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anti-Human PKC zeta Antikörper:
anti-Mouse (Murine) PKC zeta Antikörper:
anti-Rat (Rattus) PKC zeta Antikörper:
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Human Polyclonal PKC zeta Primary Antibody für ICC, IF - ABIN4345863
Verbist, Guy, Milasta, Liedmann, Kamiński, Wang, Green: Metabolic maintenance of cell asymmetry following division in activated T lymphocytes. in Nature 2016
Human Polyclonal PKC zeta Primary Antibody für IHC (p) - ABIN2476259
Hirai, Chida: Protein kinase Czeta (PKCzeta): activation mechanisms and cellular functions. in Journal of biochemistry 2003
Human Polyclonal PKC zeta Primary Antibody für IHC (p), WB - ABIN391018
Lerner-Marmarosh, Miralem, Gibbs, Maines: Regulation of TNF-alpha-activated PKC-zeta signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductase. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007
Protein kinase c (zeige PKC Antikörper) activity restricts dendritic arborization during embryonic brain circuit development through synaptotropic stabilization of dynamic processes.
Intestinal I/R induced the membrane translocation and phosphorylation of PKCzeta. Pretreatment with the PKCzeta activator phosphatidylcholine (zeige SGMS2 Antikörper) remarkably attenuated gut (zeige GUSB Antikörper) injury by suppressing apoptosis. H/R induced PKCzeta to combine with TRAF2 (zeige TRAF2 Antikörper), which was phosphorylated by PKCzeta at Ser (zeige SIGLEC1 Antikörper)(55), but not at Ser (zeige SIGLEC1 Antikörper)(11), under intestinal I/R or H/R conditions
these results conclude that miR (zeige MLXIP Antikörper)-25 targets PKCzeta and protects osteoblastic cells from Dex via activating AMPK (zeige PRKAA1 Antikörper) signaling.
PKCzeta was specifically involved in ACOT7 (zeige ACOT7 Antikörper) depletion-mediated cell cycle arrest as an upstream molecule of the p53 (zeige TP53 Antikörper)-p21 (zeige CDKN1A Antikörper) signaling pathway in MCF7 human breast carcinoma and A549 human lung carcinoma cells.
we found that Wnt3a (zeige WNT3A Antikörper) treatment rapidly induces hyperphosphorylation and stabilization of Dvl2 (zeige DVL2 Antikörper) and Dvl3 (zeige DVL3 Antikörper). Our findings suggest a model of positive regulation of PKCzeta-mediated Dvl (zeige DVL2 Antikörper) signaling activity, to produce a strong and sustained response to Wnt3a (zeige WNT3A Antikörper) treatment by stabilizing Dvl (zeige DVL2 Antikörper) protein levels.
The data demonstrate that PKCzeta expression regulates the maturation of neonatal T-cells into specific functional phenotypes and that environmental influences may work via PKCzeta to regulate these phenotypes and disease susceptibility.
This study demonstrated that zinc upregulates PKCzeta by activating GPR39 (zeige GPR39 Antikörper) to enhance the abundance of ZO-1 (zeige TJP1 Antikörper), thereby improving epithelial integrity in S. typhimurium-infected Caco-2 cells.
Inhibition of protein kinase C zeta expression in prostate cancer cells promoted chemotaxis of peripheral macrophages and acquisition of M2 phenotypic features. These results were further supported by the finding that silencing of endogenous protein kinase C zeta promoted the expression of prostate cancer cell-derived interleukin-4 (zeige IL4 Antikörper) and interleukin-10 (zeige IL10 Antikörper)
Here we provide the first evidence that PKC-zeta is a potential target for the treatment of COPD (zeige ARCN1 Antikörper) by selective small molecules
Study provides evidence for a novel PKC-zeta to p47phox interaction that is required for cell transformation from blebbishields and ROS (zeige ROS1 Antikörper) production in cancer cells.
FRET-based translocation assays reveal that insulin (zeige INS Antikörper) promotes the association of both p62 (zeige GTF2H1 Antikörper) and aPKC with the insulin (zeige INS Antikörper)-regulated scaffold IRS-1 (zeige IRS1 Antikörper).
the inhibition of PKCzeta or ceramide synthesis did not further improve glucose tolerance in Angptl4 (zeige ANGPTL4 Antikörper)(-/-) mice, suggesting that these molecules were major downstream effectors of Angptl4 (zeige ANGPTL4 Antikörper).
Immunoblotting, qPCR, ChIP and siRNA-mediated gene knockdown studies revealed that the activation of phosphatidylinositol 3-kinase/protein kinase C zeta pathways in poly(I:C)-stimulated cells underlies Sp1 (zeige SP1 Antikörper) phosphorylation and recruitment to the mCRAMP promoter, leading to enhanced transcription
APPL1 (zeige APPL1 Antikörper) enhances glucose uptake by modulating the activation and localization of PKCzeta, as well as its functional interaction with both PP2A (zeige PPP2R2B Antikörper) and myosin IIa.
Findings indicate PDZRN3 (zeige PDZRN3 Antikörper) regulates vascular permeability through a PKCzeta-containing complex.
Data (including data from studies in transgenic and knockout mice) suggest that Pkcz (protein kinase C zeta) activation is key for early compensatory pancreatic beta-cell proliferation in insulin (zeige INS Antikörper) resistance (overweight and diabetes type 2) by regulating downstream signal transduction components mTOR (mammalian target of rapamycin (zeige FRAP1 Antikörper) protein) and Ccnd2 (cyclin-D2 (zeige CCND2 Antikörper)).
androstenedione administration increased Akt1 (zeige AKT1 Antikörper) and PKC zeta phosphorylation in the muscle tissue of C57BL6 mice.
studies support a model wherein an alternative mechanism regulates PKCzeta-mediated insulin (zeige INS Antikörper) signalling that does not utilize conventional activation via agonist-evoked phosphorylation at the activation loop
PKCzeta/p62 (zeige GTF2H1 Antikörper) activation stimulated inflammatory cytokine production and enhanced IGF-I (zeige IGF1 Antikörper)-stimulated VSMC proliferation
Neuronal NF1 (zeige NF1 Antikörper)/RAS regulation of cyclic AMP (zeige TMPRSS5 Antikörper) requires atypical PKC zeta activation, which is perturbed in neurofibromatosis type 1 (zeige NF1 Antikörper).
These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.
chronic exposure to hypoxia leads to the emergence of cells lacking anti-replication activity of PKCzeta in the pulmonary artery adventitia.
inhibition of NO production by Ang-1 (zeige ANGPT1 Antikörper), via phosphorylation of eNOS (zeige NOS3 Antikörper) on Thr (zeige TRH Antikörper)(497) by PKC zeta, is responsible, at least in part, for inhibition of VEGF (zeige VEGFA Antikörper)-stimulated endothelial permeability by Ang-1 (zeige ANGPT1 Antikörper).
ceramide as a potent physiological modulator of the Na(+)-ATPase (zeige DNAH8 Antikörper), participating in a regulatory network in kidney cells and counteracting the stimulatory effect of PKA via PKCzeta.
Zebrafish pronephros tubulogenesis and epithelial identity maintenance are reliant on the polarity proteins Prkc iota and zeta.
Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.
protein kinase C, zeta
, protein kinase c type Z
, protein kinase C zeta type
, protein kinase C zeta type-like
, atypical protein kinase C
, protein kinase C zeta subspecies
, 14 - 3 - 3 - zeta isoform
, atypical protein kinase C zeta