anti-Growth Hormone 1 (GH1) Antikörper

Human Growth Hormone 1 (GH1) Interaktionspartner

1. Homozygous GH1 deletion is associated with growth hormone deficiency.

2. Human Growth Hormone Inhibits CLAUDIN-1 (zeige CLDN7 Antikörper) Expression Through Activation of Signal Transducer and Activator of Transcription 3 (STAT3 (zeige STAT3 Antikörper)).

3. GH1 and GHRHR screening revealed eleven variations in 24 (21%) patients with isolated growth hormone deficiency of which, four were novel deleterious, one novel non-pathogenic and six reported changes.

4. The results suggest that GH regulates energy metabolism directly in myocytes and that UCP2 (zeige UCP2 Antikörper) participates in the signal transduction pathway that functions downstream of the GHR (zeige GHR Antikörper)/JAK (zeige JAK3 Antikörper)/STAT (zeige STAT1 Antikörper).

5. These results implicate TIMP3 (zeige TIMP3 Antikörper) as a modulator of cell surface GHR (zeige GHR Antikörper) abundance and the ability of GH to promote cellular signaling.

6. Children with GH excess underwent medical treatment with lanreotide and a minimum clinical/biochemical follow up of 2 years is reported. The present study demonstrates that GH excess should be considered as a relative frequent endocrine manifestation in NF1 (zeige NF1 Antikörper) patients, similarly to central precocious puberty

7. Thus, GHRH (zeige GHRH Antikörper) analogs of the Miami series powerfully suppress tumor growth, but have only a weak endocrine GH inhibitory activity. The suppression of tumor growth could be induced in part by the downregulation of GHRH (zeige GHRH Antikörper) receptors levels.

8. The intrinsic amyloidogenicity of growth hormone, in the presence of contaminating prion protein (zeige PRNP Antikörper) (and perhaps prolactin (zeige PRL Antikörper) as well) and amyloid-beta contained in some cadavers' pituitaries, may have led to the observed co-occurring of Creutzfeldt-Jakob disease and Alzheimer's disease.

9. To our knowledge, c.-223C>T is the first homozygous point mutation in the GH1 promoter that leads to short stature due to idiopathic growth hormone deficiency.

10. Data show that the recombinant protein produced by the plasmid-free E coli strain was purified and characterized to be human growth hormone (hGH).

Mouse (Murine) Growth Hormone 1 (GH1) Interaktionspartner

1. These results indicate that up-regulation of GH in the lungs of DJ-1 (zeige PARK7 Antikörper) KO mice may enhance the malignancy of B16F10 cells and nodule formation in pulmonary metastasis of melanoma.

2. Confirmation of the impairment of GH-IGF-1 (zeige IGF1 Antikörper) release in hyperphagic MC4R (zeige MC4R Antikörper) KO mice suggests a role for insulin (zeige INS Antikörper) in regulating both the release of GH, but also in mediating growth during periods of physiologically suppressed GH-IGF-1 (zeige IGF1 Antikörper) levels

3. When charged with hypoxia-ischemia, mutant brains with deleted IGF-1 (zeige IGF1 Antikörper) receptor were broadly protected from cell damage, neuroinflammation and cerebral edema.

4. Thiol-disulfide exchange reactions in hGH and related model peptides were influenced by higher order structure, by the size of the thiol reactant and by an Arg residue adjacent to Cys (zeige DNAJC5 Antikörper) in the thiol reactant.

5. Growth hormone deficient mice exhibited renal hypertrophy in tubular epithelial cells.

6. observations demonstrate that germline loss of ghrelin-O-acyltransferase alters Growth Hormone release and patterning

7. alter miR (zeige MLXIP Antikörper)-19b concentrations in hematopoietic stem cells (HSCs) and affect HSC (zeige FUT1 Antikörper) migration

8. Moderate elevations in circulating GH and IGF-I (zeige IGF1 Antikörper) can directly increase basal insulin (zeige INS Antikörper) secretion without impacting beta-cell mass, independent of changes in whole body insulin (zeige INS Antikörper) sensitivity and hyperlipidemia.

9. Acylated ghrelin (zeige GHRL Antikörper) is not required for the surge in pituitary growth hormone observed in pregnant mice.

10. STAT5 (zeige STAT5A Antikörper) signaling is increased in the liver in GH-transgenic mice during the growth period, with a balance between positive and negative effectors resulting in accelerated but controlled growth.

Cow (Bovine) Growth Hormone 1 (GH1) Interaktionspartner

1. bGH mice had increased body weight and decreased percent fat mass. Serum FGF21 (zeige FGF21 Antikörper) levels were significantly elevated in bGH mice. Expression of Fgf21 (zeige FGF21 Antikörper), Fgfr1 (zeige FGFR1 Antikörper), and Klb (zeige KLB Antikörper) mRNA in white AT and liver were downregulated or unchanged in bGH mice.

2. GH/HpaII locus as candidate marker for body weight in cattle rather than MSTN (zeige MSTN Antikörper)/DraI.

3. An SNP GH4.1 in a growth hormone gene was significantly related to a weaning weight.

4. The association of IGF1 (zeige IGF1 Antikörper), GH, and PIT1 (zeige POU1F1 Antikörper) markers with growth and reproductive traits were assessed.

5. The total frequencies for the combined genotypes for the bGH and RORC (zeige RORC Antikörper) genes, which provide for superior meat quality and carcass weight, in the populations of Kazakh white-headed cattle

6. Whereas only moderate structural changes were observed with up-regulation of GH/IGF-I (zeige IGF1 Antikörper) axis, disruption of the GH receptor (zeige GHR Antikörper) had pronounced effects upon tendon ultra-structure.

7. this study identifies a biochemical mechanism for the regulation of SCFAs on bovine GH and PRL (zeige PRL Antikörper) gene transcription in dairy cow anterior pituitary cells

8. homozygote genotypes of GH (LL) and beta-LG (AA) were superior compared to heterozygote genotypes, whereas, the heterozygote genotype of Pit-1 (zeige POU1F1 Antikörper) gene (AB) was desirable

9. one GH1 SNP, GH33, was significantly associated with milk protein (zeige CSN2 Antikörper) yield in the second lactation. Several GH1 SNPs were significantly associated with fertility.

10. GH and IGF-I (zeige IGF1 Antikörper) genotypes had no substantial effect on productive parameters, though IGF-I (zeige IGF1 Antikörper) genotype affected calving-first service interval in primiparous cows. However, the genotypes do alter the endocrine/metabolic profiles of the transition dairy cow.

Pig (Porcine) Growth Hormone 1 (GH1) Interaktionspartner

1. Data indicate that the dual effects of cortistatin (zeige CORT Antikörper) on growth hormone release parallel those of somatostatin (zeige SST Antikörper) and are probably mediated by the same receptor(s) and signaling pathway(s) for both peptides.

2. ghrelin increased growth hormone secretion but not growth hormone synthesis by ovarian follicles

Horse (Equine) Growth Hormone 1 (GH1) Interaktionspartner

1. Plasma levels of growth hormone (as well as glucose, insulin (zeige INS Antikörper), and leptin (zeige LEP Antikörper)) are highly correlated with the duration of winter anovulatory phase.

Guinea Pig Growth Hormone 1 (GH1) Interaktionspartner

1. Expression of PRL (zeige PRL Antikörper) and GH in the guinea pig is prominent in the anterior pituitary, similar to known expression patterns of PRL (zeige PRL Antikörper) and GH for other species.

Zebrafish Growth Hormone 1 (GH1) Interaktionspartner

1. Reproductive tests showed that double transgenic males did not differ from non-transgenics. It is possible that GHR (zeige GHR Antikörper) excess in the muscle tissues of double transgenics may have contributed to lower circulating GH levels and thus reduced the negative effects of this hormone with respect to reproduction.

2. that concomitant overexpression of GH and GHR (zeige GHR Antikörper) resulted in a strong decrease of the somatotrophic axis intracellular signaling by diminishing its principal transcription factor signal transducer and activator of transcription 5.1 (zeige STAT5B Antikörper).

3. Effects of somatotrophic axis (GH/GHR (zeige GHR Antikörper)) double transgenesis on structural and molecular aspects of the zebrafish immune system

4. The zebrafish gh1 mutant, vizzini, exhibits decreased somatic growth, increased adipose tissue accumulation, and disrupted adipose plasticity after nutrient deprivation.

5. tbx5 (zeige TBX5 Antikörper) knockdown causes a pseudo GH deficiency in zebrafish during early embryonic stages, and supplementation of exogenous GH can partially restore dysmorphogenesis, apoptosis, cell growth inhibition, and abnormal cardiomyogenesis

Atlantic Salmon (Salmo salar) Growth Hormone 1 (GH1) Interaktionspartner

1. Findings show similar regulatory growth hormone (GH) and insulin-like growth factor 1 (IGF-1 (zeige IGF1 Antikörper)) responses in both Atlantic salmon and rainbow trout.

Goat Growth Hormone 1 (GH1) Interaktionspartner

Rainbow Trout (Oncorhynchus mykiss) Growth Hormone 1 (GH1) Interaktionspartner

1. Findings show similar regulatory growth hormone (GH) and insulin-like growth factor 1 (IGF-1 (zeige IGF1 Antikörper)) responses in both Atlantic salmon and rainbow trout.