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anti-Human EGFR Antikörper:
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Human Polyclonal EGFR Primary Antibody für IHC, WB - ABIN6713327
Li, Sun, Fang, Han, Luo, Wang, Pan, Hu, Zhang, Pao, Shen, Ji, Chen: Lung adenocarcinomas with HER2-activating mutations are associated with distinct clinical features and HER2/EGFR copy number gains. in Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2012
Show all 10 Pubmed References
Human Polyclonal EGFR Primary Antibody für CyTOF, ELISA (Capture) - ABIN4899925
Sarup, Jin, Turin, Bai, Beryt, Brdlik, Higaki, Jorgensen, Lau, Lindley, Liu, Ni, Rozzelle, Kumari, Watson, Zhang, Shepard: Human epidermal growth factor receptor (HER-1:HER-3) Fc-mediated heterodimer has broad antiproliferative activity in vitro and in human tumor xenografts. in Molecular cancer therapeutics 2008
Show all 8 Pubmed References
Human Polyclonal EGFR Primary Antibody für WB - ABIN3042517
Ge, Yu, Petitte, Zhang: Epidermal growth factor-induced proliferation of chicken primordial germ cells: involvement of calcium/protein kinase C and NFKB1. in Biology of reproduction 2009
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Human Polyclonal EGFR Primary Antibody für IHC - ABIN966041
Buerger, Nagel-Wolfrum, Kunz, Wittig, Butz, Hoppe-Seyler, Groner: Sequence-specific peptide aptamers, interacting with the intracellular domain of the epidermal growth factor receptor, interfere with Stat3 activation and inhibit the growth of tumor cells. in The Journal of biological chemistry 2003
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Human Polyclonal EGFR Primary Antibody für ELISA (Detection), FACS - ABIN4899924
Gonzalez, Seurynck-Servoss, Crowley, Brown, Omenn, Hayes, Zangar: Development and validation of sandwich ELISA microarrays with minimal assay interference. in Journal of proteome research 2008
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Human Polyclonal EGFR Primary Antibody für CyTOF, FACS - ABIN4900628
Weissenbacher, Vrekoussis, Roeder, Makrigiannakis, Mayr, Ditsch, Friese, Jeschke, Dian: Analysis of Epithelial Growth Factor-Receptor (EGFR) Phosphorylation in Uterine Smooth Muscle Tumors: Correlation to Mucin-1 and Galectin-3 Expression. in International journal of molecular sciences 2013
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Human EGFR Primary Antibody für IHC - ABIN966039
Yamamasu, Sato, Ogita, Inoue: Role of glutathione metabolism and apoptosis in the regression of liver hemopoiesis. in Free radical biology & medicine 1997
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Human Polyclonal EGFR Primary Antibody für IHC - ABIN966047
Burnett, Barrow, Cohen, Snyder, Sabatini: RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. in Proceedings of the National Academy of Sciences of the United States of America 1998
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Human Monoclonal EGFR Primary Antibody für IHC (f), ICC - ABIN1027691
Fortunel, Hatzfeld, Rosemary, Ferraris, Monier, Haydont, Longuet, Brethon, Lim, Castiel, Schmidt, Hatzfeld: Long-term expansion of human functional epidermal precursor cells: promotion of extensive amplification by low TGF-beta1 concentrations. in Journal of cell science 2003
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Human Polyclonal EGFR Primary Antibody für WB - ABIN5518909
Salenius, Haapanen, Harju, Jokela, Riekkinen: Late carotid restenosis: aetiologic factors for recurrent carotid artery stenosis during long-term follow-up. in European journal of vascular surgery 1989
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Results indicated that most periocular squamous cell carcinomas of horses expressed epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2).
In segmentation mutants, where specific peaks of EGFR ligands fail to form, gaps in signaling activity appear, leading to coincident hid up-regulation and subsequent cell death. In wild-type embryos, the segmentation cascade elicits the segmental production of several epidermal growth factor receptor (EGFR) ligands, including the transforming growth factor Spitz (TGFalpha), and the neuregulin, Vein.
In this study, whole genome expression analysis was performed to identify genes activated by JAK/STAT and/or EGFR..AdamTS-A mRNA becomes enriched at the anterior and posterior poles of the egg chamber at stages 6 to 7 and is regulated by JAK/STAT.
Wnt signaling functions genetically upstream of EGFR signaling by activating the expression of the EGFR ligand, Spitz.
The somatic EGFR-ERK activity appeared to regulate the termination of Bam expression in the germline and promote subsequent differentiation to the spermatocyte stage.
stress-dependent EGFR/MAPK promotes gut regeneration via a novel mechanism that operates independently of Insulin/Pi3K/TOR signaling.
EGFR/ARF6 regulation of Hh signaling stimulates oncogenic Ras tumor overgrowth in Drosophila.
Graf functions to downregulate EGFR signaling.
Data show that EGFR controls the proper formation of brain neuroblasts by regulating the number, survival and proneural gene expression of neuroectodermal progenitor cells which suggest that EGFR signalling is crucially important for patterning and early neurogenesis of the brain.
The activity of Gro is antagonized by EGFR signaling, which inhibits Gro-dependent repression via p-ERK mediated phosphorylation.
These results reveal that ESCRT-0 (ESCRT-0 components stam and hrs)mutants inhibit EGFR signaling by disrupting Rhomboid endosomal trafficking in the ligand-producing cells.
we find that EGFR regulates the apical determinant Crb and the extracellular matrix regulator Serp, two factors previously known to control tube length. EGFR regulates the organisation of endosomes in which Crb and Serp proteins are loaded
Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr) pathway in the lateral epidermis for sustained dpp expression in the LE. Specifically, we demonstrate that Egfr pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK signaling
Loss of Usp5 results in upregulation of Notch signaling and downregulation of RTK signaling by EGF receptor (EGFR) and Sevenless (Sev), leading to impaired photoreceptor development.
These data demonstrate a strong genetic link between dG9a and the EGFR signaling pathway.
Avermectin directly interacts with EGFR and leads to the activation of the EGFR/AKT/ERK pathway.
The dorsoventral patterning and EGFR signaling genes play essential roles in correct identity determination and differentiation of lateral glia in the Drosophila nervous system.
Data suggest that OSCP1 (organic solute carrier partner 1) plays multiple roles during eye development in D. melanogaster; OSCP1 regulates developmental gene expression and epidermal growth factor receptor signaling pathway in imaginal discs of eye.
The vector of cell movement is regulated by localised epidermal growth factor (EGF) signalling from the distally placed tip cell lineage and the acquisition of planar polarity leads to asymmetric pulsatile Myosin II accumulation.
Our findings provide in vivo evidence for the role of adult neurons in the maintenance of glia and a novel role for EGFR signaling in the autophagic flux.
Gro inhibits rho expression in undifferentiated cells and represses the expression of both ato and rho in non-R8 precursors during initiation of photoreceptor differentiation in an E(spl)-dependent manner.
Combination of an EGFR tyrosine kinase inhibitor and a NF-kappaB inhibitor effectively suppressed cetuximab-resistant HNSCC and interfering with the EGFR-LTbeta interaction reverses resistance.
Study demonstrated that IGF-I can stimulate egfr expression in both follicles cell culture and intact follicles promoting oocyte maturation.
These results indicate that maintenance of Pgrmc1 signaling is required for Egfr expression on zebrafish oocyte cell membranes and for conserving the functions of Egfr in maintaining meiotic arrest through estrogen activation of Gper.
EGFR signaling in vertebrate oocytes can prevent meiotic progression.
the expression of EGFR was mainly restricted to the follicle cells with little expression in the oocytes
The esophageal squamous cell carcinoma patients with the CC genotype of PLCE1 rs17109671 and EGFR rs2072454 have poor overall survival.
interactions of EGFR binding to phosphorylated Mig6-segment2.
We found that both protein and gene expression levels of serum cMET, HGF and EGFR were higher in patients with lung cancer. We suggest that protein and gene expression levels of c-MET in patients with lung cancer will lead to targeted therapies as a new biomarker.
Positive selection of amino acid replacements during somatic mutagenesis of EGFR gene in cancer cells.
EGFR to KLF5 pathway is predictive of patient progression on platinum-based therapy.
Study found that in cervical cancer patient serum and cancer tissues, EGFR is over-expressed. A small group of cervical cancer patients present mutation of EGFR exon 19 and 21, but at relatively lower incidence. Mutation rates were significantly higher in patients with highly differentiated grade, early TNM stage, and those without lymph node or distal metastasis.
The RAS-PI3K interaction is an important signaling node and potential therapeutic target in EGFR-mutant lung cancer.
ALIX is a regulator of both EGFR activity and PD-L1 surface presentation in basal-like breast cancer (BLBC) cells.
COMMD5 participates in long-range endosome transport, including epidermal growth factor receptor (EGFR) recycling, and provides the strength to deform and assist the scission of vesicles into sorting endosomes.
High EGFR expression is associated with Glioma.
Extracellular vesicle-encapsulated EGFR is protected from targeted inhibitors of EGFR and can trigger signaling pathway in recipient cancer cells, promoting proliferation and migration ability in vitro.
the present study suggests that the four ddPCR testing systems could be used for early detection of EGFR mutations in plasma samples, so that patients can better select the targeted drugs according to the EGFR mutation.
Results provide evidence that KRAS and EGFR gene amplifications mediate resistance to the third-generation EGFR TKIs rociletinib and osimertinibin acquired Afatinib-resistant non-small cell lung cancer harboring exon 19 deletion/T790M in EGFR.
High EGFR expression is associated with breast cancer progression.
Our findings reveal a heterogenous pattern of resistance mechanisms to abivertinib which is distinct from that previously reported with osimertinib. EGFR amplification was the most common resistance mechanism in this cohort.
Actin stabilization through the MC1R consisted of ERK1/2 dependent phosphorylation and inactivation of EGFR signaling with stabilization of synaptopodin and stress fibers in podocytes. These results further explain how patients with nephrotic syndrome show responsiveness to MC1R receptor activation by decreasing EGFR signaling
We present comprehensive mutation profiles of a large cohort of osimertinib-resistance lung cancer patients using mainly cfDNA. Besides C797 mutations, novel secondary mutations of EGFR L718 and L792 residues confer osimertinib resistance, both in vitro and in vivo, and are of great clinical and pharmaceutical relevance.
EGFR-mutant lung cancers harbor a spectrum of concurrent alterations that have prognostic and predictive significance. By utilizing paired samples, we identified several novel acquired alterations that may be relevant in mediating resistance, including an activating mutation in MTOR further validated functionally.
In this article, we discuss the nature of EGFR mutation heterogeneity in NSCLC and review recent preclinical and clinical data that have assessed the sensitivity of different mutations to different EGFR tyrosine kinase inhibitors
Our study reveals that different combinations of TP53, EGFR, and STK11 mutations, together with PD-L1 expression by tumor cells, represent robust parameters to identify best responders to PD-1 blockade.
Inhibiting miR-129-5p function and restoring EGFR protein levels in vivo is sufficient to reverse LC-induced defects in cortical NPC self-renewal.
This study demonstrates that IL-17A activates the IL-17R-EGFR axis in Lrig1(+) stem cells linking wound healing to tumorigenesis.
data point to ZBTB20 as a critical regulator of EGFR expression and hepatocyte proliferation in mouse liver regeneration, and may serve as a potential therapeutic target in clinical settings of liver regeneration.
a novel role for SMAD7 as a tumor promoter in skin carcinogenesis where SMAD7 stimulates the DNA repair pathway and EGFR signaling activation.
these results indicate that EGFR plays an important role in NAFLD and is a potential therapeutic target.
Mig6 regulates the production of inflammatory mediators (TNF-alpha, il-1beta) through inhibiting the over activation of EGFR.
results demonstrate that suppression of the IGF-1R/mTOR-pathway by EGFR/ERK/IGFBP-3 signaling is necessary for balanced osteoblast maturation providing a mechanism for the skeletal phenotype observed in EGFR-deficient mice.
Increased blood pressure in mice with selective smooth muscle cell ablation of EMILIN-1 depends on transactivation of EGFR and enhanced myogenic tone.
Osteoglycin negatively regulates cardiac fibrotic remodelling by attenuating myofibroblast proliferation and migration through LPA3-mediated and Rho/ROCK-dependent inhibition of MT1-MMP translocation, MMP2 activation and EGFR transactivation.
Our data show in vivo and ex vivo the necessity of vascular smooth muscle cell -EGFR for angiotensin II-induced structural and functional vascular remodelling
EGFR regulates CCN2 fibrotic signalling in the kidney
NIH3T3 transfected with EGFR-PPARGC1A as well as A431 showed increased cell proliferation activity. With regard to underlying mechanism, EGFR-PPARGC1A protein causes constitutive tyrosine phosphorylation, and induces the phosphorylation of wild-type full-length epidermal growth factor receptor (EGFR) by dimerization.
only tumors expressing both EGFR and c-Fos responded to anti-EGFR therapy
ADAM17 is needed for EGF-R-mediated induction of IL-6 synthesis, which via IL-6 trans-signaling induces beta-catenin-dependent tumorigenesis.
Low EGFR expression is associated with impaired neural stem cell expansion and hypersensitivity leading to epileptic seizures.
G protein-coupled receptor family C group 5 member A (GPRC5A) deficiency contributes to dysregulated proto-oncogene protein c-mdm2 (MDM2) via activated epidermal growth factor receptor (EGFR) signaling, which promotes lung tumor development.
These findings define a novel mechanism that integrates EGFR and Wnt/beta-catenin pathways to coordinate the delicate balance between proliferation and differentiation during development.
The results identify a novel mechanism of TRAF4-mediated EGFR activation and signaling.
Rotational dynamics of the epidermal growth factor receptor.
These results show that EGFR is a co-factor of Transmissible gastroenteritis virus (TGEV), and that it plays a synergistic role with Aminopeptidase N early in TGEV infection.
this study shows that anemonin may ameliorate LPS-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR signaling pathways
Syndecan-4 mediates porcine respiratory and reproductive syndrome virus entry by interacting with EGFR.
These results indicate that cAMP and oocyte-secreted factors cooperate to promote EGF receptor functionality in developing cumulus oocyte complexes, representing a key component of the acquisition of oocyte developmental competence.
patients experiencing gefitinib dose reduction or short-term treatment interruption due to toxicities did not show inferior survival, compared to those receiving full dose of gefitinib in non-small cell lung cancer patients with EGFR mutation
Report EGFR expression in the normal pancreas.
Injury and activation of purinergic receptors and direct activation of EGFR via EGF induce distinct downstream pathways.
Data suggest that the mechanism of hypoxia-induced increased activation of EGFR kinase is mediated by nNOS-derived nitric oxide.
An expressed transition SNP was identified in Meishan and white composite swine breeds.
EGFR, VEGFR and FGFR are expressed in porcine oviduct and endometrium during the time of implantation [review]
the restricted presence of the functional full-size receptor to the epithelial layer indicates a specific role during early embryonic development, whereas truncated EGF-R forms may potentially regulate contractions and blood flow in the oviduct
The phase-related expression of EGF and EGFR in the endothelium of the uterine artery and its branches suggest the modulatory effect of EGF and its receptor on the uterine artery and the region supplying these vessels.
This result suggests that ubiquitination of the kinase-impaired receptor can mediate its internalization by the clathrin pathway.
A linear relationship of EGF/EGFR, PI3-kinase, MAPK and geminal vesicle breakdown, presents a relatively definitive mechanism of EGF-induced meiotic resumption of porcine oocyte.
mRNA expression of EGF receptor
EGFR activation, by PKC signal pathway, participates in FSH-induced porcine oocyte meiotic resumption.
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
Stimulation of bovine oviduct epithelial cell EGFR with EGF (human recombinant EGF) alone or with EGF in postovulatory/follicular phases (not luteal phase) up-regulates phosphorylation of MAPKs; heat blocks effects of EGF on phosphorylation of MAPKs.
Expression of the erbB/HER receptor family in the bovine uterus during the sexual cycle and the relation of this family to serum sex steroids.
Regulation of the sperm EGFR by ouabain leads to initiation of the acrosome reaction.
EGFR may simultaneously activate c-Src and PI3K to amplify the oxytocin signaling to increase the output of PGF(2 alpha) in endometrial epithelial cells.
results indicate that arginase induction depends in part on epidermal growth factor (EGF) receptor activity, and that EGFR inhibitors may attenuate vascular remodeling without affecting nitric oxide release
Data suggest that epidermal growth factor (EGF) and EGF receptors are important paracrine and/or autocrine regulators of spermatogenesis in bovine.
MT1-MMP has a role in signaling events mediating EGFR transactivation
possible cooperative role of the EGF and HGF pathways and indicate that cross-talk between their respective receptors may modulate mammary gland development in the cow
EGFR is stimulated during capacitation via PKA activation. More activation induces the acrosome reaction, which is induced by GPCR via EGFR transactivation by a signaling pathway involving PKA, SRC & metalloproteinase & effectors PI3K, PLC & PKC.
These results show that MMP-2 activates the EGFR and triggers downstream signaling pathways increasing Reactive Oxygen Species formation and promoting vasoconstriction.
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
, Egf receptor
, drosophila epidermal growth factor receptor homologue
, ellipse torpedo
, epidermal growth factor receptor
, faint little ball
, morphological defects 1
, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
, cell growth inhibiting protein 40
, cell proliferation-inducing protein 61
, proto-oncogene c-ErbB-1
, receptor tyrosine-protein kinase erbB-1
, EGFR-related peptide
, Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)
, avian erythroblastic leukemia viral (v-erbB) oncogene homolog
, epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)
, waved 2
, epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
, egf receptor
, receptor tyrosine kinase ErbB1