anti-TRAF1 (TRAF1) Antikörper

Fruit Fly (Drosophila melanogaster) TNF Receptor-Associated Factor 1 (TRAF1) Interaktionspartner

1. Rbf1-induced apoptosis activates a compensatory proliferation mechanism which also depends on Slipper and TRAF1, indicating that these two proteins seem to be key players of compensatory proliferation in Drosophila.

2. Traf4 is expressed throughout development, and is required for efficient apical constrictions of ventral furrow cells.

3. Expression of Reaper leads to a loss of DIAP1 inhibition of DTRAF1-mediated JNK activation in Drosophila cells.

4. DTRAF1-null mutant showed a remarkable reduction in JNK activity with an impaired development of imaginal discs and a defective formation of photosensory neuron arrays.

Human TNF Receptor-Associated Factor 1 (TRAF1) Interaktionspartner

1. The authors found that tumor necrosis factor receptor-associated factor 2 (TRAF2), as well as TRAF1 and 3, directly binds to the active caspase-2 dimer.

2. The data suggest that miR-483 is a colorectal cancer suppressor which could inhibit cell proliferation and migration, possibly via targeting TRAF1.

3. Results showed that TRAF1 was frequently upregulated in NSCLC tissues compared with adjacent non-cancerous lung tissues. TRAF1 expression was positively associated with NSCLC lymphatic metastasis and histological grade and was negatively associated with overall patient survival.

4. TRAF1, CTGF, and CX3CL1 genes are hypomethylated in osteoarthritis

5. Authors demonstrated that TRAF1 expression had no significant prognostic value for GBM.

6. TRAF1 functions as a positive regulator of insulin resistance, inflammation, and hepatic steatosis dependent on the activation of ASK1-P38/JNK axis.

7. The structure reveals both similarities and differences with other TRAF family members, which may be functionally relevant to TRAFs. The authors also found that the TRAF-N coiled-coil domain of TRAF1 is critical for the trimer formation and stability of the protein.

8. this study reveals an unexpected role for TRAF1 in negatively regulating Toll-like receptor signaling, providing a mechanistic explanation for the increased inflammation seen with a rheumatoid arthritis-associated single-nucleotide polymorphism in the TRAF1 gene

9. H. pylori infection significantly inhibits the cleavage of TRAF1 via a CagA-dependent mechanism, which would increase the relative amounts of full-length TRAF1 and exert an antiapoptotic effect on H. pylori-infected cells.

10. Alleles of rs2416804 in TRAF1 were identified as being linked and associated with carotid intima-media thickness.

11. Molecular basis for TANK recognition by TRAF1 revealed by the crystal structure of TRAF1/TANK complex has been reported.

12. Single nucleotide polymorphisms (SNP) in angiotensin II receptor, type 1 (AGTR1), transcription factor AP-2 beta (TFAP2B), and tumor necrosis factor receptor-associated factor 1 (TRAF1) have been reported to be associated with the incidence of PDA in preterm infants.

13. TRAF1 plays a crucial role in the pathogenesis of autoantibodies and may serve as a serologic inflammatory marker of disease activity in rheumatoid arthritis patients.

14. Helicobacter pylori infection induces the overexpression of TRAF1 in gastric epithelial cells. The upregulation of TRAF1 plays an antiapoptotic role in Helicobacte pylori -infected gastric cells and may contribute to the gastric carcinogenesis.

15. The increased serum TRAF-1 may be a useful non-invasive indicator of Renal cell carcinoma (RCC) development.

16. Data suggest that, during B-cell transformation by Epstein-Barr virus, LMP1 (EBV latent membrane protein 1) induces signaling that stimulates Lys63-polyubiquitin chain attachment to TRAF1 (TNF receptor-associated factor 1) in the B-lymphocytes.

17. This study did not replicate the association between PTPRC and the response to anti-TNF treatment in our Southern European population. We found that TRAF1/C5 risk RA variants potentially influence anti-TNF treatment response.

18. Rs2900180 in C5-TRAF1 and linked variants in a 66Kb region were associated with radiographic progression in ACPA-negative RA

19. TRAF1/C5 rs10818488 polymorphism is not a genetic risk factor for acquired aplastic anemia in a Chinese population.

20. TRAF1-ALK translocation contributes to neoplastic phenotype in anaplastic large-cell lymphoma.

Mouse (Murine) TNF Receptor-Associated Factor 1 (TRAF1) Interaktionspartner

1. The authors demonstrated that miR-23b mediated immunosuppression during late sepsis by inhibiting the noncanonical NF-kappaB signal and promoting the proapoptotic signal pathway by targeting NIK, TRAF1, and XIAP.

2. TRAF-1-/- mice fed with high fat diet failed to gain weight, and showed improved insulin resistance, increased lipid breakdown in adipocytes and UCP-1-enabled thermogenesis.

3. this study shows that Traf1 gene knock-out mice show increased susceptibility to lipopolysaccharide-induced septic shock

4. NFkappaB anti-apoptotic target genes TNF receptor-associated factor 1 (TRAF1), TNF receptor-associated factor 2 (TRAF2), cellular inhibitor of apoptosis (cIAP2), and Ferritin heavy chain (FTH1) were increased following Losartan treatment

5. TRAF1 is a crucial early mediator of hepatic ischemia/reperfusion injury.

6. Increased neuronal TRAF1 leads to elevated neuronal death and enlarged ischaemic lesions.

7. The pathogenesis of spontaneous KRN/I-A(g7) arthritis can largely proceed by TRAF1-independent pathways.

8. Together, these findings define the importance of the basal phosphorylation state of the TRAF1 Serine 139 residue in coordinating signalling events downstream of 4-1BB in primary T cells.

9. TRAF1 and LSP1 cooperate downstream of 4-1BB to activate ERK signaling and down-modulate the levels of Bim leading to enhanced T cell survival.

10. TRAF1 plays a critical role in regulating T cell activation both through restricting the costimulation independent activation of NIK in activated T cells and by promoting the 4-1BB-induced classical NF-kappaB pathway.

11. These findings identify TRAF1 as a potential biomarker of HIV-specific CD8 T cell fitness during the chronic phase of disease and a target for therapy.

12. combined signaling from the TNF or IL-1 receptors promotes maximal lung inflammation that may contribute to the severity of disease caused by H5N1 virus infection

13. TRAF1 deficiency attenuates atherogenesis in mice, most likely owing to impaired monocyte recruitment to the vessel wall

14. TRAF1 reglates the subcellular localization and reveals mechanism of TRAF2 signaling.

15. TRAF1 limit the induction of Th2 responses by decreasing NIP45 concentration to the nucleus down-regulating the expression of NIP45-dependent IL-4 gene transcription.

16. cellular levels of TRAF1 may play an important role in modulating the degradation of TRAF2 and TRAF3 in response to signals from the TNFR superfamily

17. The TRAF1 signaling axis is critical for CD8 memory T cell survival in vivo.

18. Results implicate endothelial TRAF-1, -2, -3, -5, and -6 in CD40 signaling in atherogenesis, identifying these molecules as potential targets for selective therapeutic intervention.

19. The expression of TRAF1 in resident lung cells is required for the development of asthma.

20. TRAF1 has a prosurvival effect in CD8 T cells via the 4-1BB-mediated up-regulation of anti-apoptosis regulatory protein Bcl-x(L) and extracellular-regulated MAP kinase (ERK)-dependent Bim apoptosis facilitator down-modulation.