Protein Überblick

Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type- specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock\; is required early in the development of the locus coeruleus (LC).

Alternative names and synonyms associated with Nuclear Receptor Subfamily 2, Group F, Member 6 (NR2F6)

• nuclear receptor subfamily 2 group F member 6 (NR2F6) Antikörper
• nuclear receptor subfamily 2, group F, member 6 (Nr2f6) Antikörper
• nuclear receptor subfamily 2, group F, member 6a (nr2f6a) Antikörper
• nuclear receptor subfamily 2 group F member 6 L homeolog (nr2f6.L) Antikörper
• nuclear receptor subfamily 2 group F member 6 (nr2f6) Antikörper
• Alle Gen-Bezeichnungen
• nuclear receptor subfamily 2, group F, member 6 (NR2F6) Antikörper
• nuclear receptor subfamily 2 group F member 6 (Nr2f6) Antikörper
• nuclear receptor subfamily 2, group F, member 6b (nr2f6b) Antikörper

• AV090102 Antikörper
• COUP(II) Antikörper
• COUP-TF3 Antikörper
• couptf2 Antikörper
• ear-2 Antikörper
• Alle Synonyme
• ear2 Antikörper
• erbal2 Antikörper
• fc94g11 Antikörper
• NR2F6 Antikörper
• nr2f6l Antikörper
• wu:fc72d04 Antikörper
• wu:fc94g11 Antikörper
• zgc:77259 Antikörper
• zgc:77260 Antikörper

Bezeichner auf Proteinebene für NR2F6

ERBA-related gene-2 , V-erbA-related protein 2 , nuclear receptor V-erbA-related , nuclear receptor subfamily 2 group F member 6 , v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 2 , COUP transcription factor 3 , EAR-2 , avian erythroblastic leukemia viral (v-erb-a) oncogene homolog-like 2 , COUPg , V-erbA-related protein EAR-2 , orphan nuclear receptor EAR-2 , ovalbumin upstream promoter gamma nuclear receptor rCOUPg , EAR2-A , chicken ovalbumin upstream promoter transcription factor 2 , nuclear receptor subfamily 2, group F, member 6 , EAR2-B , fc72d04 , nr2f6