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BCL6 (zeige BCL6 Proteine) inhibits transcription by competing for the Notch1 (zeige NOTCH1 Proteine) intracellular domain, preventing the coactivator Mastermind-like1 (MAM1) from binding.
XMam1 has the ability to induce the cell fate into the neurogenic lineage in a Notch (zeige NOTCH1 Proteine)-independent manner
The present study shows a new role for Maml1 as a component of Shh (zeige SHH Proteine) signaling, which plays a crucial role in both development and tumorigenesis.
Similar phenotypes were observed by conditionally misexpressing a dominant negative form of MAML1 in Mitral cells ( MCs (zeige SMCP Proteine))after their migration. Furthermore, the intracellular domain of Notch1 (zeige NOTCH1 Proteine) (NICD1) was localized to nuclei of MCs (zeige SMCP Proteine). These findings suggest that Notch (zeige NOTCH1 Proteine) signaling at embryonic stages is involved in the dendritic complexity of MCs (zeige SMCP Proteine)
These observations suggest that chondrocyte maturation was impaired in MAML1(-/-) mice. MAML1 enhances the transcriptional activity of Runx2 (zeige RUNX2 Proteine) and plays a role in bone development.
This study demonstrated that targeting Maml1-induced tumor cell senescence and differentiation may alter the tumor microenvironment and cytokine and chemokine (zeige CCL1 Proteine) profiles and may also promote innate and adaptive immune cell infiltration and function.
Maml-mediated Notch (zeige NOTCH1 Proteine) signaling plays a pivotal role in the initiation and maintenance of goblet cell differentiation for normal ocular surface morphogenesis.
Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo.
Data demonstrate that Mesp2 (zeige Mesp2 Proteine) potently represses Notch (zeige NOTCH1 Proteine) signaling by inducing the destabilization of mastermind-like 1, a core regulator of this pathway.
MAML1 is a novel modulator for NF-kappaB (zeige NFKB1 Proteine) signaling and regulates cellular survival.
There seems to be close correlation of the spatial and temporal expression of Maml1, in the central nervous system (CNS) during early development, implicating a role for the Maml1 gene in neurogenesis.
a dominant negative mutant of MAML1 resulted in early inhibition of T-cell development and the appearance of intrathymic B cells, phenotypes consistent with Notch1 (zeige NOTCH1 Proteine) inhibition
The divergence of E6 proteins from either MAML1 or E6AP (zeige ube3a Proteine) binding preference is a major event in papillomavirus evolution.
Authors report that p300 (zeige EP300 Proteine) and CBP (zeige CREBBP Proteine) acetylate Mastermind-like 1 (Maml1) on amino acid residues K188 and K189 to recruit NACK to the Notch1 (zeige NOTCH1 Proteine) ternary complex, which results in the recruitment of RNA polymerase II to initiate transcription.
MAML1 may play an important role in tumor progression of Hepatocellular Carcinoma.
Notch (zeige NOTCH1 Proteine) signaling was altered in almost half of the clear-cell renal cell carcinoma (zeige MOK Proteine) patients and copy number variances in MAML1 and KAT2B (zeige KAT2B Proteine) were predominant changes.
The transcriptional coregulator MAML1 affects DNA methylation (zeige HELLS Proteine) and gene expression patterns in human embryonic kidney cells.
study identifies that MAML1 is ubiquitinated in the absence of Notch (zeige NOTCH1 Proteine) signaling to maintain low levels of MAML1 in the cell
In MCF-7 cells p53 (zeige TP53 Proteine) associates with the Notch (zeige NOTCH1 Proteine) transcriptional complex (NTC) in a MAML1-dependent fashion, most likely through a p53 (zeige TP53 Proteine)-MAML1 interaction.
The impact of MAML1 genetic variants to heart rate was discovered.
Data indicate that EpCAM (zeige EPCAM Proteine), CK19 (zeige KRT19 Proteine), and hMAM triple-marker-positive circulating tumor cells (CTCs) were detected in 86 of 98 (87.8 %) patients.
Snail (zeige SNAI1 Proteine) decreased transcription of Notch1 (zeige NOTCH1 Proteine) intracellular domain (NICD (zeige NOTCH1 Proteine)) target genes via competing with MAML1, co-activator, in NICD (zeige NOTCH1 Proteine) complex.
This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.
, mastermind-like 1
, mastermind-like protein 1
, mastermind homolog