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Mouse (Murine) NR1H3 ELISA Kit für Sandwich ELISA - ABIN425265
Schmitt, Kong, Stieger, Tschopp, Schultze, Rau, Weber, Müllhaupt, Guo, Geier: Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal. in Liver international : official journal of the International Association for the Study of the Liver 2015
Liver x receptor modulation of gene expression leads to proluteolytic effects in primate luteal cells. LXR activation causes increased cholesterol efflux and decreased extracellular cholesterol uptake.
Data identify LXR as an important factor in early-pregnancy lipogenesis that is also necessary to protect against abnormalities in fetoplacental lipid homeostasis.
data suggest that ASXL3 is another corepressor of LXRalpha, promoting to the regulation of lipid homeostasis
results indicated that LXRalpha plays a specific and important role in activation of TH by regulating D1, and that LXRalpha binds to and regulates the hDIO1 promoter, competing with TRbeta (zeige TXNRD2 ELISA Kits) on specific sequences within the promoter.
GW3965 significantly increases the expression of liver X nuclear receptor beta (zeige NR1H2 ELISA Kits) (LXRbeta (zeige NR1H2 ELISA Kits)) mRNA, while the liver X nuclear receptor alpha (LXRalpha( mRNA expression did not change a lot, and sensitizes gefitinib by inhibiting NF-kappa B (NF-kappaB (zeige NFKB1 ELISA Kits)) activation.
Transactivation assays showed that MCFA activated LXRa, whereas long-chain FA caused no effect. Our results suggest that LXRa functions as a receptor for saturated FA or acyl-CoA of C10 and C12 in length.
We demonstrated that LXR stimulation decreases mRNA and protein expression of FLOT2 (zeige FLOT2 ELISA Kits) and DHHC5 (zeige ZDHHC5 ELISA Kits) in MCF-7 cells. LXR stimulation also reduces Akt (zeige AKT1 ELISA Kits) phosphorylation and its localization at the plasma membrane
The effects of LXR agonist on interleukin-8 (IL-8 (zeige IL8 ELISA Kits)) secretion and nuclear factor-kappa B (NF-kappaB (zeige NFKB1 ELISA Kits)) activation in human umbilical vein endothelial cells (HUVECs), is reported.
Collectively, these findings demonstrate that LXRalpha activation induces 17beta-HSD13 expression in a SREBP-1c (zeige SREBF1 ELISA Kits)-dependent manner.
mutant NR1H3 (LXRA) alters gene expression profiles, suggesting a disruption in transcriptional regulation as one of the mechanisms underlying Multiple Sclerosis pathogenesis.
Data show that the synthetic liver X receptors (LXRs) agonist T0901317 promoted cytokines IL-1beta (zeige IL1B ELISA Kits), IL-6 (zeige IL6 ELISA Kits) and TNFalpha (zeige TNF ELISA Kits) mRNA degradation, destabilized TNFalpha (zeige TNF ELISA Kits) mRNA through its 3'-untranslated region, and increased the expression of tristetraprolin (TTP (zeige ZFP36 ELISA Kits)).
Wild-type mice and transgenic mice deficient for both alpha and beta Liver X Receptor isoforms were fed a control or an oleate enriched diet; results suggests that dietary oleic acid reduces cholesterolemia while promoting LXR-dependent hepatic lipogenesis without detrimental effects to the liver.
treatment of APP/E4/Abca1+/- mice with liver X receptor (LXR) agonist T0 ameliorates APOE4-induced Alzheimer's disease (AD)-like pathology and therefore targeting the LXR-ABCA1-APOE regulatory axis could be effective as a potential therapeutic approach in AD patients, carriers of APOEepsilon4
Our data indicate that a combination of vildagliptin and pravastatin significantly induces the expression of LXR-ABCA1 (zeige ABCA1 ELISA Kits)/ABCG1 (zeige ABCG1 ELISA Kits) cascade and improves cholesterol efflux (P > 0.05) in adipocytes. Our data may explain, at least in part, the improvement in HDL (zeige HSD11B1 ELISA Kits)-C levels observed in patients receiving both medications
We describe a molecular pathway comprising miR-155 and its epigenetic LXRalpha target that when deregulated enables pathogenic pulmonary fibrosis. Manipulation of the miR-155/LXR pathway may have therapeutic potential for idiopathic pulmonary fibrosis.
27OH is not an important regulator of Srebp- or LXR regulated genes under basal conditions in mouse liver
within the CNS, each LXR isoform differentially influences myelin gene mRNA levels in a region- and age-dependant manner, participating in the fine regulation of myelin gene expression
EEPD1 is a novel LXR-regulated gene in macrophages and that it promotes cellular cholesterol efflux by controlling cellular levels and activity of ABCA1 (zeige ABCA1 ELISA Kits).
luteolin can abolish lipid accumulation induced by LXR-SREBP-1c (zeige SREBF1 ELISA Kits) activation both in vivo and in vitro
induction of ABCG1 expression by MEK1/2 inhibitors was associated with activation of SIRT1, a positive regulator of LXR activity, and inactivation of SULT2B1 and RIP140, two negative regulators of LXR activity
geranylgeranyl pyrophosphate may act as an endogenous regulator of adipocyte differentiation and maturation through a mechanism partially dependent on the LXR pathway.
The effects of genetic polymorphisms of liver X receptor, alpha (LXR), stearoyl-CoA desaturase (SCD (zeige SCD ELISA Kits)), Fatty acid synthase (FASN (zeige FASN ELISA Kits)), and Fatty acid binding protein 4 (FABP4) were investigated on fatty acid composition in fat tissue of steers.
LXRalpha V133I polymorphism had a significant effect on linoleic acid composition in intramuscular fat.
Intestinal nr1h3 activation delays transport of absorbed neutral lipids, with accumulation of neutral lipids in enterocyte cytoplasmic droplets.
Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis
Results describe transcriptional activity and developmental expression of liver X receptor (lxr) in zebrafish.
Allele A of the exon5-A201C in NR1H3 promotes a reduction in backfat thicknes.NR1H3 plays role in lipid deposition.
discovery and examination of two polymorphisms in LXRA (LXRA Bsl in exon 2, and LXRA HpyCH4 III in intron 8) and one polymorphism in LXRB (LXRB (zeige NR1H2 ELISA Kits) Aci I in exon 5) for genetic linkage and association analyses in fat content or leanness in pigs [LXRA & LRRB]
The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
nuclear receptor subfamily 1, group H, member 3
, oxysterols receptor LXR-alpha-like
, liver X nuclear receptor alpha variant 1
, oxysterols receptor LXR-alpha
, LXR alpha
, liver X receptor alpha
, ubiquitously-expressed nuclear receptor 1
, nuclear orphan receptor LXR-alpha
, nuclear receptor subfamily 1 group H member 3
, liver X receptor
, nuclear oxysterol receptor LxR-alpha