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Mutations in TAX1BP3 cause dilated cardiomyopathy with septo-optic dysplasia
ARHGEF7 (zeige ARHGEF7 Proteine), a guanine nucleotide exchange factor (zeige RASGRF1 Proteine) for Rho GTPases, as one novel TIP-1-interacting protein in human glioblastoma cells
this study reports the identification of two new hGIP-interacting partners, DTX1 (zeige DTX1 Proteine) and STAU1 (zeige STAU1 Proteine).
The study provided the first evidence showing that TIP-1 modulates p53 (zeige TP53 Proteine) protein stability and is involved in the radioresistance of malignant gliomas.
The study reports the identification of 18 new glutaminase (zeige GLS Proteine)-interacting protein - binding peptides with novel internal motifs that map to a number of candidate human glutaminase (zeige GLS Proteine)-interacting protein partner proteins.
this study revealed a novel oncogenic function of TIP-1 suggesting that TIP-1 holds potential as a prognostic biomarker and a therapeutic target in the treatment of human invasive breast cancers.
HPV16 E6, Tip-1 and ARHGEF16 (zeige ARHGEF16 Proteine) may cooperate to activate Cdc42 (zeige CDC42 Proteine) and support a potential link between the expression of HPV16 E6 and Cdc42 (zeige CDC42 Proteine) activation.
This is the first study reporting BAI2 as an interaction partner of GIP (zeige GIP Proteine).
TIP-1 may represent a novel regulatory element in the Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling pathway
HPV16 E6 protein may increase cell motility by augmenting GTP (zeige AK3 Proteine) RhoA (zeige RHOA Proteine) mediated activation of RhoA (zeige RHOA Proteine) kinases and that this is dependent on the expression of the Tip-1 protein
observations indicate a role for TIP-1 in gastrulation movements and in filopodia growth induction
May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.
Tax interaction protein 1
, glutaminase-interacting protein 3
, tax-interacting protein 1
, tax1-binding protein 3
, Tax1 (human T-cell leukemia virus type I) binding protein 3
, Tax1 binding protein 3
, tax interaction protein 1