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These findings suggested that PPARalpha activation in adipose tissue contributes to the improvement of glucose metabolism disorders via the enhancement of BCAA and FFA metabolism.
Hepatic PARP1 (zeige PARP1 Proteine) activation inhibits FAO pathway upregulation through poly(ADP-ribosyl)ation of PPARalpha, worsening hepatic steatosis and inflammatory responses associated with overnutrition.
TGF-beta (zeige TGFB1 Proteine) and PPARalpha signaling pathways are involved in radiation-induced heart fibrosis, metabolic dysregulation, and impaired heart contractility, a pathophysiological condition that is often observed in patients that received high radiation doses in thorax.
This study identifies an endocrine developmental axis in which fetal GR primes the activity of PPARalpha in anticipation of the sudden shifts in postnatal nutrient source and metabolic demands.
findings identify a new important innate immune function for the PPARalpha signaling pathway in regulating intestinal inflammation, mucosal immunity, and commensal homeostasis
our data indicate that PPAR-alpha mediates antimicrobial responses to mycobacterial infection by inducing TFEB (zeige TFEB Proteine) and lipid catabolism.
adiponectin (zeige ADIPOQ Proteine) inhibited endoplasmic reticulum stress and apoptosis of adipocyte in vivo and in vitro by activating the AMPK (zeige PRKAA1 Proteine)/PPARalpha/ATF2 (zeige ATF2 Proteine) pathway.
It was concluded that decreased cardiac PPARalpha expression is essential for adaptive metabolic remodeling in hypoxia, but is prevented by dietary fat.
these results indicate that PPAR-a accelerates important pathways for the clearance of a-ClFA, and a-ClFA may, in part, accelerate its catabolism by serving as a ligand for PPAR-a
PPARgamma (zeige PPARG Proteine) controls the cancer stem cell niche
Taken together, our data suggest that eupatilin inhibits TNFalpha (zeige TNF Proteine)-induced MMP-2 (zeige MMP2 Proteine)/-9 expression by suppressing NF-kappaB (zeige NFKB1 Proteine) and MAPKAP-1 (zeige MAPKAP1 Proteine) pathways via PPARalpha. Our findings suggest the usefulness of eupatilin for preventing skin aging.
Aleglitazar protects cardiomyocytes against hyperglycaemia-induced apoptosis by combined activation of both peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma (zeige PPARG Proteine).
Study reports a molecular mechanism by which glucocorticoid-induced PPARalpha expression negatively affects the activity of PPARgamma (zeige PPARG Proteine) and downregulates BCO1 (zeige BCMO1 Proteine) gene expression. Results explicate novel aspects of local glucocorticoid:retinoid interactions that may contribute to alveolar tissue remodeling in chronic lung diseases that affect children and, possibly, adults.
Interference with PLIN2 (zeige PLIN2 Proteine) and PPARalpha resulted in major alterations in gene expression, especially affecting lipid, glucose, and purine metabolism.
PPARalpha and FXR (zeige NR1H4 Proteine) function coordinately to integrate liver energy balance.
An association was found with PPARalpha polymorphism and patients with nicotine dependency and schizophrenia.
PPAR agonists have shown to have anti proliferative effect in squamous cell carcinoma of the head and neck.
Results show that PPARalpha is downregulated and SREBP-1c (zeige SREBF1 Proteine) is upregulated in steatosis L-02 cells. These changes increase lipid synthesis and reduce lipid disposal, which ultimately lead to hepatic steatosis.
Perfluoroalkyl acids addition to activating PPARalpha as a primary target, also have the potential to activate CAR, PPARgamma (zeige PPARG Proteine), and ERalpha (zeige ESR1 Proteine) as well as suppress STAT5B (zeige STAT5B Proteine).
The c.*636A>G SNP in the PPARA gene can be considered in Polish Landrace breed as a useful genetic marker for adipose tissue accumulation.
The results indicate that the endometrial expression of PPARalpha genes fluctuates during the estrous cycle and pregnancy.
PPARalpha is likely to play a central role in adaptation to fasting in pig liver
Despite expression of PPAR-alpha in porcine myocardium and effects of fenofibrate on systemic metabolism, treatment with this PPAR-alpha activator does not alter myocardial metabolic or contractile responses to I/R in pigs.
FISH localization of 4 BAC clones harbouring potential candidate genes for fatness traits: DGAT1 (zeige DGAT1 Proteine) (SSC4p15), PPARA (SSC5p15), ADIPOR1 (zeige ADIPOR1 Proteine) (SSC10p13) and CREB (zeige CREB1 Proteine) (SSC15q24)
PPAR profiles in bladder smooth muscle (BSM) may contribute to the susceptibility of BSM to lipotoxicity in the metabolic syndrome.
This study investigated FA composition in yaks and cattle, in order to ascertain whether a correlation between PPARalpha signal pathway genes as candidate genes and meat FA composition in yaks and cattle exists.
OCTN2 (zeige SLC22A5 Proteine) expression and carnitine transport in cattle, as in rodents, are regulated by PPARalpha.
In conclusion, H8H8 haplotype combination of the PPARalpha may be advantageous for heat resistance traits in Chinese Holstein cattle.
Data suggest that PPARalpha (but not PPARgamma (zeige PPARG Proteine)) is involved in vasorelaxation of ophthalmic artery in response to endocannabinoids (i.e., anandamide, palmitoylethanolamide); endothelium removal slightly decreases the response to endocannabinoids.
Data from gene profiling experiments in bovine cell line support hypothesis that saturated long-chain fatty acids modulate ruminant lipid metabolism and expression of inflammation mediators with major effects induced via activation of PPARalpha.
Dietary trans fatty acids may affect liver lipid metabolism in post-partum dairy cows through alterations in PPARalpha gene expression.
Oxidized fataprevent an alcohol-induced triacylglycerol accumulation in rats possibly by upregulation of hepatic PPARalpha-responsive genes, whwereas conjugated linoleic acid does not.
The results are consistent with the hypothesis that arachidonic acid acts via PPARalpha to increase PTGS2 (zeige PTGS2 Proteine) levels in bovine endometrial stromal cells.
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers\; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.
peroxisome proliferator-activated receptor alpha
, ppar alpha
, peroxisome proliferator activated receptor alpha
, peroxisome proliferator-activated receptor-alpha
, nuclear receptor subfamily 1 group C member 1
, peroxisome proliferative activated receptor, alpha
, peroxisome proliferator-activated nuclear receptor alpha variant 3
, PPAR alpha
, xPPAR alpha