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CCT (zeige FLVCR2 Proteine) actively promotes the formation of conformationally different aggregates of gamma-tubulin, a non-amyloidogenic CCT (zeige FLVCR2 Proteine) client protein, which are mediated by specific CCT-gamma (zeige CCT3 Proteine)-tubulin interactions.
that in the face of predominant gamma-tubulin-1 expression, the accumulation of gamma-tubulin-2 (zeige TUBG2 Proteine) in mature neurons and neuroblastoma (zeige ARHGEF16 Proteine) cells during oxidative stress may denote a prosurvival role of gamma-tubulin-2 (zeige TUBG2 Proteine) in neurons
All GCPs are incorporated into the helix via lateral interactions between their N-terminal domains, whereas the C-terminal domains mediate longitudinal interactions with gamma-tubulin.
While binding to gamma-tubulin may help target APC (zeige APC Proteine) to the site of microtubule nucleation complexes, additional C-terminal sequences of APC (zeige APC Proteine) are required to stimulate and stabilize microtubule growth.
a causative link between altered function of AURKA-HMMR-TPX2-TUBG1 and breast carcinogenesis in BRCA1/2 mutation carriers
Results show that CUL4A (zeige CUL4A Proteine)- and CUL4B (zeige CUL4B Proteine)-mediated polyubiquitination of gamma-tubulin for its degradation.
In this study, the molecular basis of interaction between two lateral gamma-tubulin units within the gamma-tubulin ring complex were elucidated by making extensive use of molecular mechanics and molecular dynamics techniques.
Gamma tubulin expression was associated with patients' age, astrocytoma grade, respectability, patient survival and performance. These factors may be important prognostic indicators for patients with astrocytomas.
Recombinant gamma-tubulin can be phosphorylated by Cdk1 (zeige CDK1 Proteine)-cyclin B or Brsk1 (zeige BRSK1 Proteine) and dephosphorylated by Ppp4c (zeige PPP4C Proteine)-R2-R3A in vitro.
Nek9 (zeige NEK9 Proteine) phosphorylates NEDD1 (zeige NEDD1 Proteine) on Ser377 driving its recruitment and thereby that of gamma-tubulin to the centrosome in mitotic cells.
MPK6 (zeige MAPK6 Proteine) phosphorylates EB1c, but not EB1a, and has a role in maintaining regular planes of cell division under stress conditions.
Data show that depletion of either gamma-tubulin or XMAP215 was partially rescued by adding back XMAP215, but not by adding any of the other factors.
Authors report that the only viral nonstructural protein able to reproduce the loss of gamma-tubulin from the microtubule organizing center and the loss of integrity of the microtubule system is Foot-and-mouth disease virus 3C(pro).
Fodrin is a regulatory transporter of gamma-tubulin to the centrosomes for normal progression of mitosis.
Data suggest that localization of Tubg1 (and Plk1 [polo-like kinase 1]) to spindle poles during oocyte meiotic maturation/oogenesis (metaphase I/II) requires participation of Uchl5ip/Haus7 (HAUS augmin-like complex subunit 7 (zeige HAUS7 Proteine)).
a direct interaction with NEDD1 (zeige NEDD1 Proteine) regulates gamma-tubulin recruitment to the centrosome
Gamma-tubulin is a key regulator of asymmetric cytokinesis in mouse oocytes.
pPKCdelta(Thr505) interacts with MTOC-associated proteins pericentrin and gamma-tubulin, and plays a role in meiotic spindle organization in oocytes
Results suggest that Fyn (zeige FYN Proteine) and PI3K might take part in the modulation of membrane-associated gamma-tubulin activities.
SADB (zeige BRSK1 Proteine) kinase activity controls centrosome homeostasis by regulating phosphorylation of gamma-tubulin.
This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is found on chromosome 7.
, gamma-tubulin complex component 1
, tubulin gamma-1 chain
, tubulin, gamma polypeptide
, Tubulin gamma-3 chain
, gamma tubulin