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The specific autophagosomal localization of both WIPI1 and WIPI2 (refered to as WIPI puncta) has been employed to assess autophagy using fluorescence microscopy methods, such as confocal and live-cell video microscopy
Data suggest WIPI1/WIPI2 co-localize with microtubule-associated light chain 3 and autophagy related proteins 2/14L, participate in biogenesis of phagosomes, autophagy, and mobilization of lipids to/from intracellular droplets. [review-like article]
WIPI-1 and WIPI-2 are functionally required in mediating the PI3P signal at the onset of autophagy in NB4 cells.
the detection of WIPI1 mRNA is likely to be a convenient method of monitoring autophagosome formation in a wide range of cell types
Freeze-fracture replica immunolabelling reveals WD-repeat protein interacting with phosphoinositides 1 and 2 (WIPI-1 and WIPI-2) as membrane components of autophagosomes and the plasma membrane (PM).
Studies define a distinct role for WIPI1 and TORC1 signaling in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy.
share an evolutionary conserved function in autophagy and that autophagic capacity may be compromised in human cancers
Quantification of WIPI-1 puncta should be suitable to assay mammalian autophagy
WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004
WD repeat domain phosphoinositide-interacting protein 1
, WD40 repeat protein Interacting with phosphoInositides of 49kDa
, WD40 repeat protein interacting with phosphoinositides of 49 kDa
, WIPI 49 kDa
, WIPI-1 alpha
, atg18 protein homolog
, WD repeat domain, phosphoinositide interacting 1
, WD repeat domain phosphoinositide-interacting protein 1-like
, WD repeat domain, phosphoinositide-interacting 1