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Human Polyclonal PKC zeta Primary Antibody für ICC, IF - ABIN4345863
Verbist, Guy, Milasta, Liedmann, Kamiński, Wang, Green: Metabolic maintenance of cell asymmetry following division in activated T lymphocytes. in Nature 2016
Human Polyclonal PKC zeta Primary Antibody für IHC (p) - ABIN2476259
Hirai, Chida: Protein kinase Czeta (PKCzeta): activation mechanisms and cellular functions. in Journal of biochemistry 2003
Human Polyclonal PKC zeta Primary Antibody für IHC (p), WB - ABIN391018
Lerner-Marmarosh, Miralem, Gibbs, Maines: Regulation of TNF-alpha-activated PKC-zeta signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductase. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007
Protein kinase c (zeige PKC Antikörper) activity restricts dendritic arborization during embryonic brain circuit development through synaptotropic stabilization of dynamic processes.
PKCzeta promoted lung adenocarcinoma invasion and metastasis, and its expression was associated with MMP2 (zeige MMP2 Antikörper) and MMP9 (zeige MMP9 Antikörper) expression.
PKC-zeta may be responsible for the abnormal growth, proliferation, and migration of metastatic LOVO colon cancer cells via PKC-zeta/Rac1/Pak1 (zeige PAK1 Antikörper)/beta-Catenin (zeige CTNNB1 Antikörper) pathway.
reduced expression of PKCzeta/Pard3 (zeige PARD3 Antikörper)/Pard6 contributes to non-small-cell lung cancer epithelial-mesenchymal transition, invasion, and chemoresistance.
Intestinal I/R induced the membrane translocation and phosphorylation of PKCzeta. Pretreatment with the PKCzeta activator phosphatidylcholine (zeige SGMS2 Antikörper) remarkably attenuated gut (zeige GUSB Antikörper) injury by suppressing apoptosis. H/R induced PKCzeta to combine with TRAF2 (zeige TRAF2 Antikörper), which was phosphorylated by PKCzeta at Ser (zeige SIGLEC1 Antikörper)(55), but not at Ser (zeige SIGLEC1 Antikörper)(11), under intestinal I/R or H/R conditions
these results conclude that miR (zeige MLXIP Antikörper)-25 targets PKCzeta and protects osteoblastic cells from Dex via activating AMPK (zeige PRKAA1 Antikörper) signaling.
PKCzeta was specifically involved in ACOT7 (zeige ACOT7 Antikörper) depletion-mediated cell cycle arrest as an upstream molecule of the p53 (zeige TP53 Antikörper)-p21 (zeige CDKN1A Antikörper) signaling pathway in MCF7 human breast carcinoma and A549 human lung carcinoma cells.
we found that Wnt3a (zeige WNT3A Antikörper) treatment rapidly induces hyperphosphorylation and stabilization of Dvl2 (zeige DVL2 Antikörper) and Dvl3 (zeige DVL3 Antikörper). Our findings suggest a model of positive regulation of PKCzeta-mediated Dvl (zeige DVL2 Antikörper) signaling activity, to produce a strong and sustained response to Wnt3a (zeige WNT3A Antikörper) treatment by stabilizing Dvl (zeige DVL2 Antikörper) protein levels.
The data demonstrate that PKCzeta expression regulates the maturation of neonatal T-cells into specific functional phenotypes and that environmental influences may work via PKCzeta to regulate these phenotypes and disease susceptibility.
This study demonstrated that zinc upregulates PKCzeta by activating GPR39 (zeige GPR39 Antikörper) to enhance the abundance of ZO-1 (zeige TJP1 Antikörper), thereby improving epithelial integrity in S. typhimurium-infected Caco-2 cells.
Inhibition of protein kinase C zeta expression in prostate cancer cells promoted chemotaxis of peripheral macrophages and acquisition of M2 phenotypic features. These results were further supported by the finding that silencing of endogenous protein kinase C zeta promoted the expression of prostate cancer cell-derived interleukin-4 (zeige IL4 Antikörper) and interleukin-10 (zeige IL10 Antikörper)
HIF regulation of HOIL-1L (zeige RBCK1 Antikörper) targets the phosphorylated PKC-zeta for degradation and serves as an hypoxia-adaptive mechanism to stabilize the Na,K-ATPase (zeige ATP1A1 Antikörper), avoiding significant lung injury.
Under physiological conditions, PKMzeta is the principal PKC (zeige PKC Antikörper) isoform that maintains LTP (zeige SCP2 Antikörper) and long-term memory. PKCiota/lambda can compensate for PKMzeta, and because other isoforms could also maintain synaptic facilitation, there may be a hierarchy of compensatory mechanisms maintaining memory if PKMzeta malfunctions. [Review]
aPKCzeta is required for the cellular organization of acto-non-muscle myosin II (NMII) cytoskeleton, for proper cell adhesion and directed cell migration.
This study demonstrates that the combination therapy of PKCzeta and COX-2 (zeige COX2 Antikörper) inhibitors can significantly inhibit melanoma metastasis in vitro and in vivo, which will be an efficient strategy for treatment of melanoma metastasis in clinics
the inhibition of PKCzeta or ceramide synthesis did not further improve glucose tolerance in Angptl4 (zeige ANGPTL4 Antikörper)(-/-) mice, suggesting that these molecules were major downstream effectors of Angptl4 (zeige ANGPTL4 Antikörper).
Immunoblotting, qPCR, ChIP and siRNA-mediated gene knockdown studies revealed that the activation of phosphatidylinositol 3-kinase/protein kinase C zeta pathways in poly(I:C)-stimulated cells underlies Sp1 (zeige SP1 Antikörper) phosphorylation and recruitment to the mCRAMP promoter, leading to enhanced transcription
APPL1 (zeige APPL1 Antikörper) enhances glucose uptake by modulating the activation and localization of PKCzeta, as well as its functional interaction with both PP2A (zeige PPP2R2B Antikörper) and myosin IIa.
Findings indicate PDZRN3 (zeige PDZRN3 Antikörper) regulates vascular permeability through a PKCzeta-containing complex.
Data (including data from studies in transgenic and knockout mice) suggest that Pkcz (protein kinase C zeta) activation is key for early compensatory pancreatic beta-cell proliferation in insulin (zeige INS Antikörper) resistance (overweight and diabetes type 2) by regulating downstream signal transduction components mTOR (mammalian target of rapamycin (zeige FRAP1 Antikörper) protein) and Ccnd2 (cyclin-D2 (zeige CCND2 Antikörper)).
These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.
chronic exposure to hypoxia leads to the emergence of cells lacking anti-replication activity of PKCzeta in the pulmonary artery adventitia.
inhibition of NO production by Ang-1 (zeige ANGPT1 Antikörper), via phosphorylation of eNOS (zeige NOS3 Antikörper) on Thr (zeige TRH Antikörper)(497) by PKC zeta, is responsible, at least in part, for inhibition of VEGF (zeige VEGFA Antikörper)-stimulated endothelial permeability by Ang-1 (zeige ANGPT1 Antikörper).
ceramide as a potent physiological modulator of the Na(+)-ATPase (zeige DNAH8 Antikörper), participating in a regulatory network in kidney cells and counteracting the stimulatory effect of PKA via PKCzeta.
Zebrafish pronephros tubulogenesis and epithelial identity maintenance are reliant on the polarity proteins Prkc iota and zeta.
Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.
protein kinase C, zeta
, protein kinase c type Z
, protein kinase C zeta type
, protein kinase C zeta type-like
, atypical protein kinase C
, protein kinase C zeta subspecies
, 14 - 3 - 3 - zeta isoform
, atypical protein kinase C zeta