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anti-Human MAP3K14 Antikörper:
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Human Polyclonal MAP3K14 Primary Antibody für IHC (p), ELISA - ABIN544141
Aronsson, Magnusson, Andersson, Karsten, Shibasaki, Lendon, Goate, Brookes: The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17. in Human genetics 1998
Show all 3 Pubmed References
we identify nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB)-inducing kinase (NIK) as a potential drug target driving NF-kappaB signaling and Merlin-deficient schwannoma genesis
Results indicated that MAP3K14 is a susceptibility gene for leprosy.
A TRAF3-NIK axis differentially regulates viral DNA vs RNA pathways in innate immune signaling.
Data show that breast cancer stem cells (BCSCs) expressed higher levels of NF-kappaB-inducing kinase (NIK).
These findings highlight the importance of NIK in tumor pathogenesis and invite new therapeutic strategies that attenuate mitochondrial dysfunction through inhibition of NIK and Drp1.
results suggest that changes in the relative concentrations of RelB, NIK:IKK1, and p100 during noncanonical signaling modulate this transitional complex and are critical for maintaining the fine balance between the processing and protection of p100.
report a detailed state-of-the-art mass spectrometry-based protein-protein interaction network including the noncanonical NF-kappaB signaling nodes TRAF2, TRAF3, IKKalpha, NIK, and NF-kappaB2/p100; also provide a differential interactome of NIK mutants that cause immunodeficiency
OLFM1 is a negative regulator of non-canonical NF-kappaB signalling by interacting with and inhibiting NIK. Thus, OLFM1 may serve as a valuable biomarker and therapeutic target for colorectal cancer (CRC) patients.
The expression of OTUD7B and NIK were negatively correlated in non-small cell lung cancer tumor samples. the higher expression of NIK was related to more lymph node metastasis and later TNM stage. high OTUD7B/low NIK index can predict an good prognosis.
NIK expression was significantly increased in the tumor tissue of patients with breast carcinoma, which may be an important factor that affects the prognosis of these patients.
This study identified two novel independent loci (MAP3K14 and CARD9) strongly associated with joint damage in Mexican Americans and European Americans and a few shared loci showing suggestive evidence for association.
The forced expression of NDRG2 in ATL cells down-regulates not only the canonical pathway by inhibiting AKT signaling but also the non-canonical pathway by inducing NF-kappaB-inducing kinase (NIK) dephosphorylation via the recruitment of PP2A
NIK(+) endothelial cells may play an important role in the persistence of synovitis
Data suggest microRNA302c, but not microRNA520e, promotes replication of influenza A virus H3N2 although the two microRNAs target same site of NFkappaB-inducing kinase (MAP3K14) 3prime untranslated region; studies were conducted in lung epithelial cells.
TWEAK induces noncanonical NF-kappaB signaling and signal-specific regulation of NIK mRNA expression.
by demonstrating a critical role of NIK in mediating NF-kappaB activation and BAG3 induction upon ST80/Bortezomib cotreatment, our study provides novel insights into mechanisms of resistance to proteotoxic stress in RMS
Loss-of-function mutations in NIK can cause B-cell lymphopenia, hypogammaglobulinemia, impaired ICOSL expression, and disordered T helper cell and NK cell function.
Membrane attack complexes activate noncanonical NF-kappaB by forming a novel Akt(+)NIK(+) signalosome on Rab5(+) endosomes.
Authors show that activation of NF-kappaB by Kaposi's sarcoma-associated herpesvirus K15 protein involves the recruitment of NF-kappaB-inducing kinase (NIK) and IKK alpha/beta to result in the phosphorylation of p65/RelA on Ser536.
NIK plays a key role in constitutive NF-kappaB activation and the progression of ovarian cancer cells
our data suggest a pivotal role for the NIK signaling axis in regulating dendritic cell functions in intestinal immunity and homeostasis.
Pathological activation of hepatic NIK likely blocks hepatocyte replication, contributing to liver disease progression.
Nik(-/-) mice could be useful as a spontaneous model of specific features of Eosinophilic esophagitis.
global or thymus-specific ablation of the NIK gene results in fatal autoimmune liver disease in mice.
constitutive activation of NIK in the hematopoietic system leads to bone marrow (BM) failure and postnatal lethality.
NIK pathways in both hepatocytes and immune cells act in concert to promote liver steatosis and glucose production in the setting of obesity.
this study demonstrates that although NIK is dispensable for thymocyte development, it has a cell-intrinsic role in regulating the homeostasis and function of peripheral T cells
Using a novel conditional mutant of NIK, the authors could show in vivo that NIK signaling in thymic epithelial cells is essential for the thymic hardwiring of gammadelta T cell cytokine production.
NIK not only contributes to lymphoid organogenesis, inflammation and cell survival but also to TNFR1/RIP1-dependent cell death independently of the alternative NF-kappaB pathway.
This study demonstrated that NFkappaB-inducing kinase inhibits NFkappaB activity specifically in neurons of the CNS.
results assign NIK-induced alternative NF-kappaB signaling a master regulatory role in B-cells, starting from the T1 stage and also show that B-1 B cells are less dependent on this pathway, presumably owing to the existence of alternative pathways yet to be determined
NIK, and thus probably the noncanonical NF-kappaB pathway, is critical to allow DCs to acquire the capacity to cross-present antigen and prime CD8 T cells after exposure to licensing stimuli.
Deletion of NIK in adult mice results in decreases in B cell populations in lymph nodes and spleen, similar to what is observed upon blockade of BAFF.
We identify NIK as a critical negative regulator of beta cell function, as pharmacological NIK activation results in impaired glucose-stimulated insulin secretion in mouse and human islets.
the NIK in thymic stroma may be critically involved in the differentiation of most NKT cell subsets (although the level of NIK dependence may vary among the subsets), and also the NIK in NKT-alphabeta cells may be dispensable for their effector function.
CHIP/TRAF3/NIK interactions recruit NIK to E3 ligase complexes for ubiquitination and degradation, thus maintaining NIK at low levels
The results suggest a pivotal role of NIK in the thymic stroma in establishing self-tolerance by orchestrating cross-talk between medullary thymic epithelial cells and dendritic cells as well as thymocytes.
This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.
, serine/threonine protein-kinase
, serine/threonine-protein kinase NIK
, NF kappa B-inducing kinase
, Nfkb inducing kinase
, protein kinase
, mitogen-activated protein kinase kinase kinase 14