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Mouse (Murine) Notch1 Protein expressed in CHO Cells - ABIN1344230
Fiorini, Merck, Wilson, Ferrero, Jiang, Koch, Auderset, Laurenti, Tacchini-Cottier, Pierres, Radtke, Luther, Macdonald: Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies. in Journal of immunology (Baltimore, Md. : 1950) 2009
In this study, we were aimed to investigate whether the cross talk between pin1 (zeige PIN1 Proteine) and Notch1 has a role in this event. Our results indicated that the expression level of Pin1 (zeige PIN1 Proteine) in resistant SKBR3 cells increased by about twofold relative to sensitive SKBR3 cells. Besides, Pin1 (zeige PIN1 Proteine) inhibition via juglone reduced the extent of proliferation, colony formation and migration capacity of resistant SKBR3 cells
Results suggest that Notch1 pathway and miR (zeige MLXIP Proteine)-151-5p interplay with p53 (zeige TP53 Proteine) in a reciprocal regulation loop in controlling gastric carcinogenesis.
A three-molecule score based on the expression of Notch pathway molecules: Jagged1 (zeige JAG1 Proteine), intracellular Notch1 (ICN1) and Hes1 (JIH score) to assess prognostic value in non-metastasis clear cell renal cell carcinoma (zeige MOK Proteine) (ccRCC).
Results show that Notch1 mediates CCR7 (zeige CCR7 Proteine)-promoted stemness in mammary cancer cells.
The knockdown of Notch1 leads to the inhibition of cell invasion and metastasis and reactivation of PTEN protein which leads to decreased expression of PhosphoAkt and PhosphoFAK.
The results of this study suggest that Notch1 expression plays different roles in tumor progression in ATC (zeige SRPK1 Proteine) and PTC (zeige F9 Proteine) cells. We also found that Notch1 expression was significantly related to the highly invasive or proliferative activity of ATC (zeige SRPK1 Proteine) cells.
hypoxia-NOTCH1-SOX2 (zeige SOX2 Proteine) signaling axis is important for activation of ovarian cancer stem cells.
Our study provides functional evidence that the Notch1 signaling axis synergizes with alternative pathways in promoting metastatic CRPC and may represent a new therapeutic target for advanced prostate cancer.
TLR3 (zeige TLR3 Proteine)-activated Notch-1 signaling regulated the immune suppression of human umbilical cord-derived mesenchymal stem cells
Notch1 regulates the aggressive phenotypes of DTC, which could be mediated by SERPINE1 (zeige SERPINE1 Proteine) inhibition.
Taken together, these findings indicate that GAS5 may promote the progression of ischemic stroke through acting as a ceRNA for miR (zeige MLXIP Proteine)-137 to mediate the Notch1 signaling pathway, which contributes to an extensive understanding of ischemic stroke and may provide novel therapeutic options for this disease.
Data show that Wnt (zeige WNT2 Proteine) beta-Catenin (zeige CTNNB1 Proteine) signaling pathway activation followed by Notch inhibition strongly promotes the mitotic regeneration of new hair cell (HC) in both normal and neomycin-damaged cochleae.
Data suggest that Numb (zeige NUMB Proteine) acts as a Notch antagonist by controlling intracellular destination and stability of the Notch ligand (zeige JAG2 Proteine) Delta-like (zeige DLK1 Proteine) 4 (DLL4 (zeige DLL4 Proteine)) through a post-endocytic sorting process; Numb (zeige NUMB Proteine) negatively controls DLL4 (zeige DLL4 Proteine) plasma membrane recycling through well-documented recycling regulator protein AP1 (zeige JUN Proteine).
Data show that NOTCH1 is a target of ADAMTS1 (zeige ADAMTS1 Proteine) metalloproteinase activity, which reduces Notch signaling, leading to increased satellite cell activation.
Notch1 signaling is activated in brain endothelial cells cocultured with astrocytes, and astrocytic Jagged1 expression is required for angiogenic enhancement.
Sirt6 (zeige SIRT6 Proteine) inhibits Notch1 and Notch4 (zeige NOTCH4 Proteine) transcription by deacetylating histone H3K9.
Notch signaling is required for the formation of all nephron segments and it primes nephron progenitors for differentiation rather than directing their cell fates into a specific nephron segment.
Hypothyroidism induces a significant reduction of proteases Isp1 and Isp2 gene expressions and Notch signaling.
Results indicate a key role of the Notch1 receptor in myeloid cells for the initiation and progression of experimental autoimmune encephalomyelitis (EAE).
PrP(C (zeige PRNP Proteine)) controls the expression of the epidermal growth factor receptor (EGFR (zeige EGFR Proteine)) downstream from Notch.
Notch initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3
Notch signaling promotes floor plate and hypochord fates over notochord, but has variable effects on Shh (zeige SHH Proteine) expression in the midline.
Transgenic tadpoles were prepared with an elastase promoter driving either the stromelysin-3 (zeige MMP11 Proteine) gene or the constitutively active form of Notch (IC).
ZFP423 coordinates Notch1 and bone morphogenetic protein signaling, selectively up-regulating Hes5 (zeige HES5 Proteine) gene expression.
results suggest that a cell-to-cell interaction via the Notch/Su(H (zeige RBPJ Proteine)) pathway has a significant role in the PGC (zeige PGC Proteine) migration by regulating cell motility
the process of delimiting the three germ layers requires Notch signaling.
BCL6 (zeige BCL6 Proteine) inhibits transcription by competing for the Notch1 intracellular domain, preventing the coactivator Mastermind-like1 (MAM1 (zeige MAML1 Proteine)) from binding.
the combination of XSICD-mediated intracellular signaling and the extracellular domain of Notch ligands-mediated activation of Notch receptor is involved in the primary neurogenesis
Notch signaling is activated when activin-like signaling induces various tissues from homogenous undifferentiated cells.
Notch controls smad2 (zeige SMAD2 Proteine) nuclear localization and the competence of ectodermal cells for activin A (zeige INHBA Proteine) in Xenopus embryos
the NOTCH1 polymorphism g.A48250G was significantly associated with body height, body weight, and height at hip cross, and that g.A49239C only showed significant associations with body height
bovine herpesvirus 1 ORF2 protein reduced the trans-activation potential of Notch1 and Notch3 (zeige NOTCH3 Proteine), suggesting that ORF2 interfered with the trans-activation potential of Notch.
Cellular size or Notch1 expression is not per se a specific marker for mesenchymal progenitor cells in adult articular cartilage.
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.
, Notch homolog 1, translocation-associated (Drosophila)
, Notch homolog 1, translocation-associated
, neurogenic locus notch homolog protein 1
, translocation-associated notch protein TAN-1
, Motch A
, Notch gene homolog 1
, major type A protein
, transmembrane receptor Notch1
, Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila)
, neurogenic locus notch protein homolog