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Data suggest that RGS16 functions as a GAP (GTPase (zeige RACGAP1 Proteine) accelerating protein) in the SCN (zeige SRI Proteine) (suprachiasmatic nucleus) and is required for circadian timing. [REVIEW]
The data establish miR (zeige MLXIP Proteine)-181a as an oncomiR that promotes chondrosarcoma progression through a new mechanism involving enhancement of CXCR4 (zeige CXCR4 Proteine) signaling by inhibition of RGS16.
suggest that deltaEF1 family proteins promote cell motility of breast cancer cells directly or indirectly through repressing expression of RGS16
these results indicate that RGS16 restricts the activation-induced pro-inflammatory profile in myeloid cells.
Data indicate that multiplex ligation-dependent probe amplification (MLPA) probes (Fig. 2) corresponding to the RGSL2, RGSL1 and RGS16 genes showed 64.5 % tumour samples with copy number gains and 5 % tumour samples with copy number losses.
cotreatment with RGS16 siRNA reversed the downregulation of nuclear factor-kappaB expression induced by combined inhibition of LSD1 (zeige KDM1A Proteine) and HDACs, suggesting a crucial role of RGS16 in controlling key pathways of cell death in response to combination therapy.
Missense mutations in RGS16 gene is associated with breast cancer.
RGS16 and FosB (zeige FOSB Proteine) are underexpressed in pancreatic cancer with lymph node metastasis and associated with reduced survival
Increased RGS16 levels are associated with colorectal cancer.
Src (zeige SRC Proteine) mediates RGS16 tyrosine phosphorylation, which may promote RGS16 stability.
This study reveals how RGS (zeige PITX2 Proteine) proteins modulate Galphai2 (zeige GNAI2 Proteine) signaling to facilitate thymocyte egress and T cell trafficking.
Findings indicate that regulator of G-protein signaling 16 (RGS16) plays an important role in platelet function by modulating CXCL12 (zeige CXCL12 Proteine)-dependent platelet activation.
RGS16-mediated confinement of T cells to Schistosome granulomas mitigates widespread cytokine-mediated pulmonary inflammation.
Gene ablation of Rgs16 leads to the loss of circadian production of cAMP and as a result lengthens circadian period of behavioural rhythm.
RGS16 provides a signaling mechanism for glucose production to inhibit GPCR-stimulated fatty acid oxidation in hepatocytes
The present study suggests that liver and/or thalamus regulate the food-entrained circadian behavior through G protein-mediated signal transduction pathway(s).
Rgs16 and Rgs8 (zeige RGS8 Proteine) are likely to control aspects of islet progenitor cell activation, differentiation and beta-cell expansion in embryos and metabolically stressed adults.
Data show that knockdown of TNFR (zeige TNFRSF1A Proteine)-associated factor 6 or NF-kappaB (zeige NFKB1 Proteine) activator 1 in 70Z/3 pre-B cells led to decreased Rgs16 expression, indicating that both of these two genes are involved in IL-17 (zeige IL17A Proteine)-mediated activation of NF-kappaB (zeige NFKB1 Proteine) signaling in B cells.
results suggest that the amino-terminal palmitoylation of regulator of G-protein signaling 16 protein(RGS16) promotes its lipid raft targeting that allows palmitoylation of a poorly accessible cysteine residue
RGS16 expression in T lymphocytes results in selective blockade of T cell migration to certain chemokines and enhancement of T cell cytokine synthesis in response to a complex inflammatory stimulus.
Facilitated degradation of the RGS16 by porcine circovirus type 2 ORF3 further enhances NFkappaB translocation into the nucleus through the ERK1/2 signalling pathway and increased IL-6 (zeige IL6 Proteine) and IL-8 (zeige IL8 Proteine) mRNA transcripts.
The role of RGS16 in porcine circovirus infections via its binding with a nonstructural protein encoded by open reading frame 3 is reported.
The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade.
, regulator of G-protein signalling 16
, retinal-specific RGS
, retinally abundant regulator of G-protein signaling
, regulator of G-protein signaling 16
, regulators of G protein signaling XRGSI
, Regulator of G-protein signaling 16