anti-CRB3 (CRB3) Antikörper

Human Crumbs Homolog 3 (Drosophila) (CRB3) Interaktionspartner

1. we report for the first time that CRB3 acts as an upstream regulator of the Hippo pathway to regulate contact inhibition by recruiting other Hippo molecules, such as Kibra (zeige WWC1 Antikörper) and/or FRMD6 (zeige FRMD6 Antikörper), in mammary epithelial cells.

2. CRB3A recruits p114RhoGEF (zeige ARHGEF18 Antikörper) and its activator Ehm2 to the cell periphery using both functional motifs of its cytoplasmic tail and increases RhoA (zeige RHOA Antikörper) activation levels.

3. our data demonstrated that CRB3 may be used as a new independent favorable prognostic factor for human ccRCC

4. Morg1 (zeige wdr83 Antikörper) facilitates Par6 (zeige PARD6A Antikörper)-aPKC binding to Crb3 for definition of apical identity of epithelial cells.

5. the Crumbs3-Pals1 (zeige MPP5 Antikörper) complex has a role in development of polarity in mammalian epithelial cells

6. CRB3, through its cytoplasmic domain and its interactors, plays a role in apical membrane morphogenesis and tight junction regulation.

7. Data show that a novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta1 interactions.

8. overexpression of human CRB1 (zeige CRB1 Antikörper) and related isoforms, CRB2 (zeige CRB2 Antikörper) and CRB3, had no effect on the levels of presenilin complex components, on NCT (zeige NCSTN Antikörper) maturation or on PS endoproteolysis

Mouse (Murine) Crumbs Homolog 3 (Drosophila) (CRB3) Interaktionspartner

1. YAP (zeige YAP1 Antikörper) promotes myelin and non-myelin genes transcription while the polarity protein Crb3, localized at the tips of the myelin sheath, activates the Hippo pathway to temper YAP (zeige YAP1 Antikörper) activity, therefore allowing for optimal myelin growth.

2. Crb3 knockdown in mammalian cells affects the dynamics of IFT particle movement.

3. Crb3, a Crumbs isoform that determines epithelial apical domain identity, is required for airway differentiation by controlling the localization of the transcriptional regulator Yap (zeige YAP1 Antikörper).

4. The presence of Crb3 in many organs and the regularity of Crb3 distribution in the process of mouse embryonic development indicate that Crb3 protein plays an important role in establishing and maintaining the polarity of mouse embryos.

5. Data indicate that Crb3 (Crumbs3) is crucial for epithelial morphogenesis and plays a role in linking the apical membrane to the underlying ezrin (zeige EZR Antikörper)-containing cytoskeleton.

6. the presence of CRB3 protein in the mouse retina

7. Data show the deletion of Pals1 (zeige MPP5 Antikörper) leads to the disruption of the apical localization of Crb polarity complex proteins Crb1 (zeige CRB1 Antikörper), Crb2 (zeige CRB2 Antikörper) and Crb3 in retinal progenitors and the adult retina.