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Identified SUMO2 as a most efficient calcineu (zeige NFATC1 Proteine)rin-NFAT (Cn-NFAT) activator. SUMO2-mediated activation of Cn-NFAT signaling in cardiomyocytes translated into a hypertrophic phenotype.
We further show that the SUMO2 pathway acts independently of exogenous C-MYC (zeige MYC Proteine) expression and in parallel with small-molecule enhancers of reprogramming. Importantly, suppression of SUMO2 also promotes the generation of human induced pluripotent stem cells .
Increased post-translational modification of proteins by SUMO-2/3 is a cytoprotective response against cell stress induced by ischaemia and reperfusion.
Sumoylation of PML (zeige PML Proteine) with SUMO2 by UBC9/UBE2I (zeige UBE2I Proteine) can lead to formation of polymeric SUMO chains. Data suggest that coordination of growing poly-SUMO chain with "back side" binding site on UBC9/UBE2I (zeige UBE2I Proteine) appears to be required for SUMO chain elongation on PML (zeige PML Proteine). (PML (zeige PML Proteine) = promyelocytic leukemia protein (zeige PML Proteine); SUMO2 = small ubiquitin-like modifier 2; UBC9/UBE2I (zeige UBE2I Proteine) = ubiquitin-conjugating enzyme (zeige Ube2t Proteine) UBC9/UBE2I (zeige UBE2I Proteine))
The data demonstrate that SUMO2 conjugation and SENP3 (zeige ULP1 Proteine)-driven deSUMOylation of PELP1 (zeige PELP1 Proteine) is instrumental for ordered progression of ribosome maturation, and they provide molecular insight into the dynamics of ribosome maturation.
This study reveals an essential role of SUMOylated FADD (zeige FADD Proteine) in Drp1 (zeige CRMP1 Proteine)- and caspase-10 (zeige CASP10 Proteine)-dependent necrosis.
This study demonstrated that two polymorphisms of SUMO2 were significantly associated with an increased risk of AD in female group.
FOXP2 (zeige FOXP2 Proteine) can be modified with all three human SUMO proteins and that PIAS1 (zeige PIAS1 Proteine) promotes this process.
Hsp27-Ubc9 pathway recognizes the conformation of mutant CFTR which leads to its SUMO-2 conjugation and degradation by the ubiquitin-proteasome system.
Data suggest that RAP80 (zeige UIMC1 Proteine) SIM (zeige SIM2 Proteine) (SUMO interacting motif) binds SUMO-2; both specificity and affinity are enhanced through phosphorylation of canonical CK2 (zeige CSNK2A1 Proteine) (casein kinase 2) site within the SIM (zeige SIM2 Proteine).
SUMO2-mediated activation of calcineurin-NFAT (zeige NFATC1 Proteine) signaling in cardiomyocytes translated into a hypertrophic phenotype. Increased SUMO2-mediated sumoylation in models of cardiomyopathy were observed.
integrity is required for PLK1 localization with SUMO-1 (zeige SUMO1 Proteine) but not with SUMO-2/3. Inhibition of SUMOylation disrupts proper meiotic bipolar spindle organization and spindle-kinetochore attachment.
a regulatory role of ZNF451-1 in fine-tuning physiological PML (zeige PML Proteine) levels
SUMO-2 inhibits aggregation of CPEB3 (zeige CPEB3 Proteine).
The present study used immunohistochemical and immunoblot analysis with the different developmental stages of mice and demonstrated the developmentally regulated distribution of SUMO2/3 in the brain.
SUMO-2-Tg mouse lines exhibited cardiomyopathy with various severities. SUMO-2 directly regulated apoptosis by at least partially targeting calpain 2 (zeige CAPN2 Proteine) and calpastatin (zeige CAST Proteine).
Results indicate that a functional SUMO1 (zeige SUMO1 Proteine)-3 expression is essential for emotionality and cognition
Expression levels and not functional differences between SUMO2 and SUMO3 (zeige SUMO3 Proteine) are critical for normal embryogenesis.
Stress-induced phosphorylation of Thr486 in c-Myb (zeige MYB Proteine) by p38 (zeige CRK Proteine) mitogen-activated protein kinases attenuates conjugation of SUMO-2/3.
post-ischemic activation of SUMO2/3 conjugation may define the fate of neurons exposed to a transient interruption of blood supply
cyclin E (zeige CCNE1 Proteine) is dynamically and highly conjugated to SUMO2/3 on chromatin, independently of Cdk2 (zeige CDK2 Proteine) activity and origin activation.
Functionally similar to human SUMO2 and SUMO3, Arabidopsis SUMO1 and 2 can form chains, even though they do not possess a consensus SUMOylation motif. The surprising finding that plants have dedicated enzymes for chain synthesis implies a specific role for SUMO chains in plants
we provide evidence for the existence of a preferential conjugation of AtSUMO1/2 compared with AtSUMO3/5, which is determined by a role of the E1-activating enzyme in SUMO paralogue discrimination.
SUM3 (zeige SUMO3 Proteine) promotes plant defense downstream of salicylic acid, while SUM1 (zeige SUMO1 Proteine) and SUM2 together prevent salicylic acid accumulation in noninfected plants.
SIZ1-mediated conjugation of SUMO1 (zeige SUMO1 Proteine) and SUMO2 to other intracellular proteins is essential in Arabidopsis, possibly through stress-induced modification of a potentially diverse pool of nuclear proteins.
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
SMT3 homolog 2
, SMT3 suppressor of mif two 3 homolog 2
, sentrin 2
, small ubiquitin-related modifier 2
, ubiquitin-like protein SMT3A
, ubiquitin-like protein SMT3B
, SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)
, SMT3 supressor of mif two 3 homolog 2
, small ubiquitin-related modifier 2-B
, MIF2 suppressor
, Ubiquitin-like protein SMT3B