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anti-Human IL1RN Antikörper:
anti-Mouse (Murine) IL1RN Antikörper:
anti-Rat (Rattus) IL1RN Antikörper:
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Human Polyclonal IL1RN Primary Antibody für ICC, IF - ABIN442533
Køllgaard, Enevold, Bendtzen, Hansen, Givskov, Holmstrup, Nielsen: Cholesterol crystals enhance TLR2- and TLR4-mediated pro-inflammatory cytokine responses of monocytes to the proatherogenic oral bacterium Porphyromonas gingivalis. in PLoS ONE 2017
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Human Monoclonal IL1RN Primary Antibody für IA, IHC (fro) - ABIN2191920
Muzio, Polentarutti, Sironi, Poli, De Gioia, Introna, Mantovani, Colotta: Cloning and characterization of a new isoform of the interleukin 1 receptor antagonist. in The Journal of experimental medicine 1995
Show all 2 Pubmed References
Human Polyclonal IL1RN Primary Antibody für FACS, IF - ABIN1882098
Kumar, Kumar, Dixit: Evidences showing association of interleukin-1B polymorphisms with increased risk of gastric cancer in an Indian population. in Biochemical and biophysical research communications 2009
Mouse (Murine) Polyclonal IL1RN Primary Antibody für ELISA, WB - ABIN5518924
Lu, Jiang, Cao, Zhang, Zhang, Ji, Gao: TRAF6 upregulation in spinal astrocytes maintains neuropathic pain by integrating TNF-α and IL-1β signaling. in Pain 2015
Study findings suggest that both promoter and exon polymorphisms of IL-1B (zeige IL1B Antikörper) gene have a significant role in the risk of developing Graves' disease (GD), whereas IL-1RN-VNTR variant has no association with GD in North India Kashmiri population.
Interleukin 1 receptor antagonist*A2 might be a risk factor for progressive vitiligo (zeige MITF Antikörper).
IL1 (zeige IL1A Antikörper)-Ra is an independent predictor for adverse outcomes in patients with documented coronary artery disease.
Carrying allele IL1RN*2 had a strong association with idiopathic recurrent spontaneous abortion (iRSA) in Mexican women; this polymorphism codifies for a low-function protein, which may allow for increased activity of IL-1 (zeige IL1A Antikörper) pro-inflammatory axis in iRSA.
The single nucleotide polymorphism (SNP) of IL-1beta (zeige IL1B Antikörper) gene (rs3917356G>A) increased the risk of HCC (zeige FAM126A Antikörper) in the recessive model (p<0.001, OR=2.58, 95% CI=1.53-4.33), whereas other SNPs in IL-1alpha and IL-1RA showed no significant association between Hepatocellular carcinoma patients and controls.
there was no sufficient evidence to support the association between IL-1RN 86-bp VNTR polymorphism and ischemic stroke (Meta-Analysis)
This study suggested that -511 C/T (rs16944) and -31 C/T (rs1143627) polymorphisms in IL-1beta gene may not be involved in RPL in Iranian Azeri women. Also the promoter polymorphism of the IL-1RN gene may not play a role in the susceptibility to RPL.
Serum interleukin 1 receptor antagonist (IL1RA) and granzyme B (GZMB) levels were markedly increased in Crohn's disease (CD) patients, suggesting that these markers can serve as biomarkers to identify gut inflammation.
this study reflects the importance of the IL1RN*2/2 genotype and its possible association in the pathogenesis of RA by regulation in the IL-1Ra production.
In Pakistani population, an increased risk of gastric cancer development is associated with the carriage of IL-1B (zeige IL1B Antikörper)-511*T and IL-1RN*2 alleles
This study identified IL-1Ra as an early immunomodulatory mediator that could be involved in the immunopathogenesis of porcine reproductive and respiratory syndrome virus infections.
The variable number of tandem repeats polymorphism in the IL-1RN gene may be a useful predictor of negative symptom improvement in schizophrenic patients treated with antipsychotic drugs.
common variation across the IL-1RN gene is strongly associated with IL-1RA levels.
Expression of IL-1RN in the endometrium is likely regulated by estradiol and progesterone and suggest that IL-1RN regulates the degree of IL-1 (zeige IL1A Antikörper) signal transduction and thereby plays an important role in the establishment of equine pregnancy.
Findings identify a critical role for IL1Ra in maintaining the natural diversity and composition of intestinal microbiota, and suggest a role for TLR4 (zeige TLR4 Antikörper) in mucosal Th17 cell induction associated with the development of autoimmune disease in mice.
Following vasectomy, IL1alpha (zeige IL1A Antikörper), IL1beta (zeige IL1B Antikörper), IL1ra, IL10 (zeige IL10 Antikörper), and TNF-alpha (zeige TNF Antikörper) may mediate immune reaction in whole epididymis, whereas IL6 (zeige IL6 Antikörper) and TGF-beta1 (zeige TGFB1 Antikörper) may mediate regionally different immune response primarily in the lower part of epididymis.
The current study is the first to demonstrate ex vivo airway hyperreactivity caused by systemic maternal inflammation and postnatal hyperoxia, and it reveals further preclinical mechanistic insights into IL-1Ra as a treatment targeting key pathophysiological features of Bronchopulmonary dysplasia.
the suppressed early innate/inflammatory responses instigated by the imbalance between IL-1beta (zeige IL1B Antikörper) and IL-1Ra is an underlying cause for delayed wound healing in the diabetic corneas
we demonstrate that the release of IL1RA in response to genotoxic stress contributes to the immunosuppressive effects of apoptotic cells.
results provide evidence of the key role of IL1RA secreted by MSCs to both control the polarization of macrophages toward a M2 phenotype and inhibit B cell differentiation in vivo.
Allo-transplantation of mesenchymal stem cells reduces Con (zeige KITLG Antikörper) A liver injury by increasing IL10 (zeige IL10 Antikörper) production through an IL1Ra dependent macrophage switch.
results demonstrate that small intestinal eosinophils play a pivotal role in the maintenance of intestinal homeostasis by regulating Th17 cells via production of IL-1Ra.
While both contributing to pathogen clearance, NLRP3 (zeige NLRP3 Antikörper) more than NLRC4 (zeige NLRC4 Antikörper) contributes to deleterious inflammatory responses in cystic fibrosis (zeige S100A8 Antikörper) and correlates with defective NLRC4 (zeige NLRC4 Antikörper)-dependent IL-1Ra production.
IL-1Ra deficiencies might promote early plaque development in 16-week-old apoE (zeige APOE Antikörper)(-/-) mice.
IL-8 (zeige IL8 Antikörper) and IL-1ra showed correlation with the severity of colitis. These observations should significantly further understandings on the role of neutrophils and monocytes in the immunopathogenesis of ulcerative colitis
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
, IL1RN (IL1F3)
, interleukin-1 receptor antagonist protein
, intracellular IL-1 receptor antagonist type II
, intracellular interleukin-1 receptor antagonist (icIL-1ra)
, type II interleukin-1 receptor antagonist
, interleukin 1 receptor antagonist
, interleukin-1 receptor antagonist secretory form
, secretory interleukin-1 receptor antagonist
, IL-1 receptor antagonist