Presenilin 2 Proteine (PSEN2)

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.

• presenilin 2 (PSEN2)
• presenilin 2 (psen2)
• presenilin 2 (Psen2)
• presenilin 2 S homeolog (psen2.S)
• presenilin 2 (Alzheimer disease 4) (PSEN2)

• AD3L Protein
• AD4 Protein
• Ad4h Protein
• ALG-3 Protein
• Alg3 Protein
• Alle Synonyme
• CMD1V Protein
• pre2 Protein
• PS-2 Protein
• PS2 Protein
• PSEN2 Protein
• PSNL2 Protein
• STM2 Protein
• zf-PS2 Protein

presenilin 2 (Alzheimer disease 4) , presenilin-2 , PS-2 , AD3LP , AD5 , E5-1 , STM-2 , PS-beta , presenilin beta , presenilin-beta