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Human Polyclonal THRB Primary Antibody für IHC, ELISA - ABIN1579929
Wang, Wei, Guan, Xue: Triiodothyronine regulates distribution of thyroid hormone receptors by activating AMP-activated protein kinase in 3T3-L1 adipocytes and induces uncoupling protein-1 expression. in Molecular and cellular biochemistry 2014
Zebrafish (Danio rerio) Polyclonal THRB Primary Antibody für ELISA, WB - ABIN408742
Liu, Chan: Thyroid hormones are important for embryonic to larval transitory phase in zebrafish. in Differentiation; research in biological diversity 2002
Using domain exchanges and individual amino acid switches between THRA1 (zeige THRA Antikörper) and THRB2, three amino acids were identified in helix 10 of the THRB2 ligand-binding domain that are required for negative regulation and are absent in THRA1 (zeige THRA Antikörper).
Data suggest a novel role for THRbeta1 in secondary ossification at the epiphysis that involves transcriptional upregulation of Ihh (zeige IHH Antikörper) gene.
In thyroid receptor-deficient mice, hair follicle stem cells present a clear defect in their mobilization (exit of their quiescent state and migration out of the niche), associated with increased activation of Smad (zeige SMAD1 Antikörper) signaling.
Data show that TRbeta deficiency causes dysfunction of the monoaminergic system, accompanied by epigenetic disruption during the brain maturation process.
Results suggest mutually shared roles for thyroid hormone receptor beta isoforms TRbeta1 and TRbeta2 in cochlear development.
Our findings indicated that synergistic signaling of KRAS(G12D) and TRbetaPV led to increased MYC (zeige MYC Antikörper) expression.
T3 induces FGF21 (zeige FGF21 Antikörper) in cultured hepatocytes and this effect involves direct actions of TRbeta1, which binds a TRE (zeige TREH Antikörper) within intron 2 of FGF21 (zeige FGF21 Antikörper). But T3 induced most gene expression in liver independently of FGF21 (zeige FGF21 Antikörper).
TRbeta acts as a cytoplasmic, phosphotyrosine-dependent scaffold for the p85 (zeige ECM1 Antikörper) regulatory subunit of PI3K and the Src kinase (zeige CSK Antikörper) Lyn (zeige LYN Antikörper) in the absence of thyroid hormone (zeige PTH Antikörper).
TRbeta-related deafness originates outside of hair cells and that TRalpha (zeige GNAT1 Antikörper) and TRbeta play opposing, non-redundant roles in hair cells.
Luciferase expression driven by the midwavelength sensitive opsin intron 3-4 region was only slightly increased by THRB2, and rather enhanced by COUP-TFII (zeige NR2F2 Antikörper).
Data provide evidence that zebrafish represents a valid model to study in vivo the thyroid hormone (zeige PTH Antikörper) (TH) action, and the molecular mechanisms underlying the two syndromes of TH resistance, RTHa and RTHb.
Data suggest that the embryonic to larval transitory phase is characterized by its dependency on the timely synthesis of thyroid hormone (zeige PTH Antikörper) and the concomitant autoinductive increase in thyroid hormone receptor beta mRNA levels.
Authors previously shown that Nuclear Receptor Corepressor 1 (NCoR (zeige NCOR1 Antikörper)) and the thyroid hormone receptor (zeige THRA Antikörper) beta1 (TRbeta (zeige TXNRD2 Antikörper)) inhibit tumor invasion. Here they show that these molecules repress VEGF-C (zeige VEGFC Antikörper) and VEGF-D (zeige Figf Antikörper) gene transcription in breast cancer cells, reducing lymphatic vessel density and sentinel lymph node invasion in tumor xenografts.
The results emphasized the importance of TRB1 (zeige TRIB1 Antikörper) in the regulation of HSV-1 replication in differentiated environment with neuronal phenotype.
In certain contexts, Rb loss enables TRbeta1-dependent suppression of SKP2 as a safeguard against RB1 (zeige RB1 Antikörper)-deficient tumorigenesis. TRbeta2 counteracts TRbeta1, thus disrupting this safeguard and promoting development of RB1 (zeige RB1 Antikörper)-deficient malignancies.
A relatively stable genome in retinoblastoma tumor cells is maintained by TRb1 (zeige TRIB1 Antikörper) and TRb2 (zeige TRIB2 Antikörper)-mediated PTTG1 (zeige PTTG1 Antikörper) inhibition, counteracting Rb-deficiency-related genomic instability.
the actions of R429Q-TRbeta1 in Resistance to Thyroid Hormone (RTH)-Syndrome most likely reflect the reduced hormone affinity observed for this mutant rather than an alteration in target gene repertoire.
The present studies uncovered a novel mechanism by which thyroid hormone receptor beta could function as a tumor suppressor through modulation of TNF alpha-IkappaB alpha-NFkappaB pathway.
Novel THRB single nucleotide substitution-C to G in codon 340 in resistance to thyroid hormone (zeige PTH Antikörper) syndrome.
THRA (zeige THRA Antikörper) predominates in multipotent human adipose derived stem cells (hADSC) whereas THRB is expressed at lower levels and is upregulated during hADSC differentiation.
TRbeta (zeige TXNRD2 Antikörper) suppressed Runx2 (zeige RUNX2 Antikörper) transcriptional activities, thus confirming TRbeta (zeige TXNRD2 Antikörper) regulation of Runx2 (zeige RUNX2 Antikörper) at functional thyroid hormone (zeige PTH Antikörper)-response elements. Significantly, these findings indicate that a ratio of the tumor-suppressor TRbeta (zeige TXNRD2 Antikörper) and tumor-promoting Runx2 (zeige RUNX2 Antikörper) may reflect tumor aggression and serve as biomarkers in biopsy tissues. The discovery of this TRbeta (zeige TXNRD2 Antikörper)-Runx2 (zeige RUNX2 Antikörper) signaling supports the emerging role of TRbeta (zeige TXNRD2 Antikörper) as a tumor supp...
results revealed that microRNA 200a inhibits erythroid differentiation by targeting PDCD4 (zeige PDCD4 Antikörper) and THRB
Increased expression of mammary TRbeta1 and DIO2 (zeige DIO2 Antikörper), and decreased RXRalpha (zeige RXRA Antikörper), provide a mechanism to increase thyroid hormone (zeige PTH Antikörper) activity within the mammary gland during lactation.
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.
thyroid hormone receptor beta
, nuclear receptor subfamily 1 group A member 2
, thyroid hormone receptor beta isoform
, thyroid hormone receptor beta 3
, thyroid hormone receptor beta2delta
, thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2)
, TR beta
, thyroid hormone receptor beta 1
, thyroid hormone receptor beta 2
, thyroid hormone receptor beta-1
, oncogene ERBA2
, thyroid hormone nuclear receptor beta variant 1
, thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
, thyroid hormone receptor beta2
, beta-thyroid hormone receptor