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RhoA activated the downstream Wnt/betacatenin signaling pathway and inhibited the expression of apoptotic factors.
We identify HGF (zeige HGF Antikörper), acting through the c-Met receptor, as the key polarity-inducing morphogen (zeige SHH Antikörper), which acts to activate b1-integrin-dependent adhesion. HGF (zeige HGF Antikörper) and ECM (zeige MMRN1 Antikörper)-derived integrin signals co-operate via a c-Src (zeige SRC Antikörper)-dependent inhibition of the RhoA-ROCK1 (zeige ROCK1 Antikörper) signalling pathway via p190A (zeige GRLF1 Antikörper) RhoGAP (zeige ARHGAP1 Antikörper)
Extracellular Hsp90alpha mediates house dust mite-induced human bronchial epithelial barrier dysfunction by activating RhoA/MLC signaling, suggesting that eHsp90alpha is a potential therapeutic target for treatment of asthma.
This analysis showed a relative increase in the expression of E2F6 (zeige E2F6 Antikörper) in gastric adenocarcinoma with no lymph node metastasis (chi (2), P = 0.04 and OR, P = 0.08), while overexpression of RhoA and SMUG1 (zeige SMUG1 Antikörper) was found more often in the diffuse subtype of gastric adenocarcinoma as compared to the intestinal subtype.
This is the first study to verify the relationship of the expression of RhoA and Ezrin (zeige EZR Antikörper) proteins in vaginal tissue of Postmenopausal atrophic vagina.
blockage of RhoA/ROCK repressed the TAK1 (zeige MAP3K7 Antikörper)/NOD2 (zeige NOD2 Antikörper)-mediated NF-kappaB (zeige NFKB1 Antikörper) pathway in HaCaT cells exposed to UVB.
data suggest that TGF-beta (zeige TGFB1 Antikörper) stimulated the expression of ChPF (zeige CHPF Antikörper) and sGAG synthesis in nucleus pulposus cells through Smad3 (zeige SMAD3 Antikörper), RhoA/ROCK1 (zeige ROCK1 Antikörper) and the three MAPK (zeige MAPK1 Antikörper) signaling pathways.
a SDF-1 (zeige CXCL12 Antikörper)/CXCR4 (zeige CXCR4 Antikörper)-RhoA and RhoC (zeige RHOC Antikörper)-ROS (zeige ROS1 Antikörper)-cytoskeleton pathway that regulates Jurkat cell migration in response to SDF-1 (zeige CXCL12 Antikörper).
DIAPH3 (zeige DIAPH3 Antikörper) overexpression inhibits the migration and invasion of Triple-negative breast cancer by inhibiting RhoA-GTP (zeige AK3 Antikörper) expression.
Tyr42 phosphorylation of RhoA GTPase promotes tumorigenesis through NF-kappaB (zeige NFKB1 Antikörper).
GTP (zeige AK3 Antikörper)-RhoA and ROCK1 (zeige ROCK1 Antikörper) expression levels were markedly increased in a time-dependent manner in the ears and lungs of mice treated with penicillin.
RhoA modulates the choices of molar cuspal shape by coordinating adhesion junctions, actin distribution, and fibronectin (zeige FN1 Antikörper) localization to drive inner dental epithelium invagination.
Kctd13 deletion reduces synaptic transmission, which correlates with increased levels of RhoA, a KCTD13/CUL3 ubiquitin ligase substrate
Crmp4(-/-) OBs exhibited enhanced activation of RhoA/focal adhesion kinase (FAK) signaling that led to cytoskeletal changes with increased cell spreading.
Codepletion of the actomyosin regulator RhoA and Afadin (zeige MLLT4 Antikörper) results in defects in the central lumens and arrests lumen remodeling
Hydrogen peroxide oxidizes RhoA at Cys16 and Cys20, and activates RhoA via Vav2 (zeige VAV2 Antikörper).
These results reveal a novel signaling network, the Sema4D (zeige SEMA4D Antikörper)-RhoA-Akt (zeige AKT1 Antikörper) signal cascade, that coordinates cellular function and morphology and highlights the importance of specific spatiotemporally restricted components of a signaling pathway in the regulation of ameloblast differentiation.
RhoA deficiency could disrupt podocyte cytoskeleton and induce podocyte apoptosis by inhibiting YAP/dendrin signal.
These results suggested that, in addition to inhibiting Noggin (zeige NOG Antikörper) transcription, RhoA activity in wild-type murine embryonic stem cells also prevented neural differentiation by limiting Noggin (zeige NOG Antikörper) secretion.
Mgc's GAP activity down-regulates the active populations of RhoA and Rac1 at localized regions of epithelial cells and is necessary for successful cytokinesis and cell-cell junction structure
Data show that shortly after anaphase onset oocytes and embryonic cells exhibit cortical waves of Rho activity and F-actin polymerization.
CASZ1 (zeige CASZ1 Antikörper)/Egfl7 (zeige EGFL7 Antikörper)/RhoA pathway is necessary for promoting endothelial cell behaviors associated with proper vascular assembly.
RhoA can be considered a component of the intracellular pattern formation system.
Kazrin (zeige KAZ Antikörper) interacts with ARVCF (zeige ARVCF Antikörper)-catenin, spectrin and p190B (zeige ARHGAP5 Antikörper) RhoGAP (zeige ARHGAP1 Antikörper), and modulates RhoA activity.
Morphogenesis of the primitive gut tube is generated by Rho/ROCK/myosin II-mediated endoderm rearrangements.
RhoA and membrane fluidity mediates the spatially polarized Src (zeige SRC Antikörper)/FAK (zeige PTK2 Antikörper) activation in response to shear stress.
the Lbc (zeige AKAP13 Antikörper)/alpha-catulin (zeige CTNNAL1 Antikörper) axis participates in 5-HT (zeige DDC Antikörper)-induced PASMC mitogenesis and RhoA/ROCK signaling, and may be an interventional target in diseases involving vascular smooth muscle remodeling.
The RhoA/ROCK signaling pathway is an important negative regulator of vascular calcification.
Vascular endothelial-cadherin signals through RhoA and actin cytoskeletal and affects cell-matrix adhesion
Thrombospondin has a role in inducing RhoA inactivation through FAK (zeige PTK2 Antikörper)-dependent signaling to stimulate focal adhesion disassembly
KCl directly increased Rho and ROCK activities in a concentration-dependent fashion that paralleled closely the effect of KCl on lung smooth muscle tone and [Ca(2 (zeige CA2 Antikörper)+)](i), as well as the voltage-dependent Ca(2 (zeige CA2 Antikörper)+) currents
the Rho-ROCK signal pathway contributes to VEGF (zeige VEGFA Antikörper)-induced hyperpermeability. Myosin light-chain phosphorylation and actin stress fiber formation occur concomitantly with the increase in permeability upon VEGF (zeige VEGFA Antikörper) stimulation.
Formation of polygonal actin network in endothelial cells is a novel rhoA associated response to hypertonic stress.
Cadherins, RhoA and Rac1, have important roles in mechanotransduction and that endothelial and smooth muscle cells use different mechanisms to respond to stretch.
Results indicate that hypergravity induces ATP release and actin reorganization via RhoA activation and FAK (zeige PTK2 Antikörper) phosphorylation, thereby activating cell proliferation and migration in bovine aortic endothelial cells.
Pseudorabies virus US3 expression led to RhoA phosphorylation at serine 188 to induce actin rearrangements.
Data indicate that TNF-alpha (zeige TNF Antikörper) stimulates Rac (zeige AKT1 Antikörper), ADAM17/TACE (zeige ADAM17 Antikörper), and RhoA through the guanine nucleotide exchange factor (zeige ARHGEF12 Antikörper) (GEF)-H1 (zeige ARHGEF2 Antikörper).
Contractile pulmonary arterial myocytes exhibit marked Rho-dependent actin polymerization in hypoxia, with increased active RhoA and LIMK (zeige LIMK1 Antikörper) phosphorylation.
Results suggest that Rac1 and RhoA are regulated by TGFbeta1 (zeige TGFB1 Antikörper) in the process of endothelial tube formation in collagen I gels.
The concentration of RhoA mRNA and activated RhoA enzyme were greater in urothelium than in detrusor. Rho kinase (zeige ROCK1 Antikörper) inhibitor Y-27632 showed a stronger inhibitory effect in detrusor with intact urothelium.
Thrombin (zeige F2 Antikörper) stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1 (zeige F2R Antikörper), RhoA, and myocardin (zeige MYOCD Antikörper).
Activating Rho could be beneficial to suppress Kras mutant-induced liver malignancies.
Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton.
Aplysia ras-related homolog 12
, oncogene RHO H12
, ras homolog gene family, member A
, rho cDNA clone 12
, small GTP binding protein RhoA
, transforming protein RhoA
, Rho-related protein HP1
, ras homolog D
, ras homolog gene family, member D
, rho-related GTP-binding protein RhoD
, Ras family member A
, Rho family GTPase
, aplysia ras-related homolog A
, aplysia ras-related homolog A1
, aplysia ras-related homolog A2
, ras homolog A1
, ras homolog A2
, ras homolog gene family, member A1
, ras homolog gene family, member A2
, plysia ras-related homolog A2
, rho1 GTP-binding protein
, RhoA GTPase
, Rho A