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Data show that in tissue and secreted cells from the infected mammary glands, 25-hydroxyvitamin D(3) 1alpha-hydroxylase (1alpha-OHase; CYP27B1) gene expression was significantly increased compared to expression in tissue and cells from the healthy mammary tissue.
Dietary habits, lifestyle, and polymorphisms in VDR (ApaI), CYP24A1 (zeige CYP24A1 Proteine) (rs6013897, rs158552, rs17217119) and CYP27B1 (rs10877012) were associated with a higher risk of colorectal cancer
primary human osteoblasts in the presence of high calcium concentrations increase their CYP27B1 mRNA levels by 1.3-fold
The multiple sclerosis-associated regulatory variant rs10877013 affects expression of CYP27B1 and VDR under inflammatory or vitamin D stimuli.
The local regulation of vitamin D in sinonasal tissue during chronic rhinosinusitis may be independent of serum 25(OH)D levels. Vitamin D may be dysregulated at multiple levels, with decreased transcription of the metabolic gene CYP27B1 and increased transcription of the catabolic gene CYP24A1 (zeige CYP24A1 Proteine).
IL-13 (zeige IL13 Proteine) suppressed cyp27b1 expression in CD14 (zeige NDUFA2 Proteine)(+) cells. IL-13 (zeige IL13 Proteine) increased expression of miR (zeige MLXIP Proteine)-19a in CD14 (zeige NDUFA2 Proteine)(+) cells. IL-13 (zeige IL13 Proteine) suppresses cyp27b1 expression in peripheral CD14 (zeige NDUFA2 Proteine)(+) cells via up regulating miR (zeige MLXIP Proteine)-19a expression.
Uremic serum increased the intracellular expression of IL-6 (zeige IL6 Proteine), IFN-gamma (zeige IFNG Proteine), TLR7 (zeige TLR7 Proteine), TLR9 (zeige TLR9 Proteine), VDR, CYP27b1 and CYP24a1 (zeige CYP24A1 Proteine)
Women with Recurrent Miscarriage have a lower level of CYP27B1 expression in chorionic villi and decidua compared with normal pregnant women, suggesting that reduced CYP27B1 expression may be associated with Recurrent Miscarriage.
Mutation in CYP27B1 is associated with Vitamin D-Dependent Rickets Type 1.
Male placental cotyledons showed reduced basal CYP27B1 and cathelicidin gene expression compared to females.
Expression of CYP27B1 was in spermatozoa from healthy controls compared with infertile men, however the percentage of spermatozoa expressing CYP27B1 was not significantly higher.
These results reveal that differential regulation of Cyp27b1 expression represents a mechanism whereby 1,25(OH)2D3 can fulfill separate functional roles, first in the kidney to control mineral homeostasis and second in extra-renal cells to regulate target genes linked to specific biological responses.
The data indicate that abnormal osteoclastogenesis due to the absence of CYP27B1 expression, consistent with the notion that endogenous metabolism of 25-hydroxyvitamin D optimizes osteoclastogenesis and ameliorates the resulting activity of mature osteoclasts.
The absence of 25-hydroxyvitamin D3-1alpha-hydroxylase potentiates the suppression of EAE in mice by ultraviolet light.
Cyp27b1(-/-) mice exhibited hypocalcemia, growth defects, and skeletogenesis dysfunction, similar to Vdr(-/-) mice, but do not display alopecia
Findings demonstrate that in-tumor CYP27B1 1-alpha-hydroxylase activity plays a crucial role in controlling early oncogene (zeige RAB1A Proteine)-mediated mammary carcinogenesis events, at least in part by modulating tumoral cell NF-kappaB (zeige NFKB1 Proteine) p65 (zeige NFkBP65 Proteine) nuclear translocation.
the effect of 25-hydroxyvitamin D-1-alpha-hydroxylase on the atherosclerosis disease both in apolipoprotein (apo) E (zeige APOE Proteine)-/- mice and wild-type mice, was investigated.
P450C1 alpha deficiency results in abnormal calcium handling and cardiac dysfunction in mice with defective vitamin D signaling.
Throughout the male reproductive tract specific bands of CYP27B1 are determined.
observed a 3- to 10-fold increase in CYP27B1 mRNA abundance in the lung, spleen, aorta and testis of FGF-23 (zeige FGF23 Proteine) null/1alpha-Luc mice
Data show that the absence of either of the two key hydroxylases, vitamin D 25-hydroxylase (CYP2R1 (zeige CYP2R1 Proteine)) or vitamin D 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1)neither inhibits nor enhances the development of experimental autoimmune encephalomyelitis (EAE).
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.
cytochrome P450, family 27, subfamily B, polypeptide 1
, 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
, mitochondrial 25 hydroxyvitamin D3-1alpha-hydroxylase
, 25 hydroxyvitamin D3-1-alpha hydroxylase
, 25-OHD-1 alpha-hydroxylase
, VD3 1A hydroxylase
, calcidiol 1-monooxygenase
, cytochrome P450 subfamily XXVIIB polypeptide 1
, cytochrome P450C1 alpha
, cytochrome P450VD1-alpha
, cytochrome p450 27B1
, 25-hydroxyvitamin D(3) 1-alpha-hydroxylase
, P450C1 alpha
, cytochrome P450 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase)
, cytochrome P450 subfamily XXVIIB (25-hydroxyvitamin D-1-alpha-hydroxylase) polypeptide 1
, cytochrome P450, 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase)
, cytochrome P450, subfamily 27b, polypeptide 1
, 25(OH)D 1alpha-hydroxylase
, 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor (25-OHD-1 alpha-hydroxylase) (25-hydroxyvitamin D3 1-alpha-hydroxylase) (VD3 1A hydroxylase) (P450C1 alpha) (P450VD1-alpha)
, 25-hydroxyvitamin D3 1alpha-hydroxylase
, cytochrome P450, 27b1