Pim-3 Oncogene Proteine (PIM3)

Human Pim-3 Oncogene (PIM3) Interaktionspartner

1. show that PIM1 (zeige PIM1 Proteine) contributes to melanoma cell proliferation and tumor growth in vivo; however, the presence of PIM2 (zeige PIM2 Proteine) and PIM3 could also influence the outcome.

2. These results demonstrate the involvement of PIM (zeige PIM1 Proteine) kinases in LIF (zeige LIF Proteine)-induced regulation in different trophoblastic cell lines which may indicate similar functions in primary cells.

3. PIM (zeige PIM1 Proteine) kinases in classical Hodgkin lymphoma exhibit pleiotropic effects, orchestrating tumor immune escape and supporting Reed-Sternberg cell survival.

4. Our study suggests that up-regulation of Pim-3 successfully accelerated Chronic Obstructive Pulmonary Disease development, and aggravated lung damage

5. High PIM3 expression is associated with osteosarcoma.

6. The expression status of Pim-3 mRNA was significantly associated with pathological parameters such as pre-surgery prostate specific antigen, Gleason score, pathological stage, and lymphoid metastasis.

7. Pim-3 expression was inversely correlated with that of miR (zeige MLXIP Proteine)-377.

8. SSRP1 (zeige SSRP1 Proteine)/Ets-1 (zeige ETS1 Proteine)/Pim-3 signalling is tightly associated with the proliferation, apoptosis, autophagy, invasion and clonogenicity of nasopharyngeal carcinoma cells, and blockage of this signalling facilitates chemosensitivity of the cells to docetaxel.

9. Pim-3 expression showed a positive correlation with tumor cell differentiation.

10. Pim-3 has a role in human pancreatic cancer cell survival against radiation

Mouse (Murine) Pim-3 Oncogene (PIM3) Interaktionspartner

1. Loss of PIM3 is associated with abnormal hematopoietic phenotypes.

2. investigation of physiological role of Pim3 in beta-cell function: regulates glucose-stimulated insulin (zeige INS Proteine) secretion; limits ERK (zeige EPHB2 Proteine) signaling; interacts with SOCS6 (zeige SOCS6 Proteine); Pim3 localized to beta-cell; Pim3 knockout mice display increased glucose tolerance

3. Pim-3 has an important role in modulating c-Myc and PGC-1alpha protein levels and cell growth

4. All three Pim (zeige PIM1 Proteine) kinase family members predominantly phosphorylate Bad on Ser112 and in addition are capable of phosphorylating Bad on multiple sites associated with the inhibition of the pro-apoptotic function of Bad in HEK (zeige EPHA3 Proteine)-293 cells

5. Pim-3 kinase has a novel role in the control of self-renewal of embryonic stem cells.

6. Pim-3 is expressed in endothelial cells and promotes vascular tube formation.