR (zeige MLXIP Antikörper)-148a promotes glioma cell invasion and tumorigenesis by downregulating GADD45A. Findings provide novel insights into how GADD45A is downregulated by miR (zeige MLXIP Antikörper)-148a in IDH1R132H glioma
A mechanism in which GADD45a is required for demethylation of the MMP-9 (zeige MMP9 Antikörper) promoter and the induction of diabetic wound healing. The inhibition of GADD45a might be a therapeutic strategy for diabetic foot ulcers.
present study provides evidence that variations in GADD45B (zeige GADD45B Antikörper) rs2024144T, MAPK14 (zeige MAPK14 Antikörper) rs3804451A and GADD45A rs581000C may predict platinum-based chemotherapy toxicity outcomes in patients with advanced non-small cell lung cancer
Our findings indicate that GADD45 essentially suppresses the MKK7 (zeige MAP2K7 Antikörper)-JNK (zeige MAPK8 Antikörper) pathway and suggest that differentially expressed GADD45 family members fine-tune stress-inducible JNK (zeige MAPK8 Antikörper) activity.
Stimulation of ribosomal RNA gene promoter by transcription factor Sp1 (zeige SP1 Antikörper) involves active DNA demethylation by Gadd45-NER (zeige NR1H2 Antikörper) pathway.
The findings indicate that p38alpha (zeige MAPK14 Antikörper) and GADD45alpha are involved in an enhanced vitamin D signaling on TRPV6 (zeige TRPV6 Antikörper) expression.
the enhancement of GADD45A-mediated base excision repair modulated by ATF2 (zeige ATF2 Antikörper) might be a potential protective mechanism of visible red light.
Data show that growth arrest and DNA-damage-inducible 45 alpha protein (Gadd45a) expression is up-regulated in chronic phase myelocytic leukemia, chronic (CML) patient samples but down-regulated in accelerated and blast crisis phase samples.
These data revealed that Riboflavin plus ultraviolet (UV) pathogen reduction technology effectively inhibited proliferation and induced apoptosis of lymphocytes by promoting GADD45alpha expression, which subsequently activates p38 (zeige CRK Antikörper) and JNK (zeige MAPK8 Antikörper) signaling pathways.
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
growth arrest and DNA-damage-inducible, alpha
, growth arrest and DNA damage-inducible protein GADD45 alpha
, growth arrest and DNA-damage-inducible protein 45 alpha
, growth arrest and DNA-damage-inducible protein alpha
, growth arrest and DNA damage-inducible protein 45
, Growth arrest and DNA-damage-inducible protein GADD45 alpha
, DNA damage-inducible transcript 1 protein
, DNA-damage inducible transcript 1
, DNA-damage-inducible transcript 1
, growth arrest and DNA-damage-inducible protein GADD45 alpha
, DNA damage-inducible transcript-1
, growth arrest and DNA-damage-inducible 45 alpha