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Human Polyclonal HSD17B3 Primary Antibody für ELISA, WB - ABIN561372
Locke, Guns, Lubik, Adomat, Hendy, Wood, Ettinger, Gleave, Nelson: Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer. in Cancer research 2008
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Horse (Equine) Polyclonal HSD17B3 Primary Antibody für WB - ABIN2785439
Bertin, Dury, Ouellet, Pelletier, Labrie: Localization of the androgen-synthesizing enzymes, androgen receptor, and sex steroids in the vagina: possible implications for the treatment of postmenopausal sexual dysfunction. in The journal of sexual medicine 2014
Enzyme activities of 3-betaHSDH increase as the sound pressure levels increase in adrenal cortex zona fasciculate polygonal cells.
High 4-tert-Octylphenol doses affect the cytoarchitecture of MA-10 Leydig cells as well as attenuate 3beta-HSD and AR expression.
Pubertal Cd exposure markedly reduced mRNA and protein levels of testicular StAR, P450scc, P450(17alpha) and 17beta-HSD in mice.
mutations of HSD17B3 in three Chinese patients with 46,XY Disorders of Sex Development
The 17beta-HSD3 G289S substitution, previously reported in other patients with 46,XY disorders of sex development, is a polymorphism that does not cause the disorder.
The study shows that 17-beta-HSD-3 deficiency is not an uncommon disorder among Egyptian DSD cases. It was evidenced that the mutational profile of the disease is rather heterogeneous, relatively different from those reported in other populations, and has a high degree of novel genetic defects.
analysis of Tunisian patients with mutations in the gene encoding 17beta-hydroxysteroid dehydrogenase type 3 and a founder effect
Mutation G133R in HSD17B3 results in almost complete loss of enzyme activity since it interferes with binding of cofactor NADPH.
Mutations in the HSD17B3 gene is associated with Disorders of Sex Development.
Expression of the genes HSD3B1, HSD17B3, and SRD5A2 was significantly increased in BPH tissues compared to normal adjacent prostate tissues.
Missense mutation in HSD17B3 gene in a 46, XY adolescent is associated with primary amenorrhea and virilization at puberty
38% of unrelated 46,XY females with unknown diagnosis in the study have HSD17B3 mutations predicted to cause HSD17B3 deficiency.
These results suggest that the HSD17B3 G289S polymorphism may be a potential risk modifier for hypospadias.
68 males with testicular 17beta-HSD deficiency were identified among a highly inbred Arab population in Israel as affected with male pseudohermaphroditism. [Review]
The H8 haplotype of the HSD17B3 gene was significantly associated with increased risks of acne vulgaris in Han Chinese from the Southwest China.
Case Report: rare form of 46,XY disorders of sexual development, associated to a novel gene nonsense mutation of HSD17B3 gene.
Circulating testosterone levels were higher in men with early repolarization electrocardiograms.
Androgen-metaboliizing enzymes, 17betaHSD5 and 5alpha1 immunoreactivity was decreased in metastatic lymph nodes of breast cancers.
in two sisters with 17beta hydroxysteroid dehydrogenase type 3 deficiency, a heterozygous mutation for both a known splicing mutation and a previously unreported amplification mutation of the HSD17B3 gene were identified
Results demonstrate a cytoplasmic orientation of 17beta-HSD3 and dependence on glucose-6-phosphate dehydrogenase-generated NADPH, explaining the lack of a direct functional coupling with the luminal 11beta-HSD1-mediated glucocorticoid metabolism
oxazolidinediones and thiazolidinediones are potent 17beta-hydroxysteroid dehydrogenase type 3 inhibitors
XY sex reversal is sufficiently variable in 17betaHSD3 deficiency to cause problems in accurate diagnosis, particularly in distinguishing it from Androgen Insentitivity Syndrome in undervirilized males..
This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia.
17(beta)HSD type 3
, 17-beta-HSD 3
, 17-beta-hydroxysteroid dehydrogenase type 3
, testicular 17-beta-hydroxysteroid dehydrogenase
, testosterone 17-beta-dehydrogenase 3
, estradiol 17 beta-dehydrogenase 3
, short chain dehydrogenase/reductase family 12C, member 2