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Results suggest that optimised lentiviral transduction of the insulin gene into primary canine mesenchymal stromal cells (cMSCs) renders these cells capable of secreting insulin over both the short- and long-term, in sufficient quantities in vitro to support their potential use in insulin gene therapy.
C-peptide-based measurements of insulin secretion are appropriate for assessing beta-cell function in SGLT2 (zeige SLC5A2 Proteine) inhibitor canagliflozin-treated participants.
Many studies provided evidence that circulating unmethylated INS DNA can be a potential noninvasive biomarker of beta cell mass loss in type 1 Diabetes. [review]
Upon stratifying the participants into tertiles by the Matsuda index, we observed an inhibitory relationship between the genetic risk score (GRS (zeige BCL2A1 Proteine)) and insulin secretion in low insulin sensitive but not in high insulin sensitive controls and treatment-naive Type 2 diabetes.
The possibility of using insulin as a biomarker to guide insulin-targeted interventions also should be taken into account
the concentrations of insulin, IGF-1 (zeige IGF1 Proteine), IGFBP-3 (zeige IGFBP3 Proteine) and their association with prostate size in patients with BPH (zeige GLI3 Proteine)
Elevated Unmethylated Insulin DNA Is associated with beta cell death.
These results provide new information on the role of human islet-derived extracellular vesicles in the regulation of insulin expression in differentiating induced pluripotent stem cell clusters.
our experiments reveal an insulin-dependent activation of MCH (zeige PMCH Proteine) neurons in obesity, which contributes via distinct mechanisms to the manifestation of impaired locomotor activity and insulin resistance.
These data support a role for islet NGF (zeige NGFB Proteine) in fine-tuning insulin secretion.
Study used well-tempered bias exchange metadynamics simulations to determine the equilibrium ensembles of an insulin molecule under amyloidogenic conditions of low pH and high temperature. The folded state of a single insulin molecule was shown to be the most stable, longest-lived state even under amyloidogenic conditions.
The findings are consistent with previous studies that indicate a link between Na,K-ATPase (zeige ATP1A1 Proteine) activity and SFK signaling.
PTPLAD1 (zeige PTPLAD1 Proteine) and AMPK (zeige PRKAA1 Proteine) are rapidly compartmentalized within the plasma membrane (PM) and Golgi/endosome fractions after insulin stimulation and that ATIC (zeige ATIC Proteine) later accumulates in the Golgi/endosome fraction.
Pdx-1 (zeige PDX1 Proteine), MafA (zeige MAFA Proteine) and NeuroD1 (zeige NEUROD1 Proteine) bind to the A, C and E elements in the insulin promoter and regulate the transcriptional activity of the insulin promoter.
The interplay of the adiponectin system, TNFalpha (zeige TNF Proteine) and insulin at a transcriptional level and, their effects on the adipogenic transcription factor PPARgamma (zeige PPARG Proteine), as well as on the activation of main insulin signaling pathways, is reported.
Thermodynamics of insulin unfolding have been quantified by differential scanning calorimetry and thermal unfolding measurements to determine the extent and nature of their stabilization of the insulin hexamer.
Exposing the hydrophobic core of insulin can induce the increase of amyloidogenicity and formation of higher-order polymerized fibrils, which is less toxic to membranes.
Data suggest that a mutation in INS (C94Y) results a transgenic disease model for the investigation of permanent neonatal diabetes.
The results show that modulation of plasma insulin levels by dietary carbohydrates seems possible in anabolic sows, but IGF-I (zeige IGF1 Proteine) levels are less easily modified.
insulin increased GCLc (zeige GCLC Proteine) promoter activity, which required a prerequisite increase or decrease in medium glucose
Insulin signaling role in skeletal muscle atrophy and autophagy in in transition and postpartum period
Differences between human and bovine insulin kinetics under shear
increased sensitivity to glucose clearance and skeletal muscle insulin signaling during dietary restriction
Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin (zeige LEP Proteine)-NPY (zeige NPY Proteine) and insulin signaling pathways.
Raman spectra of amino acids by Density Functional Theory method have been calculated. Experimental Raman spectra of insulin has been done. The simulated Raman spectrum of insulin is obtained from amino acid spectrum.
Contains Binding kinetics for insulin binding
Using synchrotron radiation (SR), the crystal structures of T6 bovine insulin complexed with Ni(2 (zeige VMP1 Proteine)+) and Cu(2+) were solved to 1.50 and 1.45 A resolution, respectively.
The present study examined the effect of insulin-mediated activation of the mammalian target of rapamycin (zeige FRAP1 Proteine) complex 1 (MTORC1) signaling network on the proliferation of primary culture of theca-interstitial (T-I) cells.
In-situ spectroscopic investigation of ultrasonic assisted unfolding and aggregation of insulin.
insulin supports early initiation of the mesodermal factor Brachyury (zeige TBX1 Proteine) and the signalling molecules Wnt3a (zeige WNT3A Proteine) and Wnt4 (zeige WNT4 Proteine) as well as the progression of mesoderm formation
Data show that type 1 diabetic blastocyst did not express insulin mRNA.
cTAGE5 deletion in pancreatic beta cells impairs proinsulin trafficking and insulin biogenesis in mice.
These results suggest that prolonged exposure to hyperglycemia in the Ins2(Akita+/-) mice leads to progressive testicular disruption mediated by testicular activin activity, rather than hormonal dysregulation.
report that EndMTs occur in the diabetic endothelium of Ins2Akita/wt mouse, and show that induction of sex determining region Y-box 2 (Sox2 (zeige SOX2 Proteine)) is a mediator of excess BMP signaling that results in activation of EndMTs and increased vascular calcification
Transplantation of transduced hematopoietic stem cells (HSCs) expressing proinsulin II prevents diabetes development.
Wnt3a increased the expression of NeuroD1 and Ins2 in the hypothalamus.
Data suggest that resveratrol acts on differentiating preadipocytes by inhibiting insulin signaling, mitochondrial biogenesis, and lipogenesis.
have characterized the distinctive sex-specific phenotypes exhibited by the ApoE(-/-):Ins2(+/Akita) mouse model and present evidence for the action of sex hormones on pancreatic beta-cell function
Data indicate that Src homology-2 domain containing protein B (SHB) deficiency causes a chronic increase in beta-cell focal adhesion kinase (FAK) activity that perturbs the normal insulin secretory characteristics of beta-cells.
Mouse Ins2 and Ins1 promoters were transiently activated in mouse fetal hepatocytes of embryonic days 13.5 and 16.5, respectively.
Data indicate that insulin/incomplete Freund's adjuvant (IFA) does not prevent but induces diabetes in RIP-CD80GP transgenic mice.
Temporal and spatial expression of two insulin genes (insa and insab) during early developmental stages.
These findings suggest that GHRL (zeige GHRL Proteine) regulates INS synthesis by mediating its action on growth hormone secretagogue-receptor (zeige GHSR Proteine) in the central nervous system and partly involved in carbohydrate-glycogen (zeige GYS2 Proteine) metabolism.
Our results indicate that in adult tilapia insulin expression is not restricted to the endocrine pancreatic cells, but also occurs in endocrine cells of the pituitary gland and in the neuronal cells of the brain.
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.