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Human Monoclonal ESR2 Primary Antibody für ChIP, DB - ABIN152350
Kuiper, Carlsson, Grandien, Enmark, Haeggblad, Nilsson, Gustafsson: Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. in Endocrinology 1997
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Human Monoclonal ESR2 Primary Antibody für ChIP, ICC - ABIN152348
Bianco, Perry, Smith, Templeton, Montano: Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage. in Molecular endocrinology (Baltimore, Md.) 2003
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Human Monoclonal ESR2 Primary Antibody für ChIP, IP - ABIN445498
Burakov, Crofts, Chang, Freedman: Reciprocal recruitment of DRIP/mediator and p160 coactivator complexes in vivo by estrogen receptor. in The Journal of biological chemistry 2002
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Human Monoclonal ESR2 Primary Antibody für IHC, WB - ABIN152349
Fuchsjäger-Mayrl, Nepp, Schneeberger, Sator, Dietrich, Wedrich, Huber, Tschugguel: Identification of estrogen and progesterone receptor mRNA expression in the conjunctiva of premenopausal women. in Investigative ophthalmology & visual science 2002
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Cow (Bovine) Polyclonal ESR2 Primary Antibody für GS, ICC - ABIN267203
Muhammad, Maznah, Mahmud, Saeed, Imam, Ishaka: Estrogen receptor modulatory effects of germinated brown rice bioactives in the uterus of rats through the regulation of estrogen-induced genes. in Drug design, development and therapy 2013
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Human Monoclonal ESR2 Primary Antibody für IHC (p) - ABIN2473529
Howard: Studies on urinary stone formation: a saga of clinical investigation. in The Johns Hopkins medical journal 1977
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Human Monoclonal ESR2 Primary Antibody für IHC (p) - ABIN2473530
Saunders, Millar, Macpherson, Irvine, Groome, Evans, Sharpe, Scobie: ERbeta1 and the ERbeta2 splice variant (ERbetacx/beta2) are expressed in distinct cell populations in the adult human testis. in The Journal of clinical endocrinology and metabolism 2002
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Human Polyclonal ESR2 Primary Antibody für FACS, IF (p) - ABIN725210
Fang, Wu, Huang: Raloxifene upregulated mesangial cell MMP-2 activity via ER-? through transcriptional regulation. in Cell biochemistry and biophysics 2013
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Human Monoclonal ESR2 Primary Antibody für IP, IHC - ABIN2668755
Dan, Cheung, Scriven, Moore: Epitope-dependent localization of estrogen receptor-alpha, but not -beta, in en face arterial endothelium. in American journal of physiology. Heart and circulatory physiology 2003
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Human Polyclonal ESR2 Primary Antibody für WB - ABIN1881321
Fang, Lu, Wang, Wu, Li, Zhang, Pan, Wan: Prognostic impact of ERβ and MMP7 expression on overall survival in colon cancer. in Tumour biology 2010
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Papillary thyroid carcinoma was characterized by high expression of ESR2 and AR, which was associated with expression and content of nuclear factors Brn-3A and TRIM16.
Modulation of mitochondrial ERbeta expression by Grp75 inhibits triple-negative breast cancer tumor progression by activating mitochondrial function.
results from the above studies demonstrated that ERbeta can promote NSCLC VM formation and cell invasion via altering the ERbeta/MALAT1/miR145-5p/NEDD9 signaling. Targeting this newly identified signaling pathway with small molecules may help the development of novel therapies to better suppress the NSCLC metastasis.
Nuclear expression of ER - beta was more frequently observed in early stage Non-small Cell Lung Cancer in never-smokers.
The analysis revealed that severities in the impairment of social interaction and emotional regulation were linked to SNPs in ESR2 rs1152582.The effect of genotype was not observed for the other aspects of Autism spectrum disorders symptoms in Japanese individuals.
Analysis of docked conformations in terms of binding energy disclosed estrogen receptor-beta (ERb) as more promising than estrogen receptor-alpha (ERa). Evaluation of MD trajectories of ZER bound to both ERa and ERb showed appreciable stability with minimum Calpha-atom root mean square deviation shifts
A suppressive effect of ERbeta agonists on the growth of ERb-expressing chronic lymphocytic leukemia (CLL) cells was found, indicating that ERb may be considered as a potential therapeutic target in CLL.
Results provide evidence for the involvement of ERb1 in the mechanism that regulates DNA damage response in non-small cell lung cancer cells.
Activation of estrogen receptor beta (ERbeta) regulates the expression of N-cadherin, E-cadherin and beta-catenin in androgen-independent prostate cancer cells.
An association was found between the rs1256032 polymorphism of estrogen receptor beta gene and reduced risk in a Mexican population of developing type 2 diabetes.
We identified a homozygous ESR2 variant, c.541_543del p.(Asn181del) in the highly conserved DNA-binding domain of ER-beta in an individual with syndromic 46,XY DSD. Two additional heterozygous missense variants, c.251G>T p.(Gly84Val) and c.1277T>G p.(Leu426Arg), located in the N-terminus and the ligand-binding domain of ER-beta, were found in unrelated, nonsyndromic 46,XY DSD cases.
No association between polymorphisms in genes encoding estrogen receptors (ESR1 and ESR2) and excreted BPA levels was found in orthodontic patients after bracket bonding.
Reduced expression of ERbeta1 in female ERalpha-negative papillary thyroid carcinoma patients is associated with greater progression of the disease.
therapeutic activation of ERbeta elicits potent anticancer effects in Triple-negative breast cancer through the induction of a family of secreted proteins known as the cystatins, which function to inhibit canonical TGFbeta signaling and suppress metastatic phenotypes both in vitro and in vivo.
ESR2 polymorphisms demonstrate minimal influence on Bone mineral density changes in women.
In summary, an association between the presence of the particular genotypes at the three ESR1 polymorphisms (rs2234693, rs6902771, rs7774230) and one ESR2 polymorphism (rs3020449), and the presence of metabolic syndrome in postmenopausal women was found.
Low ESR2 expression is associated with Tumor Progression in Colorectal Cancer with Familial Adenomatous Polyposis and Sporadic Polyps.
The possible role of ESR2 G1730A variant as the risk factor of MI in a young age.
TCF21 modulates Steroidogenic factor-1 and estrogen receptor beta expression through the recruitment of USF2 in endometriotic stromal cells.
High phosphorylated ESR2 expression is associated with pancreatic ductal adenocarcinoma.
Comprehensive genetic analysis for differential functions of esr1, esr2a, and esr2b in fish reproduction.
although esr2b mutant fish showed unaltered antibacterial responses, they were unable to mount an effective antiviral response upon viral challenge.
Data suggest that endocrine disruptor, 17alpha-ethinylestradiol, disrupts primordial germ cell migration and distribution in embryonic zebrafish; this effect appears to be mediated through estrogen receptor Esr2a (not Esr1 or Esr2b).
This study revealed similar patterns of transcript abundance across reproductive morphs for ERbeta1, ERbeta2, ERalpha, and aromatase in the forebrain and saccule.
It was concluded that morpholino (MO) oligonucleotid technology in zebrafish embryos is an good approach for investigating the interplay of estrogen receptor subtypes in a true physiological context.
Report stable reporter gene assays based on stable expression of subtypes of zebrafish ER (zfERalpha, zfERbeta1, and zfERbeta2) coupled to estrogen response element-driven luciferase in a zebrafish liver cell line.
Involvement of maternal esr2a mRNA, presumably transactivated by maternal 17beta-estradiol stored in the oocyte from enveloping granulosa cells, in the epigenetic programming of zebrafish development.
during embryogenesis two of the three 17beta-estradiol receptor genes, esr1 and esr2b are expressed, and in presence of ligand the mRNA levels of these two genes increase
Data show that temperature and photoperiod significantly influence the transcription of the estrogen-responsive genes, Vtg1, Vtg2, ER alpha and ER beta after a 21-day exposure to endocrine-disrupting chemicals.
Cloning of the cDNAs corresponding to three oestrogen receptors (esr1, ERalpha; esr2b, ERbeta1; and esr2a, ERbeta2 ).
Data show that the hepatic expression of estrogen receptor alpha, beta1 and beta2 genes responds differently to estradiol.
genistein binds and activates the three zebrafish estrogen receptors ERalpha, ERbeta-A and ERbeta-B and induces apoptosis in an ER-independent manner
Induction of apolipoprotein Eb (apoeb) and up-regulation of estrogen receptor 2a (esr2a) transcripts were observed in the epidermis at initiator sites of zebrafish ectodermal/dermal appendage morphogenesis.
We conclude that signaling via ERbeta(2) is essential for hair cell development and may involve an interaction with the Notch signaling pathway during cell fate decision in the neuromast maturation process.
This study examined the calibration of follicular development in chickens and cattle according to gene expression patterns. Unlike mammals, ESR2 was implicated as one of transcription factors regulating CYP19A1 expression in chicken follicles.
The mRNA expression of ER-alpha and ER-beta in the hypothalamus of developing male and female bovines, is reported.
ER-alpha is detected predominantly in the soma whereas ER-beta is only present in the nucleus of a few cells in the frontal cortex.
fetal ovary of cattle has the steroidogenic enzyme aromatase to convert androgens to estradiol-17beta, and estrogen receptors alpha and beta to facilitate an estrogen response within the fetal ovary
there are different levels of ERalpha, ERbeta and PR in bovine oviducts at different cycle stages in vivo
ER may play a role in the rapid effects of resveratrol in EC and some of the atheroprotective effects of resveratrol may be mediated through rapid activation of ER signaling in EC
The expression of estrogen and progesterone receptors in ovarian follicular structures from cows with cystic ovarian disease (COD) and a comparison of these with normal ovarian structures are reported.
These data indicate that PGF2alpha, TNFalpha and IFNgamma regulate ERalpha and ERbeta mRNA expressions in bovine luteal cells.
Roles of IGF-I and the estrogen, androgen and IGF-I receptors in estradiol-17beta- and trenbolone acetate-stimulated proliferation of cultured bovine satellite cells.
an 17b-estradiol-induced increase in the proliferation of rhesus retinal capillary endothelial cells may be mediated by the action of ERb.
Estradiol can weakly modulate the motility and this effect is strictly associated with GPER and not with ESR1 and ESR2. The subcellular localization of GPER in the neck on stallion sperm is coherent with this effect.
The presence of a single isoform of ESR1 (66kDa) and ESR2 (61kDa) was found by Western-blot analysis in samples from seven stallions and the expression of the seven transmembrane estradiol binding receptor GPER in colt testis.
expression of estrogen receptor alpha and beta and progesterone receptor in equine microplacentomes gives evidence for a role of placental steroids as regulators of placental function
There were no statistical differences between the BB genotype and the AB genotype of ESR2 locus in regard to the examined traits. However, a noticeable superiority (P < 0.01) of the BB genotype compared to the homozygous AA genotype, adding almost 2 piglets/litter in TNB and NBA trait, was found.
steroid hormones, AhR and estrogen receptor beta are affected by TCDD and genistein in granulosa cells of medium porcine follicles
Results suggest that expression levels of protease activated receptors 1 and 2 (PAR-1 and PAR-2) associate with breast cancer outcome in an estrogen receptor (ER)-dependent manner.
results might shed new light on the roles of estrogen receptor 2(ESR2) in spermatogenesis as candidate for boar fertility
study is the first one to demonstrate the presence of estrogen receptors alpha and beta in the porcine uterus not only at the beginning but also at mid- and late pregnancy
Downregulation of the ERs, particularly ERalpha in the myometrium and endometrial stroma, might be a relevant mechanism in the antagonism of estrogenic effects by dihydrotestosterone in the pig uterus.
the results of the present study suggest the involvement of estrogen receptor beta in estrogen modulation of pig epididymal function
findings suggest that testicular oestrogen receptors alpha and beta may be important factors contributing to onset and maintenance of spermatogenesis in the boar
ERbeta mRNA was found only in Sertoli cells in the testis.
positive staining for ERalpha in the nuclei of skeletal muscle cells, while the ERbeta stain showed positive signals in nuclei and cytoplasm of skeletal myofibers and myoblasts derived from satellite cells
ESR2 gene polymorphisms are associated with litter size.
The objective of this study was to search for polymorphisms in the coding region of the estrogen receptors 1 and 2 (ESR1 and ESR2) and to analyze the effects of these variants and the well known intronic ESR1 PvuII polymorphism on litter size.
These data demonstrate novel and differential mechanisms by which ERalpha and ERbeta activation control coronary artery vasoreactivity in males and females and regulate vascular NO and O(2)(-) formation.
Pig ejaculated spermatozoa express estrogen receptor.
The expression of mRNAs for ERalpha, ERbeta and PR in the sow uterus differed between endometrium and myometrium as well as with stages of the estrous cycle and early pregnancy.
In conclusion, sex chromosome complement governs the hormonal regulation of aromatase expression through activation of ERbeta in developing mouse brain.
ERalpha-signaling may be crucial for vibration-induced effects on fracture healing, whereas ERbeta-signaling may play a minor role
Study traced individual dendritic spines on layer V pyramidal neurons of the primary sensory cortex in adult female mice under 17beta-estradiol (E2) intervention using two-photon in vivo imaging microscopy; found increase of the spine density upon E2 treatment in the intact cortex due to the promotion of spine formation and the stability of newly formed spines.
Estrogen receptor beta modulates mitochondrial permeability transition by regulating CypD interaction with OSCP.
These data demonstrate chemoarchitectural differences in ERbeta neurons of the mouse paraventricular nucleus.
Study found that estrogen receptor beta (ERbeta) was expressed in the motoneurons of lumbar ventral horn. ERalpha and ERbeta were mainly localized in the nuclei of motoneurons with less immunoreactivity in the cytoplasm.
Data suggest that expression of Usp19 in skeletal muscle can be regulated by dietary factors; here, supplementation with phytoestrogen daidzein down-regulates Usp19 expression via Esrb signaling and increases skeletal muscle mass. (Usp19 = ubiquitin-specific peptidase 19; Esrb = estrogen receptor beta)
The role of ERbeta in opposing AR signaling, proliferation, and inflammation suggests that ERbeta-selective agonists may be used to prevent progression of prostate cancer, prevent fibrosis and development of benign prostatic hyperplasia, and treat prostatitis.
Data suggest that one alternative splicing variant of Esr2 is "super-activated" by xenoestrogens; here, samples isolated from soil around a landfill site in the United Kingdom appear to contain xenoestrogens that induce cholangitis.
The administration of ICI182,780, which is an agonist of G-protein coupled estrogen receptor (GPER) and an antagonist of ERa and ERb, did not result in protection; however, ICI182,780 significantly blocked EDC-mediated cardioprotection, indicating participation of ERalpha and/or ERbeta
ERbeta might be the target protein of arctigenin responsible for inhibition of mTORC1 activation and resultant prevention of Th17 cell differentiation and colitis development.
Taken together, the above results clearly demonstrated an mTORC2-dependent regulation of actin polymerization that contributed to the effects of ERalpha and ERbeta on spatial learning, which may provide a novel target for the prevention and treatment of E2-related dementia in the aged population
Results provide evidence that ERbeta prevents cardiac fibroblasts to undergo fibrosis development.
Increased DNA methylation accompanied this pattern, particularly at CpG dinucleotides located within binding or flanking regions for the transcriptional regulator CCCTC-binding factor of ESR1 and ESR2, consistent with sustained transcriptional activation of ERa and ERb
These data highlight a new role for ER-beta in adipose biology and its potential to be a safer alternative peripheral therapeutic target for obesity.
Results indicated that puerarin is neuroprotective against Abeta1-42 toxicity via the activation of estrogen receptors, and ERbeta plays a key role in the process. Rindings provide a potential strategy for the prevention of neurodegeneration and the treatment of Alzheimer's disease.
Phosphorylation of myosin regulatory light chain triggered by E2 was found to be mediated by estrogen receptor-beta and the G protein-coupled estrogen receptor.
The present results showed that ER knockout alpha and beta male mice had lower striatal mGlu5 receptor binding and protein measured by Western blot.
Kiss1 in the medial amygdala is regulated primarily by estrogen receptor alpha, and not estrogen receptor beta.
ER-alpha plays a more critical role in promoting adipose-derived stem cells proliferation and migration while ER-beta is more potent in suppressing adipose-derived stem cells brown adipose tissue differentiation mediated by decreased UCP-1, PGC-1alpha and PPAR-x03B3; expression.
ERbeta1 and -beta2 mRNA-expressing neurons (ERbeta1 and ERbeta2 neurons, respectively) were distributed in some structures of the telencephalon, diencephalon, and hindbrain
cloned three ER subtypes (ERalpha, ERbeta1, and ERbeta2), and examined their developmental expression in the gonads of females and males during embryonic and larval development
The expression of androgen receptors, estrogen receptor beta, and bone morphogenetic protein 2b in male and female Japanese and Thai medaka are reported.
The main functional structure domains of the ESR2 in a Jining Gray female goat have been described.
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.
estrogen nuclear receptor beta variant a
, estrogen nuclear receptor beta variant b
, estrogen receptor beta
, estrogen receptor beta 4
, nuclear receptor subfamily 3 group A member 2
, estrogen receptor beta1
, estrogen receptor beta 2
, estrogen receptor 2 (ER beta)
, estradiol receptor beta
, steroid receptor
, ER beta
, oestrogen receptor beta
, estrogen receptor beta2
, estrogen receptor 2 beta
, Nuclear receptor subfamily 3 group A member 2
, estrogen receptor beta-like
, estrogen receptor 2 (beta)