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Human CDKN1A Protein expressed in HEK-293 Cells - ABIN2713874
Porter, Farmaki, Altilia, Schools, West, Chen, Chang, Puzyrev, Lim, Rokow-Kittell, Friedhoff, Papavassiliou, Kalurupalle, Hurteau, Shi, Baran, Gyorffy, Wentland, Broude, Kiaris, Roninson: Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. in Proceedings of the National Academy of Sciences of the United States of America 2012
We characterized the effect of the novel loci through pathway analysis and found that pathways involved are not entirely distinct as assumed so far. Further, we identified a novel association between CDKN1A and POAG. Using a zebrafish model we show that six6b (associated with POAG and optic nerve head variation) alters the expression of cdkn1a
intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (zeige CDK1 Proteine), wee1 (zeige WEE1 Proteine), p21, PCNA (zeige PCNA Proteine) and cdk2 (zeige CDK2 Proteine), but only weakly influences cyclin B1 (zeige CCNB1 Proteine), cyclin B2 (zeige CCNB2 Proteine) and cyclin E1 (zeige CCNE1 Proteine) expression.
High CDKN1A expression is associated with migration, invasion, and progression of bladder cancer.
CDKN1A role in DANCR-mediated tumor cell growth.
CDKN1A expression was seen only in five cases and that too focally in the cytoplasm, thereby warranting removal of analysis of CDKN1A positivity from the study
Results show that knockdown of GABPB1 in clear cell renal cell carcinoma (zeige MOK Proteine) cell lines significantly decreased the ability to form colonies by inducing the expression of p21Waf/Cip1.
Authors demonstrate that HMGB2 transcription is repressed by p21 during radiation-induced senescence through the ATM-p53-p21 DNA damage signaling cascade. The loss of p21 abolished the downregulation of HMGB2 caused by ionizing radiation, and the conditional induction of p21 was sufficient to repress the transcription of HMGB2.
Low CDKN1A expression is associated with cervical cancer.
p21 was involved in glioma cell proliferation after SNHG6 was downregulated.
overexpressed PKM2 (zeige PKM Proteine) led to increased CCND1 (zeige CCND1 Proteine) and decreased CDKN1A expression, whereas underexpressed PKM2 (zeige PKM Proteine) led to decreased CCND1 (zeige CCND1 Proteine) and increased CDKN1A expression in ovarian cancer cells.
the CDK (zeige CDK4 Proteine) inhibitor p21 begins rising in G2 in mother cells whose daughters exit mitosis into the pre-Restriction Point, CDK2 (zeige CDK2 Proteine)(low) state. Furthermore, degradation of p21 coincides with escape from the CDK2 (zeige CDK2 Proteine)(low) state and passage through the Restriction Point.
SAC (zeige ADCY10 Proteine) decreased the levels of 5-methylcytosine, DNMT (zeige DNMT1 Proteine) activity, messenger RNA (mRNA) and protein levels of DNMT1 (zeige DNMT1 Proteine). Additionally, SAC (zeige ADCY10 Proteine) treatment resulted in re-expression of the mRNA and proteins of silenced tumor suppressor gene CDKN1A accompany with reduced cell division control 2 (zeige CDK1 Proteine) expression.
p21 expression reports on Bovine herpesvirus 4 replication and could represent a host cell defensive response to infection-associated cellular damage.
Study reveal that p16Ink4a and p21Waf1/Cip1 upregulate CX3CR1 (zeige CX3CR1 Proteine) expression by preventing CDK (zeige CDK4 Proteine)-mediated phosphorylation and inactivation of SMAD3 (zeige SMAD3 Proteine) in monocytic myeloid-derived suppressor cells promoting tumor growth through chemotaxis.
while muCT analysis indicates that p21(-/-) mice have enhanced bone healing capabilities, differences observed may not be due to the function of osteoblasts or osteoclasts
the deletion of Cdkn1a in vivo results in an elevated level of cell proliferation but not cell death.
p21 plays a relevant role in fasting adaptation through the positive regulation of PPARalpha (zeige PPARA Proteine).
The results suggested that TAZ (zeige TAZ Proteine) may suppress apoptosis and premature senescence in spermatogenic cells by inhibiting the p53 (zeige TP53 Proteine)-p21 signaling pathway, thus playing important roles in the maintenance and control of reproductive function.
Results identify endoplasmic reticulum stress as an age-dependent modifier of islet survival and function by mechanisms implicating enhancement of CHOP (zeige DDIT3 Proteine) activity and inhibition of the protective activity of p21.
Specifically, the proteins p18INK4C (zeige CDKN2C Proteine), p21CIP1 and p27KIP1 (zeige CDKN1B Proteine) seem to play an outstanding role in the maintenance of the differentiated state of adipocytes.
Collectively, our findings demonstrate that PCAT-1 is a new candidate for use in OS diagnosis, prognosis and therapy.
results indicated that p21-deficient DMM (zeige COL2A1 Proteine) mice were susceptible to alterations in Osteoarthritis (OA) phenotype, including enhanced osteoclast expression, macrophage infiltration, and MMP expression through IL-1beta (zeige IL1B Proteine)-induced NF-kappaB (zeige NFKB1 Proteine) signaling, suggesting that p21 regulation may constitute a possible therapeutic strategy for OA treatment.
our genetic and biochemical data show an important function of p21 in the regulation of growth-related processes in the heart.
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.
cyclin dependent kinase inhibitor p16Xic2
, cyclin-dependent kinase inhibitor 1
, cyclin D1
, cyclin-dependent kinase inhibitor 1A (p21, Cip1)
, cyclin-dependent kinase inhibitor 1A
, cyclin-dependent kinase inhibitor 1A (P21)
, CDK-interacting protein 1
, CDK-interaction protein 1
, DNA synthesis inhibitor
, melanoma differentiation associated protein 6
, wild-type p53-activated fragment 1
, melanoma differentiation-associated protein