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Human Polyclonal CRB1 Primary Antibody für ELISA, WB - ABIN565074
Pardossi-Piquard, Chen, Silva-Gagliardi, Szego, McInnes, McGlade, St George-Hyslop, Fraser: Overexpression of human CRB1 or related isoforms, CRB2 and CRB3, does not regulate the human presenilin complex in culture cells. in Biochemistry 2007
This study show that the undifferentiated CNS expresses Crb1, Crb2a, and Crb2b in distinct spatial and temporal patterns.
Data suggest that the Crb (zeige MYBL2 Antikörper)/Moe (zeige EPB41L5 Antikörper) complex and Notch (zeige NOTCH1 Antikörper) play roles in a positive feedback loop to maintain the apicobasal polarity in neuroepithelial cells.
Several Crb mutant proteins accumulated abnormally in the rhabdomere and affected rhodopsin (zeige RHO Antikörper) trafficking, suggesting that abnormal rhodopsin (zeige RHO Antikörper) physiology contributes to Crb/CRB1-associated retinal degeneration.
Novel compound heterozygous mutations found in CRB1 were identified in a Chinese pedigree with Autosomal-recessive retinitis pigmentosa using targeted-capture next generation sequencing.
Retinal capillaritis, vitritis, and cystoid macular edema could be inflammatory features of CRB1 retinal dystrophy (zeige MERTK Antikörper) in our young patient.
In summary, mutations in CRB1 need to be considered as a potential cause of isolated maculopathy, particularly in cases where the central macular atrophy is associated with paracentral macular thickening and loss of normal lamination on OCT (zeige Plxna2 Antikörper).
The traditional village therapy may have compromised retinal venous outflow and/or provoked a Valsalva phenomenon, leading to the bilateral retinal hemorrhages. The fact that this occurred bilaterally and in both sisters supports the concept of relative vessel wall incompetence as part of CRB1-related retinopathy.
Mutations in the CRB1 gene are associated with a spectrum of progressive retinal degeneration. Visual acuity survival analyses indicate that the optimal intervention window for subretinal gene therapy is within the first 2 to 3 decades of life.
This is the first report to implicate CRB1 as the underlying cause of FFR (zeige VPS51 Antikörper). This phenotype forms the mildest end of the spectrum of CRB1-related diseases.
The first study reporting on the molecular genetic cause of non-syndromic early-onset severe retinal dystrophy (zeige MERTK Antikörper) in Czech patients identified one homozygous and two compound heterozygote probands with CRB1 mutations.
We present the case of a child who presented during screening for uveitis associated with juvenile idiopathic arthritis with macular oedema and was found to have early onset retinal dystrophy (zeige MERTK Antikörper) and mutations in CRB1.
Two novel variants were detected: c.2536G>T (p.G846X) in the CRB1 gene and c.4929delA (p.Lys1643fsX2) in the CEP290 (zeige CEP290 Antikörper) gene.
a new function of RNF146 (zeige RNF146 Antikörper) and tankyrase in stabilizing the Crumbs complex through downregulation of AMOT (zeige AMOT Antikörper) proteins at the apical membrane, is reported.
This study showed that The geographic distribution of subretinal microglia/macrophages changes with age in both Crb1 rd8/rd8 and C57BL mice, but the total number of microglia only increases in Crb1 rd8/rd8 mice,and pro-inflamatory phenotype.
The retinal phenotype of Grk1 (zeige GRK1 Antikörper)-/- mice is compromised by a Crb1 rd8 mutation.
Presence of rd8 (Crb1) mutation does not alter the ocular phenotype of late-onset retinal degeneration mouse model carrying the Ctrp5 (zeige C1QTNF5 Antikörper) mutation.
Study showed that CRB1 and CRB2 (zeige CRB2 Antikörper) in human retinas have an opposite pattern of expression in Muller glia and photoreceptor cells compared with mouse retinas, and that Crb2 (zeige CRB2 Antikörper) influences the severity of the murine Crb1-linked retinal dystrophies.
These findings suggest that CRB1 and CRB2 (zeige CRB2 Antikörper) suppress late progenitor pool expansion by regulating multiple proliferative signaling pathways.
The C57BL/6NJ-Crb1(rd8) mutation and its associated retinal phenotypes were corrected efficiently by TALEN-mediated homology-directed repair.
This study demonistrated that the Rd8 mutation in the Crb1 gene of CD11c (zeige ITGAX Antikörper)-eYFP transgenic reporter mice results in abnormal numbers of CD11c (zeige ITGAX Antikörper)-positive cells in the retina.
Data show the deletion of Pals1 (zeige MPP5 Antikörper) leads to the disruption of the apical localization of Crb polarity complex proteins Crb1, Crb2 (zeige CRB2 Antikörper) and Crb3 (zeige CRB3 Antikörper) in retinal progenitors and the adult retina.
CRB1 mutations lead to early-onset severe loss of vision with thickened, disorganized, nonseeing retina. Impaired peripheral vision can persist in late disease stages.
This gene encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. In Drosophila crumbs localizes to the stalk of the fly photoreceptor and may be a component of the molecular scaffold that controls proper development of polarity in the eye. Mutations in this gene are associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis. Alternate splicing results in multiple transcript variants, some protein coding and some non-protein coding.
crumbs homolog 1 (Drosophila)
, crumbs homolog 1
, crumbs-like 1
, crumbs homolog 1-like
, protein crumbs homolog 1