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anti-Human Insulin Antikörper:
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Buffalo (Bubalus) Polyclonal Insulin Primary Antibody für IEM, ICC - ABIN617877
Tay, Wong: Insulin-like immunoreactivity in the monkey spinal cord. in Acta anatomica 1992
Show all 44 Pubmed References
Human Monoclonal Insulin Primary Antibody für IHC (p) - ABIN3043651
Han, Qiu, Zhang, Kong, Wang, Wang, Li, Duan, Wang, Song, Wang: Transplantation of sertoli-islet cell aggregates formed by microgravity: prolonged survival in diabetic rats. in Experimental biology and medicine (Maywood, N.J.) 2009
Show all 20 Pubmed References
Cow (Bovine) Monoclonal Insulin Primary Antibody für CyTOF, FACS - ABIN4900790
Cucak, Grunnet, Rosendahl: Accumulation of M1-like macrophages in type 2 diabetic islets is followed by a systemic shift in macrophage polarization. in Journal of leukocyte biology 2014
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Cow (Bovine) Monoclonal Insulin Primary Antibody für FACS - ABIN4898619
Kalis, Bolmeson, Esguerra, Gupta, Edlund, Tormo-Badia, Speidel, Holmberg, Mayans, Khoo, Wendt, Eliasson, Cilio: Beta-cell specific deletion of Dicer1 leads to defective insulin secretion and diabetes mellitus. in PLoS ONE 2012
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Human Polyclonal Insulin Primary Antibody für EIA, FACS - ABIN372838
Madsen, Knauf, Gotfredsen, Pilling, Sjögren, Andersen, Andersen, de Boer, Manova, Barlas, Vundavalli, Nyborg, Knudsen, Moelck, Fagin: GLP-1 receptor agonists and the thyroid: C-cell effects in mice are mediated via the GLP-1 receptor and not associated with RET activation. in Endocrinology 2012
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Human Polyclonal Insulin Primary Antibody für IHC, IHC (p) - ABIN4326017
Lindskog, Asplund, Engkvist, Uhlen, Korsgren, Ponten: Antibody-based proteomics for discovery and exploration of proteins expressed in pancreatic islets. in Discovery medicine 2010
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Pig (Porcine) Polyclonal Insulin Primary Antibody für IF, IHC - ABIN926149
Johansson, Rasmusson, Niclou, Forslund, Gustavsson, Nilsson, Korsgren, Magnusson: Formation of composite endothelial cell-mesenchymal stem cell islets: a novel approach to promote islet revascularization. in Diabetes 2008
Human Monoclonal Insulin Primary Antibody für IF (p) - ABIN722608
Zöllner, Jouni, Panzer, Khadour, Janzen, Wesche, Ten Berg, Schellong, Heinken, Greinacher, Bakchoul: Platelet activation in the presence of neutral protamine Hagedorn insulin: a new feature of antibodies against protamine/heparin complexes. in Journal of thrombosis and haemostasis : JTH 2016
Cow (Bovine) Monoclonal Insulin Primary Antibody für ELISA - ABIN2475102
Oran, Jarvis, Borges, Sherma, Nelson: Mass spectrometric immunoassay of intact insulin and related variants for population proteomics studies. in Proteomics. Clinical applications 2011
Mouse (Murine) Polyclonal Insulin Primary Antibody für IHC (fro), IHC (p) - ABIN2475101
Ortsäter, Grankvist, Wolfram, Kuehn, Sjöholm: Diet supplementation with green tea extract epigallocatechin gallate prevents progression to glucose intolerance in db/db mice. in Nutrition & metabolism 2012
genetic association studies in population of children in Japan: Data suggest that mutations in INS, HNF1A (zeige HNF1A Antikörper), HNF4A (zeige HNF4A Antikörper), and HNF1B (zeige HNF1B Antikörper) likely play critical roles in children with insulin-requiring autoantibody-negative type 1 diabetes in the population studied. (INS = insulin; HNF1A (zeige HNF1A Antikörper) = HNF1 homeobox A (zeige HNF1A Antikörper); HNF4A (zeige HNF4A Antikörper) = hepatocyte nuclear factor 4 alpha (zeige HNF4A Antikörper); HNF1B (zeige HNF1B Antikörper) = HNF1 homeobox B (zeige HNF1B Antikörper))
Insulin signaling pathway protects neuronal cell lines by Sirt3 (zeige SIRT3 Antikörper) mediated IRS2 (zeige IRS2 Antikörper) activation.
Insulin promotes progression of colon cancer by upregulation of ACAT1 (zeige ACAT1 Antikörper).
Data suggest that serum leptin (zeige LEP Antikörper) and insulin levels are associated with retinal microvasculature parameters in healthy children and adolescents; higher cardiometabolic risk factors (high serum leptin (zeige LEP Antikörper), insulin, and insulin resistance) correlate with wider retinal arterioles.
Data, including studies involving single-cell analysis, suggest that insulin-secreting cells exhibit 3 major states regarding unfolded protein response (UPR): (1) low UPR and low insulin gene expression; (2) low UPR and high insulin gene expression; (3) high UPR and low insulin gene expression. The latter state promotes cell proliferation; UPR appears to mediate recovery from ER stress due to high insulin production.
Data confirm that cord blood levels of ghrelin (zeige GHRL Antikörper), leptin (zeige LEP Antikörper), and insulin of term newborns correlate with anthropometric parameters at birth (birth weight, head circumference, etc.).
Glucose-dependent de-SUMOylation of tomosyn1 at K298 releases syntaxin1A (zeige STX1A Antikörper) and controls the amplification of exocytosis in concert with a recently-identified tomosyn1-interacting partner; the Ca(2+)-binding protein (zeige PVALB Antikörper) secretagogin (zeige SCGN Antikörper), which dissociates from tomosyn1 in response to Ca(2 (zeige CA2 Antikörper)+)-raising stimuli and is required for insulin granule trafficking and exocytosis downstream of Ca(2 (zeige CA2 Antikörper)+) influx.
results indicate that higher cerebrospinal fluid insulin levels are related to impairment in cognitive performance and biomarkers of Alzheimer's disease among women and non-carriers of the APOE (zeige APOE Antikörper) varepsilon4 allele
single-particle cryo-electron microscopy reconstructions of the 1:2 (4.3 A) and 1:1 (7.4 A) complexes of the insulin receptor (zeige INSR Antikörper) ECD (zeige SHFM1 Antikörper) dimer with insulin
Data suggest that higher plasma levels of ceramide with saturated fatty acid are associated with higher fasting levels of insulin and insulin resistance; in contrast, higher levels of sphingomyelin with saturated fatty acid are associated with lower fasting insulin and insulin resistance; this study was conduced in American Indians in AZ, OK, SD, and ND.
Study used well-tempered bias exchange metadynamics simulations to determine the equilibrium ensembles of an insulin molecule under amyloidogenic conditions of low pH and high temperature. The folded state of a single insulin molecule was shown to be the most stable, longest-lived state even under amyloidogenic conditions.
The findings are consistent with previous studies that indicate a link between Na,K-ATPase (zeige ATP1A1 Antikörper) activity and SFK signaling.
PTPLAD1 (zeige PTPLAD1 Antikörper) and AMPK (zeige PRKAA1 Antikörper) are rapidly compartmentalized within the plasma membrane (PM) and Golgi/endosome fractions after insulin stimulation and that ATIC (zeige ATIC Antikörper) later accumulates in the Golgi/endosome fraction.
Pdx-1 (zeige PDX1 Antikörper), MafA (zeige MAFA Antikörper) and NeuroD1 (zeige NEUROD1 Antikörper) bind to the A, C and E elements in the insulin promoter and regulate the transcriptional activity of the insulin promoter.
The interplay of the adiponectin system, TNFalpha (zeige TNF Antikörper) and insulin at a transcriptional level and, their effects on the adipogenic transcription factor PPARgamma (zeige PPARG Antikörper), as well as on the activation of main insulin signaling pathways, is reported.
Thermodynamics of insulin unfolding have been quantified by differential scanning calorimetry and thermal unfolding measurements to determine the extent and nature of their stabilization of the insulin hexamer.
Exposing the hydrophobic core of insulin can induce the increase of amyloidogenicity and formation of higher-order polymerized fibrils, which is less toxic to membranes.
Data suggest that a mutation in INS (C94Y) results a transgenic disease model for the investigation of permanent neonatal diabetes.
The results show that modulation of plasma insulin levels by dietary carbohydrates seems possible in anabolic sows, but IGF-I (zeige IGF1 Antikörper) levels are less easily modified.
insulin increased GCLc (zeige GCLC Antikörper) promoter activity, which required a prerequisite increase or decrease in medium glucose
The structural dynamics of insulin hexamer dissociation were studied by the photoinduced temperature jump technique and monitored by time-resolved X-ray scattering. The process of hexamer dissociation was found to involve several transient intermediates, including an expanded hexamer and an unstable tetramer.
Insulin signaling role in skeletal muscle atrophy and autophagy in in transition and postpartum period
Differences between human and bovine insulin kinetics under shear
increased sensitivity to glucose clearance and skeletal muscle insulin signaling during dietary restriction
Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin (zeige LEP Antikörper)-NPY (zeige NPY Antikörper) and insulin signaling pathways.
Raman spectra of amino acids by Density Functional Theory method have been calculated. Experimental Raman spectra of insulin has been done. The simulated Raman spectrum of insulin is obtained from amino acid spectrum.
Contains Binding kinetics for insulin binding
Using synchrotron radiation (SR), the crystal structures of T6 bovine insulin complexed with Ni(2 (zeige VMP1 Antikörper)+) and Cu(2+) were solved to 1.50 and 1.45 A resolution, respectively.
The present study examined the effect of insulin-mediated activation of the mammalian target of rapamycin (zeige FRAP1 Antikörper) complex 1 (MTORC1) signaling network on the proliferation of primary culture of theca-interstitial (T-I) cells.
insulin supports early initiation of the mesodermal factor Brachyury (zeige TBX1 Antikörper) and the signalling molecules Wnt3a (zeige WNT3A Antikörper) and Wnt4 (zeige WNT4 Antikörper) as well as the progression of mesoderm formation
Data show that type 1 diabetic blastocyst did not express insulin mRNA.
High INS2 expression is associated with weight gain and obesity.
Data (including data from studies in knockout mice) suggest that Ins2 is involved in impaired nociception/diabetic neuropathy; here, mice heterozygous for mutant Ins2 exhibit (a) significant loss of intra-epidermal nerve fibers, (b) markedly reduced responsiveness to heat in dorsal root ganglion neurons, and (c) mostly unchanged function of cold-sensitive neurons; such mice become diabetic soon after weaning.
In the present study, the mRNA expression of the two mouse insulin genes Ins1 and Ins2 was investigated in MIN6 cells treated with different concentrations of melatonin, and insulin secretion was detected under the same conditions. Following the overexpression or silencing of MTNR1B (zeige MTNR1B Antikörper), the activities of components of the MAPK (zeige MAPK1 Antikörper) signaling pathway
These results suggest that PABP (zeige EBP Antikörper) interacts with HuD (zeige ELAVL4 Antikörper) in basal glucose conditions making translation inhibitory complex, however upon glucose stimulation this association is affected and PABP (zeige EBP Antikörper) is acted upon by PDI (zeige PDIA3 Antikörper) resulting in stimulation of insulin translation.
Data (including data from studies using knockout mice) suggest that Ins1 and Ins2 are required for pancreatic beta-cell maturation; thus, Ins1 and Ins2 are needed for normal beta-cell development and for maintenance of normal beta-cell function.
cTAGE5 (zeige CTAGE5 zeige) deletion in pancreatic beta cells impairs proinsulin trafficking and insulin biogenesis in mice.
These results suggest that prolonged exposure to hyperglycemia in the Ins2(Akita+/-) mice leads to progressive testicular disruption mediated by testicular activin (zeige Actbeta Antikörper) activity, rather than hormonal dysregulation.
report that EndMTs occur in the diabetic endothelium of Ins2Akita/wt mouse, and show that induction of sex determining region Y-box 2 (Sox2 (zeige SOX2 Antikörper)) is a mediator of excess BMP signaling that results in activation of EndMTs and increased vascular calcification
Transplantation of transduced hematopoietic stem cells (HSCs) expressing proinsulin II prevents diabetes development.
Wnt3a increased the expression of NeuroD1 and Ins2 in the hypothalamus.
Temporal and spatial expression of two insulin genes (insa and insab) during early developmental stages.
These findings suggest that GHRL (zeige GHRL Antikörper) regulates INS synthesis by mediating its action on growth hormone secretagogue-receptor (zeige GHSR Antikörper) in the central nervous system and partly involved in carbohydrate-glycogen (zeige GYS2 Antikörper) metabolism.
Our results indicate that in adult tilapia insulin expression is not restricted to the endocrine pancreatic cells, but also occurs in endocrine cells of the pituitary gland and in the neuronal cells of the brain.
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.