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anti-Mouse (Murine) HSD17B3 Antikörper:
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Human Polyclonal HSD17B3 Primary Antibody für ELISA, WB - ABIN561372
Locke, Guns, Lubik, Adomat, Hendy, Wood, Ettinger, Gleave, Nelson: Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer. in Cancer research 2008
Show all 3 Pubmed References
Horse (Equine) Polyclonal HSD17B3 Primary Antibody für WB - ABIN2785439
Bertin, Dury, Ouellet, Pelletier, Labrie: Localization of the androgen-synthesizing enzymes, androgen receptor, and sex steroids in the vagina: possible implications for the treatment of postmenopausal sexual dysfunction. in The journal of sexual medicine 2014
High 4-tert (zeige TERT Antikörper)-Octylphenol doses affect the cytoarchitecture of MA-10 Leydig cells as well as attenuate 3beta-HSD (zeige HAL Antikörper) and AR expression.
Pubertal Cd exposure markedly reduced mRNA and protein levels of testicular StAR, P450scc (zeige CYP11A1 Antikörper), P450 (zeige POR Antikörper)(17alpha) and 17beta-HSD (zeige HSD17B1 Antikörper) in mice.
The 17beta-HSD3 (zeige SPATA7 Antikörper) G289S substitution, previously reported in other patients with 46,XY disorders of sex development, is a polymorphism that does not cause the disorder.
The study shows that 17-beta-HSD-3 deficiency is not an uncommon disorder among Egyptian DSD (zeige FADS1 Antikörper) cases. It was evidenced that the mutational profile of the disease is rather heterogeneous, relatively different from those reported in other populations, and has a high degree of novel genetic defects.
analysis of Tunisian patients with mutations in the gene encoding 17beta-hydroxysteroid dehydrogenase (zeige HSD17B7 Antikörper) type 3 and a founder effect
Mutation G133R in HSD17B3 results in almost complete loss of enzyme activity since it interferes with binding of cofactor NADPH.
Mutations in the HSD17B3 gene is associated with Disorders of Sex Development.
Expression of the genes HSD3B1 (zeige HSD3B1 Antikörper), HSD17B3, and SRD5A2 (zeige SRD5A2 Antikörper) was significantly increased in BPH (zeige GLI3 Antikörper) tissues compared to normal adjacent prostate tissues.
Missense mutation in HSD17B3 gene in a 46, XY adolescent is associated with primary amenorrhea and virilization at puberty
38% of unrelated 46,XY females with unknown diagnosis in the study have HSD17B3 mutations predicted to cause HSD17B3 deficiency.
These results suggest that the HSD17B3 G289S polymorphism may be a potential risk modifier for hypospadias.
This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia.
17(beta)HSD type 3
, 17-beta-HSD 3
, 17-beta-hydroxysteroid dehydrogenase type 3
, testicular 17-beta-hydroxysteroid dehydrogenase
, testosterone 17-beta-dehydrogenase 3
, estradiol 17 beta-dehydrogenase 3
, short chain dehydrogenase/reductase family 12C, member 2