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Although studies reported different rates for RAR beta promoter methylation in prostate can tissues, the total meta-analysis demonstrated that RAR beta promoter methylation may be correlated with prostate cancer carcinogenesis and that the RAR beta gene is particularly susceptible.
Hypermethylation frequency of CpG islands in the promoters of retinoic acid receptor beta gene (RAR-beta) gene was respectively 61 and 33% for diffuse and intestinal type n gastric cancer tissues.
There were significant associations between RARB promoter hypermethylation and Oral Cancer risk.
Results indicate that RARbeta hypermethylation correlates well with an increased risk in non-small cell lung cancer (NSCLC) patients. RARbeta gene inactivation caused by RARbeta methylation contributes the NSCLC tumorigenesis and may serve as a potential risk factor, diagnostic marker and drug target of NSCLC. [review]
retinoic acid receptor beta-retinoic X receptor (zeige xpr1 Proteine) alpha heterodimer quaternary architecture variable
DBP (zeige GC Proteine)(n) are non-toxic to the cells and have a weak overall demethylation effect on genomic DNA. DBP (zeige GC Proteine)(n) demethylate the promoter regions of the tumor suppressor genes PTEN and RARB. DBP (zeige GC Proteine)(n) promotes expression of the genes RARB, PTEN, CDKN2A, RUNX3 (zeige RUNX3 Proteine), Apaf-1 (zeige APAF1 Proteine) and APC (zeige APC Proteine) "silent" in the MCF-7 because of the hypermethylation of their promoter regions
Data shows that miR (zeige MLXIP Proteine)-106a directly targets RARB 3'-UTR and the miR (zeige MLXIP Proteine)-106a-RARB complex promotes the viability of thyroid cancer.
Study identified a novel mutation in RARB gene in patients with intellectual disability and progressive motor impairment which confers gain-of-function further promoting the retinoic acid (RA) ligand-induced transcriptional activity by twofold to threefold over the wild-type receptor. These results providing novel insight into the role of RA in neural networks in humans.
mRNAs expression and methylation pattern of RARB, NR4A1 and HSD3B2 genes in human adrenal tissues (HAT) and in pediatric virilizing adrenocortical tumors (VAT) were analyzed.
RARb and FHIT promoter methylation may be associated with the carcinogenesis of cervical cancer. FHIT promoter methylation may play a crucial role in cervical cancer progression. Additional studies with large sample sizes are essential to confirm our findings.
The RARbeta transcriptional targets were particularly enriched for transcripts affected in Huntington's disease.
These findings suggest that the catalytic and scaffolding activities of TDG (zeige TDG Proteine) are essential for retinoic acid-dependent gene expression and provide important insights into the mechanisms underlying targeting of TET-TDG (zeige TDG Proteine) complexes.
the low expression of RARbeta, may induce the down regulation of p16(INK4a), chronic inflammation and decreased apoptosis and may be involved in vulnerability to HR-HPV and early stage cervical carcinogenesis.
Upregulation of Rarb increases the cytotoxic effect of 5-FU on xenografted cholangiocarcinoma tumors.
Results found that HPV16 E7 increases RARB mRNA and protein expression both in vitro and in the cervix of young K14E7 transgenic mice suggesting that RARB overexpression is part of the early molecular events induced by the E7 oncoprotein.
Chromatin immunoprecipitation assay using RarB as the immunoprecipitation target suggests retinoic acid regulation of Aldh1a3 (zeige ALDH1A3 Proteine) and Foxn1 (zeige FOXN2 Proteine) in mice.
IL-15 (zeige IL15 Proteine) specifically down-regulates RARB expression, and RARB may play a protective role in lung injury caused by smoking or viral infections.
RARB hypermethylation was involved in the areca-associated oral carcinogenesis.
Report liver RAR-beta mediated response to retinoic acid.
Data indicate that all three retinoic acid receptor (zeige RARA Proteine) isoforms RARalha, RARbeta and RARgamma are expressed in naive CD8 (zeige CD8A Proteine)+ T cells, as well as CD8 (zeige CD8A Proteine)+ T cells activated for 48 or 72 h.
This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. The gene expresses at least two transcript variants\; one additional transcript has been described, but its full length nature has not been determined.
retinoic acid receptor, beta
, retinoic acid receptor beta
, retinoic acid receptor beta-like
, HBV-activated protein
, hepatitis B virus activated protein
, nuclear receptor subfamily 1 group B member 2
, retinoic acid receptor beta 2
, retinoic acid receptor beta 4
, retinoic acid receptor beta 5
, retinoic acid receptor beta variant 1
, retinoic acid receptor beta variant 2
, retinoic acid receptor, beta polypeptide
, RAR beta 2
, retinoic acid receptor beta 1/ beta 3
, retinoic acid receptor beta4'
, retinoic acid receptor-beta