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Data suggest that RGS16 functions as a GAP (GTPase accelerating protein) in the SCN (suprachiasmatic nucleus) and is required for circadian timing. [REVIEW]
The data establish miR-181a as an oncomiR that promotes chondrosarcoma progression through a new mechanism involving enhancement of CXCR4 signaling by inhibition of RGS16.
suggest that deltaEF1 family proteins promote cell motility of breast cancer cells directly or indirectly through repressing expression of RGS16
these results indicate that RGS16 restricts the activation-induced pro-inflammatory profile in myeloid cells.
Data indicate that multiplex ligation-dependent probe amplification (MLPA) probes (Fig. 2) corresponding to the RGSL2, RGSL1 and RGS16 genes showed 64.5 % tumour samples with copy number gains and 5 % tumour samples with copy number losses.
cotreatment with RGS16 siRNA reversed the downregulation of nuclear factor-kappaB expression induced by combined inhibition of LSD1 and HDACs, suggesting a crucial role of RGS16 in controlling key pathways of cell death in response to combination therapy.
Missense mutations in RGS16 gene is associated with breast cancer.
RGS16 and FosB are underexpressed in pancreatic cancer with lymph node metastasis and associated with reduced survival
Increased RGS16 levels are associated with colorectal cancer.
Src mediates RGS16 tyrosine phosphorylation, which may promote RGS16 stability.
results suggest that palmitoylation of a Cys residue in the regulator of G protein signaling(RGS) box is critical for RGS16 and RGS4 GAPase activating protein activity and their ability to regulate G protein signaling in mammalian cells
results suggest that the amino-terminal palmitoylation of regulator of G-protein signaling 16 protein(RGS16) promotes its lipid raft targeting that allows palmitoylation of a poorly accessible cysteine residue
RGS16 inhibits G alpha 13-mediated, RhoA-dependent reversal of stellation and Serum Response Element activation, thus regulating G alpha 13-mediated signal transduction independently of the RGS box.
RGS16 is a negative regulator of SDF-1-CXCR4 signaling in megakaryocytes
G alpha(i2) is specifically localized in human Fallopian tube epithelial cells, particularly in cilia, & is likely to have cilia-specific role in reproduction.
B4GALT3, DAP3, RGS16, TMEM183A and UCK2--were significantly overexpressed in dup(1q)-positive ALLs compared with high hyperdiploid ALLs without dup(1q).
Regulator of G Signaling 16 has a role in the distinct endoplasmic reticulum stress state associated with aggregated mutant alpha1-antitrypsin Z in the classical form of alpha1-antitrypsin deficiency
The promoter region of RGS16 was found to be methylated in 10% human breast carcinomas
the loss of RGS16 in some breast tumors enhances PI3K signaling elicited by growth factors and thereby promotes proliferation and TKI evasion downstream of HER activation
Facilitated degradation of the RGS16 by porcine circovirus type 2 ORF3 further enhances NFkappaB translocation into the nucleus through the ERK1/2 signalling pathway and increased IL-6 and IL-8 mRNA transcripts.
The role of RGS16 in porcine circovirus infections via its binding with a nonstructural protein encoded by open reading frame 3 is reported.
The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade.
, regulator of G-protein signalling 16
, retinal-specific RGS
, retinally abundant regulator of G-protein signaling
, regulator of G-protein signaling 16
, regulators of G protein signaling XRGSI
, Regulator of G-protein signaling 16