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Four novel heterozygous variants in TUBG1 were identified in patients with malformations of cortical development.
induced FBXL13 expression downregulates centrosomal gamma-tubulin and disrupts centrosomal microtubule arrays. In addition, depletion of FBXL13 induces high levels of CEP192 and gamma-tubulin at the centrosomes with the consequence of defects in cell motility.
CCT actively promotes the formation of conformationally different aggregates of gamma-tubulin, a non-amyloidogenic CCT client protein, which are mediated by specific CCT-gamma-tubulin interactions.
that in the face of predominant gamma-tubulin-1 expression, the accumulation of gamma-tubulin-2 in mature neurons and neuroblastoma cells during oxidative stress may denote a prosurvival role of gamma-tubulin-2 in neurons
All GCPs are incorporated into the helix via lateral interactions between their N-terminal domains, whereas the C-terminal domains mediate longitudinal interactions with gamma-tubulin.
While binding to gamma-tubulin may help target APC to the site of microtubule nucleation complexes, additional C-terminal sequences of APC are required to stimulate and stabilize microtubule growth.
a causative link between altered function of AURKA-HMMR-TPX2-TUBG1 and breast carcinogenesis in BRCA1/2 mutation carriers
Results show that CUL4A- and CUL4B-mediated polyubiquitination of gamma-tubulin for its degradation.
In this study, the molecular basis of interaction between two lateral gamma-tubulin units within the gamma-tubulin ring complex were elucidated by making extensive use of molecular mechanics and molecular dynamics techniques.
Gamma tubulin expression was associated with patients' age, astrocytoma grade, respectability, patient survival and performance. These factors may be important prognostic indicators for patients with astrocytomas.
Recombinant gamma-tubulin can be phosphorylated by Cdk1-cyclin B or Brsk1 and dephosphorylated by Ppp4c-R2-R3A in vitro.
Nek9 phosphorylates NEDD1 on Ser377 driving its recruitment and thereby that of gamma-tubulin to the centrosome in mitotic cells.
Our results reveal for the first time an increased expression of TUBG1 and TUBG2 in lung cancer
overexpression of Cdk1 or BRCA1 greatly expands the gamma-tubulin coating of microtubules, suggesting that the microtubule-bound gamma-tubulin is involved in DNA damage response.
in transformed as well as in non-transformed interphase mammalian cells gamma-tubulin is present not only in cytoplasm but also in nuclei and nucleoli where it can be translocated during mitosis
These results thus report for the first time the identification of Cep70 as an important centrosomal protein that interacts with gamma-tubulin and underscore its critical role in the regulation of mitotic spindle assembly.
The data presented here indicate that gamma-tubulin has a profound relationship with actin filament dynamics
a direct interaction with NEDD1 regulates gamma-tubulin recruitment to the centrosome
the 2.7-A crystal structure of human gamma-tubulin bound to GTP-gammaS (a non-hydrolysable GTP analogue)
analysis of human ninein isoforms that are regulated by centrosomal targeting signals and bind to gamma-tubulin
MPK6 phosphorylates EB1c, but not EB1a, and has a role in maintaining regular planes of cell division under stress conditions.
Data show that depletion of either gamma-tubulin or XMAP215 was partially rescued by adding back XMAP215, but not by adding any of the other factors.
Authors report that the only viral nonstructural protein able to reproduce the loss of gamma-tubulin from the microtubule organizing center and the loss of integrity of the microtubule system is Foot-and-mouth disease virus 3C(pro).
Fodrin is a regulatory transporter of gamma-tubulin to the centrosomes for normal progression of mitosis.
Data suggest that localization of Tubg1 (and Plk1 [polo-like kinase 1]) to spindle poles during oocyte meiotic maturation/oogenesis (metaphase I/II) requires participation of Uchl5ip/Haus7 (HAUS augmin-like complex subunit 7).
Gamma-tubulin is a key regulator of asymmetric cytokinesis in mouse oocytes.
pPKCdelta(Thr505) interacts with MTOC-associated proteins pericentrin and gamma-tubulin, and plays a role in meiotic spindle organization in oocytes
Results suggest that Fyn and PI3K might take part in the modulation of membrane-associated gamma-tubulin activities.
SADB kinase activity controls centrosome homeostasis by regulating phosphorylation of gamma-tubulin.
This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is found on chromosome 7.
, gamma-tubulin complex component 1
, tubulin gamma-1 chain
, tubulin, gamma polypeptide
, Tubulin gamma-3 chain
, gamma tubulin