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The results of study demonstrate that increased level of expression in the first instance of isoform RARa in combination with hyper-expression of isoform RARbeta but not RARa can have unfavorable significance in case of evaluation of response to medicinal therapy and prognosis of total survival in patients with multiple melanoma.
Hypermethylation of RARB gene is associated with high grade lung cancer.
RAR-beta expression state is one of the independent factors for the prognosis of lung squamous cell carcinoma patients
Although studies reported different rates for RAR beta promoter methylation in prostate can tissues, the total meta-analysis demonstrated that RAR beta promoter methylation may be correlated with prostate cancer carcinogenesis and that the RAR beta gene is particularly susceptible.
Hypermethylation frequency of CpG islands in the promoters of retinoic acid receptor beta gene (RAR-beta) gene was respectively 61 and 33% for diffuse and intestinal type n gastric cancer tissues.
There were significant associations between RARB promoter hypermethylation and Oral Cancer risk.
Results indicate that RARbeta hypermethylation correlates well with an increased risk in non-small cell lung cancer (NSCLC) patients. RARbeta gene inactivation caused by RARbeta methylation contributes the NSCLC tumorigenesis and may serve as a potential risk factor, diagnostic marker and drug target of NSCLC. [review]
retinoic acid receptor beta-retinoic X receptor alpha heterodimer quaternary architecture variable
DBP(n) are non-toxic to the cells and have a weak overall demethylation effect on genomic DNA. DBP(n) demethylate the promoter regions of the tumor suppressor genes PTEN and RARB. DBP(n) promotes expression of the genes RARB, PTEN, CDKN2A, RUNX3, Apaf-1 and APC "silent" in the MCF-7 because of the hypermethylation of their promoter regions
Data shows that miR-106a directly targets RARB 3'-UTR and the miR-106a-RARB complex promotes the viability of thyroid cancer.
Study identified a novel mutation in RARB gene in patients with intellectual disability and progressive motor impairment which confers gain-of-function further promoting the retinoic acid (RA) ligand-induced transcriptional activity by twofold to threefold over the wild-type receptor. These results providing novel insight into the role of RA in neural networks in humans.
mRNAs expression and methylation pattern of RARB, NR4A1 and HSD3B2 genes in human adrenal tissues (HAT) and in pediatric virilizing adrenocortical tumors (VAT) were analyzed.
RARb and FHIT promoter methylation may be associated with the carcinogenesis of cervical cancer. FHIT promoter methylation may play a crucial role in cervical cancer progression. Additional studies with large sample sizes are essential to confirm our findings.
Upregulation of RARB enhances the sensitivity of cholangiocarcinoma cells to chemotherapeutic agents in vitro.
Lack of RARbeta nuclear expression is associated with Non-small cell lung cancer development and associated with a worse prognosis.
methylated promoters of DAPK1 combined with MGMT, MGMT combined with RARB, DAPK1 combined with RARB were positive correlated with cervical disease grade
Overexpression of miR-146a-5p and miR-146b-5p caused a 31% and 33% decrease in endogenous RARB mRNA levels.
shows that RAR-beta methylation detected in lung tissue may be used as a predictive marker for non-small cell lung cancer diagnosis and that APC methylation in tumor sample may be a useful marker
RARbeta2 methylation is significantly increased in breast cancer samples when compared to non-cancerous controls
Whole-exome sequencing in a South American cohort links ALDH1A3, FOXN1 and RARB/retinoic acid regulation pathways to autism spectrum disorders.
This study used CRISPR technology to introduce biallelic frameshift mutations in RAR alpaha, RAR beta, and RAR gamma, thereby abrogating all RAR functions in murine embryonic stem cells. RAR-null cells display no changes in transcripts in response to All-trans-retinoic acid (RA), demonstrating that the RARs are essential for the regulation of all transcripts in murine embryonic stem cells in response to RA.
The RARbeta transcriptional targets were particularly enriched for transcripts affected in Huntington's disease.
These findings suggest that the catalytic and scaffolding activities of TDG are essential for retinoic acid-dependent gene expression and provide important insights into the mechanisms underlying targeting of TET-TDG complexes.
the low expression of RARbeta, may induce the down regulation of p16(INK4a), chronic inflammation and decreased apoptosis and may be involved in vulnerability to HR-HPV and early stage cervical carcinogenesis.
Upregulation of Rarb increases the cytotoxic effect of 5-FU on xenografted cholangiocarcinoma tumors.
Results found that HPV16 E7 increases RARB mRNA and protein expression both in vitro and in the cervix of young K14E7 transgenic mice suggesting that RARB overexpression is part of the early molecular events induced by the E7 oncoprotein.
Chromatin immunoprecipitation assay using RarB as the immunoprecipitation target suggests retinoic acid regulation of Aldh1a3 and Foxn1 in mice.
IL-15 specifically down-regulates RARB expression, and RARB may play a protective role in lung injury caused by smoking or viral infections.
RARB hypermethylation was involved in the areca-associated oral carcinogenesis.
Report liver RAR-beta mediated response to retinoic acid.
Data indicate that all three retinoic acid receptor isoforms RARalha, RARbeta and RARgamma are expressed in naive CD8+ T cells, as well as CD8+ T cells activated for 48 or 72 h.
RARbeta is essential for differentiation of ES cells to pancreatic endocrine cells.
Retinoic acid receptor beta stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice.
Results define PARG as a coactivator regulating chromatin remodeling during retinoic acid receptor-dependent gene expression.
RARbeta expression is involved in splenic cell organization as well as in the maintenance of splenic dendritic cell population.
Retinoic acid (RA), acting through the RA receptor beta (RAR-beta), inhibits myelin-activated Nogo receptor (NgR) signaling through the transcriptional repression of the NgR complex member Lingo-1.
the Rarb region of Mmu14 and Stmn2, but not Cr1 or Clu or Picalm have roles in prion disease
a markedly reduced expression of chemokine (C-X-C motif) ligand 12 (Cxcl12) in the stroma of Rarb-null mice is accompanied by a decrease in the CXCL12/chemokine C-X-C receptor 4 (CXCR4)/ErbB2 signaling axis in the tumors
histone H3 phosphorylation may be a molecular signature of the activated, retinoid-controlled mRARbeta2 gene promoter
Protein Kinase C alpha can influence retinoic acid signaling by altering the stability of Retinoic Acid Receptor beta protein without directly phosphorylating this receptor.
This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. The gene expresses at least two transcript variants\; one additional transcript has been described, but its full length nature has not been determined.
retinoic acid receptor, beta
, retinoic acid receptor beta
, retinoic acid receptor beta-like
, HBV-activated protein
, hepatitis B virus activated protein
, nuclear receptor subfamily 1 group B member 2
, retinoic acid receptor beta 2
, retinoic acid receptor beta 4
, retinoic acid receptor beta 5
, retinoic acid receptor beta variant 1
, retinoic acid receptor beta variant 2
, retinoic acid receptor, beta polypeptide
, RAR beta 2
, retinoic acid receptor beta 1/ beta 3
, retinoic acid receptor beta4'
, retinoic acid receptor-beta