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anti-Human TRAF1 Antikörper:
anti-Mouse (Murine) TRAF1 Antikörper:
anti-Rat (Rattus) TRAF1 Antikörper:
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Human Polyclonal TRAF1 Primary Antibody für IHC (p), IHC - ABIN251285
Pryhuber, Huyck, Staversky, Finkelstein, OReilly: Tumor necrosis factor-alpha-induced lung cell expression of antiapoptotic genes TRAF1 and cIAP2. in American journal of respiratory cell and molecular biology 2000
Show all 2 Pubmed References
Human Polyclonal TRAF1 Primary Antibody für IF (p), IHC (p) - ABIN673464
Wang, Luo, Pan, Huang, Lv, Guo, Xu, Shen: Comparative genomic study of gastric epithelial cells co-cultured with Helicobacter pylori. in World journal of gastroenterology : WJG 2013
Human Polyclonal TRAF1 Primary Antibody für IHC, IHC (p) - ABIN4361647
Verma, Shet, Epari, Gupta, Gujral, Khanna, Laskar, Sengar, Arora, Menon, Banavali: Mediastinal Gray Zone Lymphoma: A Wider Category Than We Think? in International journal of surgical pathology 2016
Cow (Bovine) Polyclonal TRAF1 Primary Antibody für IHC, IHC (p) - ABIN4361646
Zapata, Krajewska, Krajewski, Kitada, Welsh, Monks, McCloskey, Gordon, Kipps, Gascoyne, Shabaik, Reed: TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies. in Journal of immunology (Baltimore, Md. : 1950) 2000
Rbf1-induced apoptosis activates a compensatory proliferation mechanism which also depends on Slipper and TRAF1, indicating that these two proteins seem to be key players of compensatory proliferation in Drosophila.
Traf4 is expressed throughout development, and is required for efficient apical constrictions of ventral furrow cells.
Expression of Reaper leads to a loss of DIAP1 (zeige DIAPH1 Antikörper) inhibition of DTRAF1-mediated JNK (zeige MAPK8 Antikörper) activation in Drosophila cells.
DTRAF1-null mutant showed a remarkable reduction in JNK (zeige MAPK8 Antikörper) activity with an impaired development of imaginal discs and a defective formation of photosensory neuron arrays.
TRAF1 functions as a positive regulator of insulin (zeige INS Antikörper) resistance, inflammation, and hepatic steatosis dependent on the activation of ASK1 (zeige MAP3K5 Antikörper)-P38 (zeige CRK Antikörper)/JNK (zeige MAPK8 Antikörper) axis.
The structure reveals both similarities and differences with other TRAF family members, which may be functionally relevant to TRAFs. The authors also found that the TRAF-N coiled-coil domain of TRAF1 is critical for the trimer formation and stability of the protein.
this study reveals an unexpected role for TRAF1 in negatively regulating Toll-like receptor signaling, providing a mechanistic explanation for the increased inflammation seen with a rheumatoid arthritis-associated single-nucleotide polymorphism in the TRAF1 gene
H. pylori infection significantly inhibits the cleavage of TRAF1 via a CagA (zeige S100A8 Antikörper)-dependent mechanism, which would increase the relative amounts of full-length TRAF1 and exert an antiapoptotic effect on H. pylori-infected cells.
Alleles of rs2416804 in TRAF1 were identified as being linked and associated with carotid intima-media thickness.
Molecular basis for TANK recognition by TRAF1 revealed by the crystal structure of TRAF1/TANK complex has been reported.
Single nucleotide polymorphisms (SNP) in angiotensin II receptor, type 1 (AGTR1 (zeige AGTR1 Antikörper)), transcription factor AP-2 beta (TFAP2B (zeige TFAP2B Antikörper)), and tumor necrosis factor (zeige TNF Antikörper) receptor-associated factor 1 (TRAF1) have been reported to be associated with the incidence of PDA in preterm infants.
TRAF1 plays a crucial role in the pathogenesis of autoantibodies and may serve as a serologic inflammatory marker of disease activity in rheumatoid arthritis patients.
Helicobacter pylori infection induces the overexpression of TRAF1 in gastric epithelial cells. The upregulation of TRAF1 plays an antiapoptotic role in Helicobacte pylori -infected gastric cells and may contribute to the gastric carcinogenesis.
The increased serum TRAF-1 may be a useful non-invasive indicator of Renal cell carcinoma (zeige MOK Antikörper) (RCC (zeige XRCC1 Antikörper)) development.
this study shows that Traf1 gene knock-out mice show increased susceptibility to lipopolysaccharide-induced septic shock
NFkappaB anti-apoptotic target genes TNF receptor-associated factor 1 (TRAF1), TNF receptor-associated factor 2 (TRAF2 (zeige TRAF2 Antikörper)), cellular inhibitor of apoptosis (cIAP2 (zeige BIRC3 Antikörper)), and Ferritin heavy chain (FTH1 (zeige FTH1 Antikörper)) were increased following Losartan treatment
TRAF1 is a crucial early mediator of hepatic ischemia/reperfusion injury.
Increased neuronal TRAF1 leads to elevated neuronal death and enlarged ischaemic lesions.
The pathogenesis of spontaneous KRN/I-A(g7) arthritis can largely proceed by TRAF1-independent pathways.
Together, these findings define the importance of the basal phosphorylation state of the TRAF1 Serine 139 residue in coordinating signalling events downstream of 4-1BB (zeige TNFRSF9 Antikörper) in primary T cells.
TRAF1 and LSP1 (zeige LSP1 Antikörper) cooperate downstream of 4-1BB (zeige TNFRSF9 Antikörper) to activate ERK (zeige EPHB2 Antikörper) signaling and down-modulate the levels of Bim (zeige BCL2L11 Antikörper) leading to enhanced T cell survival.
TRAF1 plays a critical role in regulating T cell activation both through restricting the costimulation independent activation of NIK (zeige MAP4K4 Antikörper) in activated T cells and by promoting the 4-1BB (zeige TNFRSF9 Antikörper)-induced classical NF-kappaB (zeige NFKB1 Antikörper) pathway.
These findings identify TRAF1 as a potential biomarker of HIV-specific CD8 (zeige CD8A Antikörper) T cell fitness during the chronic phase of disease and a target for therapy.
combined signaling from the TNF (zeige TNF Antikörper) or IL-1 (zeige IL1A Antikörper) receptors promotes maximal lung inflammation that may contribute to the severity of disease caused by H5N1 virus infection
The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins\; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene.
, TNF receptor associated factor 1
, TNF-receptor-associated factor 1
, Epstein-Barr virus-induced protein 6
, TNF receptor-associated factor 1
, TNF receptor-associated factor 1-like
, Epstein-Bar virus-induced protein 6