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Human CDKN1A Protein expressed in HEK-293 Cells - ABIN2713874
Porter, Farmaki, Altilia, Schools, West, Chen, Chang, Puzyrev, Lim, Rokow-Kittell, Friedhoff, Papavassiliou, Kalurupalle, Hurteau, Shi, Baran, Gyorffy, Wentland, Broude, Kiaris, Roninson: Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. in Proceedings of the National Academy of Sciences of the United States of America 2012
We characterized the effect of the novel loci through pathway analysis and found that pathways involved are not entirely distinct as assumed so far. Further, we identified a novel association between CDKN1A and POAG. Using a zebrafish model we show that six6b (associated with POAG and optic nerve head variation) alters the expression of cdkn1a
intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (zeige CDK1 Proteine), wee1 (zeige WEE1 Proteine), p21, PCNA (zeige PCNA Proteine) and cdk2 (zeige CDK2 Proteine), but only weakly influences cyclin B1 (zeige CCNB1 Proteine), cyclin B2 (zeige CCNB2 Proteine) and cyclin E1 (zeige CCNE1 Proteine) expression.
SAC (zeige ADCY10 Proteine) decreased the levels of 5-methylcytosine, DNMT (zeige DNMT1 Proteine) activity, messenger RNA (mRNA) and protein levels of DNMT1 (zeige DNMT1 Proteine). Additionally, SAC (zeige ADCY10 Proteine) treatment resulted in re-expression of the mRNA and proteins of silenced tumor suppressor gene CDKN1A accompany with reduced cell division control 2 (zeige CDK1 Proteine) expression.
Down-regulation of HOTAIR elicits an inhibitory effect on proliferation, invasion, and migration, while promoting the apoptosis of colorectal cancer cells through the up-regulation of p21.
Glutaredoxin-1 silencing induces cell senescence via p53/p21/p16 signaling axis.
p16, p21, and p53 (zeige TP53 Proteine) proteins play an important role in the deregulation of the cell cycle and participate in the development of pancreatic intraepithelial neoplasia.
Here, the authors demonstrated that CUL4B (zeige CUL4B Proteine) forms an E3 ligase with RBX1 (RING-box 1), DDB1 (DNA damage binding protein 1), and DCAF11 (DDB1 and CUL4 associated factor 11 (zeige DCAF11 Proteine)) that promotes the ubiquitination of p21(Cip1) and regulates cell cycle progression in human osteosarcoma cells.
Low CIP1 expression is associated with gastric cancer.
PAK1 (zeige PAK1 Proteine) is upregulated in cutaneous T cell lymphoma. PAK1 (zeige PAK1 Proteine) silencing induced apoptosis and inhibited cell growth by stimulating the expression of PUMA (zeige BBC3 Proteine) and p21.
SNAP23 (zeige SNAP23 Proteine) suppressed progression of cervical cancer and induced cell cycle G2/M arrest via upregulating p21(cip1) and downregulating CyclinB1
These findings reveal an important mechanism by which p21 can be stabilized by direct deubiquitylation, and they pinpoint a crucial role of the USP11 (zeige USP11 Proteine)-p21 axis in regulating cell-cycle progression and DNA damage responses.
Polymorphisms in TP53 (zeige TP53 Proteine) and P21 proteins are associated with an increased risk of stomach cancer.
p21 expression reports on Bovine herpesvirus 4 replication and could represent a host cell defensive response to infection-associated cellular damage.
while muCT analysis indicates that p21(-/-) mice have enhanced bone healing capabilities, differences observed may not be due to the function of osteoblasts or osteoclasts
the deletion of Cdkn1a in vivo results in an elevated level of cell proliferation but not cell death.
p21 plays a relevant role in fasting adaptation through the positive regulation of PPARalpha (zeige PPARA Proteine).
The results suggested that TAZ (zeige TAZ Proteine) may suppress apoptosis and premature senescence in spermatogenic cells by inhibiting the p53 (zeige TP53 Proteine)-p21 signaling pathway, thus playing important roles in the maintenance and control of reproductive function.
Results identify endoplasmic reticulum stress as an age-dependent modifier of islet survival and function by mechanisms implicating enhancement of CHOP (zeige DDIT3 Proteine) activity and inhibition of the protective activity of p21.
Specifically, the proteins p18INK4C (zeige CDKN2C Proteine), p21CIP1 and p27KIP1 (zeige CDKN1B Proteine) seem to play an outstanding role in the maintenance of the differentiated state of adipocytes.
Collectively, our findings demonstrate that PCAT-1 is a new candidate for use in OS diagnosis, prognosis and therapy.
results indicated that p21-deficient DMM (zeige COL2A1 Proteine) mice were susceptible to alterations in Osteoarthritis (OA) phenotype, including enhanced osteoclast expression, macrophage infiltration, and MMP expression through IL-1beta (zeige IL1B Proteine)-induced NF-kappaB (zeige NFKB1 Proteine) signaling, suggesting that p21 regulation may constitute a possible therapeutic strategy for OA treatment.
our genetic and biochemical data show an important function of p21 in the regulation of growth-related processes in the heart.
The Smad3 (zeige SMAD3 Proteine) and Bmal1 (zeige ARNTL Proteine) regulate p21 and S100A4 (zeige S100A4 Proteine) expression in myocardial stromal fibroblasts through TNF-alpha (zeige TNF Proteine).
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.
cyclin dependent kinase inhibitor p16Xic2
, cyclin-dependent kinase inhibitor 1
, cyclin D1
, cyclin-dependent kinase inhibitor 1A (p21, Cip1)
, cyclin-dependent kinase inhibitor 1A
, cyclin-dependent kinase inhibitor 1A (P21)
, CDK-interacting protein 1
, CDK-interaction protein 1
, DNA synthesis inhibitor
, melanoma differentiation associated protein 6
, wild-type p53-activated fragment 1
, melanoma differentiation-associated protein