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Buffalo (Bubalus) Polyclonal CHGA Primary Antibody für IEM, ICC - ABIN617895
Poulsom, Chinery, Sarraf, Lalani, Stamp, Elia, Wright: Trefoil peptide expression in intestinal adaptation and renewal. in Scandinavian journal of gastroenterology. Supplement 1992
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Buffalo (Bubalus) Polyclonal CHGA Primary Antibody für IEM, ICC - ABIN617896
Beham, Schmid, Fletcher, Auböck, Pickel: Malignant paraganglioma of the uterus. in Virchows Archiv. A, Pathological anatomy and histopathology 1992
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Human Polyclonal CHGA Primary Antibody für ICC, IF - ABIN266232
Polyak, Mach, Porvasnik, Dixon, Conlon, Erger, Acosta, Wright, Campbell-Thompson, Zolotukhin, Wasserfall, Mah: Identification of adeno-associated viral vectors suitable for intestinal gene delivery and modulation of experimental colitis. in American journal of physiology. Gastrointestinal and liver physiology 2012
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Human Polyclonal CHGA Primary Antibody für IF (cc), IF (p) - ABIN669846
Wang, Ahmad, Shah, Sims, Magness, Allbritton: Capture and 3D culture of colonic crypts and colonoids in a microarray platform. in Lab on a chip 2013
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Human Monoclonal CHGA Primary Antibody für BI, IF - ABIN2689472
Kroon, Martinson, Kadoya, Bang, Kelly, Eliazer, Young, Richardson, Smart, Cunningham, Agulnick, DAmour, Carpenter, Baetge: Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. in Nature biotechnology 2008
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Monoclonal CHGA Primary Antibody für IHC (fro), IHC (p) - ABIN335308
Lloyd, Wilson: Specific endocrine tissue marker defined by a monoclonal antibody. in Science (New York, N.Y.) 1983
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Human Polyclonal CHGA Primary Antibody für IHC, IHC (p) - ABIN4298354
Marbiah, Harvey, West, Louzolo, Banerjee, Alden, Grigoriadis, Hummerich, Kan, Cai, Bloom, Jat, Collinge, Klöhn: Identification of a gene regulatory network associated with prion replication. in The EMBO journal 2014
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Human Monoclonal CHGA Primary Antibody für ICC, FACS - ABIN1724755
El Ali, Fichna, Piniewska, Kosowicz, Grzymis?awski: Chromogranin A as a useful neuroendocrine marker in patients with autoimmune Addison's disease. in Journal of endocrinological investigation 2010
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Human Monoclonal CHGA Primary Antibody für ELISA, WB - ABIN1724756
Mergler, Skrzypski, Sassek, Pietrzak, Pucci, Wiedenmann, Strowski: Thermo-sensitive transient receptor potential vanilloid channel-1 regulates intracellular calcium and triggers chromogranin A secretion in pancreatic neuroendocrine BON-1 tumor cells. in Cellular signalling 2011
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Human Monoclonal CHGA Primary Antibody für ELISA, FACS - ABIN4298360
Sampedro-Núñez, Luque, Ramos-Levi, Gahete, Serrano-Somavilla, Villa-Osaba, Adrados, Ibáñez-Costa, Martín-Pérez, Culler, Marazuela, Castaño: Presence of sst5TMD4, a truncated splice variant of the somatostatin receptor subtype 5, is associated to features of increased aggressiveness in pancreatic neuroendocrine tumors. in Oncotarget 2016
Study indicates that chga may play an important role in nervous system development during the early embryonic stages.
Systemic CST (zeige CORT Antikörper) knockout (CST (zeige CORT Antikörper)-KO) mice on normal chow diet (NCD) ate more food, gained weight, and displayed elevated blood glucose and insulin (zeige INS Antikörper) levels.
CgA (zeige CGA Antikörper) is an important regulator for coordination of mitochondrial dynamics, secretory vesicular quanta and glucose-stimulated insulin (zeige INS Antikörper) secretion for optimal secretory functioning of beta-cells, suggesting a strong, CgA (zeige CGA Antikörper)-dependent positive link between mitochondrial fusion and glucose-stimulated insulin (zeige INS Antikörper) secretion
Increased myocardial CgA (zeige CGA Antikörper) glycosylation and impaired CgA (zeige CGA Antikörper) processing to catestatin in heart failure be considered detrimental because CST (zeige CORT Antikörper) reduces diastolic Ca2 (zeige CA2 Antikörper)+ leak via direct CaMKIIdelta inhibition.
performance of CgA (zeige CGA Antikörper)-deficient Chga-KO mice in treadmill exercise was impaired. CgA (zeige CGA Antikörper) deficiency renders the muscle energy deficient, impairs performance in treadmill exercise and prevents regeneration after exercise-induced tissue damage.
dilated mitochondrial cristae, endoplasmic reticulum and Golgi complex, as well as increased synaptic mitochondria, synaptic vesicles and glycogen (zeige GYS1 Antikörper) granules in Chga-knockout mice compared to WT mice.
the presence of ChgA and subsequent activation of ChgA-reactive T cells are essential for the initiation and development of autoimmune diabetes in NOD mice.
Studied leptin (zeige LEP Antikörper) and CST (zeige CORT Antikörper) modulation of SGLT1 (zeige SLC5A1 Antikörper) expression in hyperleptinemic type 2 diabetic mice.
N-terminal additions to the WE14 peptide of chromogranin A create strong autoantigen agonists in type 1 diabetes.
Data indicate that T-cell receptors that react to chromogranin A (ChgA) and islet amyloid polypeptide (zeige IAPP Antikörper) precursor (IAPP (zeige IAPP Antikörper)) autoantigens were impaired when the thymic stromal cells lacked thymus-specific serine protease (TSSP (zeige PRSS16 Antikörper)).
the important roles of CgA and CgB in glucose and cardiovascular homeostasis. This study also unveils the existence of direct implications of Cgs in the control of behaviour and mood.
Results suggest that severe atopic dermatitis is associated with higher stress levels. Simple salivary CgA (zeige CGA Antikörper) measurements may be useful as an objective assessment of patient stress.
cardiac atria express but do not secrete CgA (zeige CGA Antikörper) into circulation in patients with atrial disease
These results suggest that circulating full-length CgA (zeige CGA Antikörper) is an important inhibitor of angiogenesis and tumor growth, and that cleavage of its C-terminal region markedly reduces its activity. Pathophysiological changes in CgA (zeige CGA Antikörper) blood levels and/or its fragmentation might regulate disease progression in cancer patients.
Results show that chronic lymphocytic leukemia (CLL) patients had increased plasma levels of chromogranin A (CgA), compared to normal subjects, particularly those >70-year-old or those treated with proton pump inhibitors.
The authors show that CHGA-415 T/C polymorphism is an independent risk factor of poor prognosis in critically ill patients
Concurrent increases in plasma BNP (B-type natriuretic peptide (zeige BNP Antikörper)) and CST (zeige GAL3ST1 Antikörper) levels predicted the highest risk for both all-cause and cardiac deaths in chronic heart failure patients.
Full-length CgA (zeige CGA Antikörper) is an independent indicator of atherosclerotic plaques in carotid artery stenosis.
Even a single baseline measurement of CgA (zeige CGA Antikörper) can be useful in establishing prognosis in this group, if this parameter exceeds its upper normal limit more than tenfold.
Compared with chromogranin A, chromogranin B (zeige CHGB Antikörper) may be more useful during proton pump inhibitor treatment and can detect tumors without liver metastases.
Salivary impairments and high levels of CHGA are associated with T2DM patients. In addition, CGHA polymorphisms might be associated with salivary gland hypofunction and higher salivary CHGA production in T2DM patients. This could be a significant insight to establish a role for salivary CHGA as a potential clinical biomarker to T2DM.
High pancreastatin levels are significantly associated with neuroendocrine tumors.
No circadian pattern was detected for salivary CgA in either spring or autumn, and there were no significant effects of gender or age. However, mean salivary CgA concentrations were significantly higher in the pigs sampled in autumn, compared to spring.
expression and localization of chromogranin A (CgA), chromogranin B (CgB (zeige CHGB Antikörper)), synaptophysin (zeige SYP Antikörper), and insulin (zeige INS Antikörper) were ultrastructurally studied with the immunogold technique in porcine and human pancreatic islet neuroendocrine cells
Vasoconstriction-Inhibiting Factor (VIF (zeige BTG1 Antikörper)), a degradation product of chromogranin A, is a vasoregulatory peptide that modulates the vasoconstrictive effects of angiotensin II by acting on the angiotensin II type 2 receptor (zeige AGTR2 Antikörper).
chromogranin A has a role in the IP(3)-mediated Ca(2 (zeige CA2 Antikörper)+) release mechanism of secretory granules
chromogranin A has a specific site in the N-terminal domain that can bind membrane lipids from different species
role of coupling with the inositol 1,4,5-trisphosphate receptor/Ca2 (zeige CA2 Antikörper)+ channel (InsP3R (zeige ITPR1 Antikörper))in the Ca2 (zeige CA2 Antikörper)+-dependent ciliary movement
involvement of CGA (zeige CGA Antikörper) with other components of the senile plaque
significant species differences in vasoactivity of the N-terminal domain of ChgA
determination of the subcellular distribution of chromogranins A and B in chromaffin cells; results suggest that chromogranins are at the center of intracellular Ca(2 (zeige CA2 Antikörper)+) homeostasis in secretory cells
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides\; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown.
, chromogranin A
, betagranin (N-terminal fragment of chromogranin A)
, parathyroid secretory protein 1
, pituitary secretory protein I