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This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.
, carboxylesterase 3 (brain)
, esterase 31
, liver carboxylesterase 31 homolog
, FAEE synthase
, carboxyesterase ES-10
, carboxylesterase 3
, fatty acid ethyl ester synthase
, liver carboxylesterase 10
, pI 6.1 esterase
, Es-male carboxylesterase
, liver carboxylesterase 31