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Human TUBB3 Protein expressed in HEK-293 Cells - ABIN2734576
Qu, Dwyer, Shao, Yang, Huang, Liu: Direct binding of TUBB3 with DCC couples netrin-1 signaling to intracellular microtubule dynamics in axon outgrowth and guidance. in Journal of cell science 2013
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Results demonstrated that TUBB3 mutations impair the interaction of DCC (zeige DCC Proteine) with polymerized TUBB3 in MTs (zeige TIMM8A Proteine) and inhibit netrin-1 (zeige NTN1 Proteine)-induced neurite outgrowth, branching and attraction. These results suggest a disease mechanism underlying TUBB3 mutation-associated axon guidance defects: mutations in TUBB3 disrupt engagement of netrin/DCC (zeige DCC Proteine) signaling with MT dynamics, resulting in specific defects of netrin-1 (zeige NTN1 Proteine)-mediated axon projection.
The remarkable high prevalence of TUBB3 expression in head and neck squamous cell carcinomas emphasizes its putative relevance as a target for future drugs targeting TUBB3
TUBB3 and TUBB4 are necessary for the transport and proper localization of N-cadherin (zeige CDH2 Proteine) within the plasma membrane.
The miR (zeige MLXIP Proteine)-34a/STMN1 (zeige STMN1 Proteine)/betaIII-tubulin axis maintains the microtubule cytoskeleton in osteosarcoma, and combining miR (zeige MLXIP Proteine)-34a with microtubule inhibitors can be investigated as a novel therapeutic strategy.
Tubulin beta 3 (TUBB3 (zeige TUBB5 Proteine)) expression was identified as a useful predictive factor for survival.
This is the first study that relates concurrent expression of Tubbeta3, ZEB1, and beta-catenin (zeige CTNNB1 Proteine) to abnormal epithelial and myofibroblast differentiation in idiopathic pulmonary fibrosis, providing indirect but robust evidence of miR (zeige MLXIP Proteine)-200 deregulation and epithelial to mesenchymal transition activation in idiopathic pulmonary fibrosis.
The authors found that transient TUBB3 activation, through ABCB1 (zeige ABCB1 Proteine), in response to the stimulation of FOXO3a (zeige FOXO3 Proteine) expression, significantly contributes to the cross-resistance of the paclitaxel-resistant cell population and consequently limits the efficacy of both agents where cancer cells have developed multiple resistance.
By linkage and sequencing analyses, we identified the mutation c.784C>T (p.R262C) in TUBB3 gene in six members of a Turkish family with congenital fibrosis of the extraocular muscles.
High TUBB3 expression is associated with Melanoma.
these results identify a broad spectrum of cancers that can at least sporadically express TUBB3. Testing of TUBB3 in cancer types eligible for taxane-based therapies could be helpful to identify patients who might best benefit from this treatment.
Here, we report that dissociation of UNC5C (zeige Unc5c Proteine) and polymerized TUBB3, the highly dynamic beta-tubulin (zeige TUBB Proteine) isoform in neurons, is essential for netrin-1 (zeige NTN1 Proteine)/UNC5C (zeige Unc5c Proteine)-promoted axon repulsion. These results not only provide a working model of direct modulation of MTs (zeige NEU2 Proteine) by guidance cues in growth cone navigation but also help us to understand molecular mechanisms underlying developmental brain disorders associated with TUBB3 mutations.
Tubb3 could be regulated by both Akt (zeige AKT1 Proteine) and Erk (zeige EPHB2 Proteine) pathways.
It findings reveal that expression of relatively low levels of TUBB3 in mitotic cells can be detrimental for their cytokinesis and underscore the importance of CIT-K (zeige CIT Proteine) in counteracting this event.
Results suggest that down syndrome cell adhesion molecule (zeige DSCAM Proteine) collaborates with deleted in colorectal cancer (zeige DCC Proteine) to regulate microtubule dynamics via direct binding to dynamic TUBB3 in Netrin-1 (zeige NTN1 Proteine)-induced axon branching.
determined the alpha-synuclein-binding domain of beta-III tubulin and demonstrated that a short fragment containing this domain can suppress alpha-synuclein accumulation in the primary cultured cells
Study shows the critical and specific role of Tubb3 on the stereotyped morphological changes and polarization processes that are required for initiating radial migration to the cortical plate.
this study reports that TUBB3, the most dynamic beta-tubulin (zeige TUBB Proteine) isoform in neurons, directly interacts with the netrin receptor DCC (zeige DCC Proteine), and that netrin-1 (zeige NTN1 Proteine) induces this interaction in primary neurons.
Access to a running wheel for 48h induced plastic changes in the expression of astrocyte beta-tubulin (zeige TUBB Proteine) (III). Expression was increased in the cerebellum while much smaller increases were observed in the other motor regions.
interaction between alpha-syn and beta-III tubulin (zeige TUBB Proteine) plays an important role in neuronal alpha-syn accumulation in an multiple system atrophy mouse model.
Expression of Tubb3, a beta (zeige SUCLA2 Proteine)-tubulin (zeige TUBB Proteine) isotype, is regulated by androgens in mouse and rat Sertoli cells.
the brown phenotype in C. porcellus is caused by a loss of function of the receptor MC1R
This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6.
class III beta-tubulin
, tubulin beta-3 chain
, tubulin beta-4 chain
, tubulin beta-III
, tubulin, beta, 3
, tubulin, beta, 4
, neuron-specific class III beta-tubulin
, tubulin beta3
, beta-tubulin 3
, tubulin, beta 3
, beta3 tubulin