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Polymorphism in CYP19A1 is not associated with polycystic ovary syndrome.
CYP19A1 was the only gene harboring single nucleotide polymorphisms that were significantly associated with prostate cancer risk
CYP19A1 mRNA expression and aromatase activity during syncytialization of primary human villous trophoblast cells at term
in postmenopausal women, aromatase activity could be an important determinant of skeletal health.
Fungicide ziram may disrupt the placental steroid production. In the present study, we investigated the effects of ziram on steroid formation in human placental cell line JEG-3 cells and on HSD3B1 and aromatase in the human placenta. Ziram did not inhibit progesterone production in JEG-3 cells and HSD3B1 activity at 100muM... ziram is a potent inhibitor of human aromatase.
This study demonstrated the existence of an AMH-FOXL2 relationship in hGCs. AMH is capable of increasing both gene and protein expression of FOXL2. Because FOXL2 induces AMH transcription, these ovarian factors could be finely regulated by a positive feedback loop mechanism to preserve the ovarian follicle reserve.
The present study reports on the synthesis of pituitary aromatase, its regulation by gonadal steroids, and the physiological roles of aromatase on pituitary endocrine cells. The involvement of aromatase in the pathogenesis of pituitary tumors, mainly prolactinomas, through the auto-paracrine production of estradiol is reviewed. [review]
CYP19A1 Val80, a genetic polymorphism related to the conversion of testosterone into estrogen, significantly contributes to individual differences in self-construal and subjective well-being.
The findings indicate that the CYP19 alleles rs727479A/C and rs700519C/T might be associated with the pregnancy outcome after assisted reproductive technology in patients with polycystic ovary syndrome.
significant prognostic roles of ERalpha, ERbeta and aromatase were discovered in the in prostate cancer specimens of our large multicenter cohort.
These studies suggest an association between adiposity, aromatase estrogenic capacity and atrial arrhythmogenicity.
To our knowledge, this is the first study showing that the CYP17 T-34C and CYP19 T
Changes in the CYP19A1 expression in adipose tissue stromal vascular fraction cells, induced by free acids, correlated positively with BMI of patients but only in group of obese or overweight women.
In conclusion, activated Smad3 proteins can bind to P450arom promoter -705/+87 bp region, responsive to activin A in endometrial stromal cells, which can promote P450arom transcription.
polymorphisms not associated with late miscarriage
this study illustrated that the brain-specific alternate promoter PI.f derived CYP19 expression can be regulated by DNA methylation.
sex steroid hormones and sex hormone binding globulin levels, CYP17 MSP AI (-34T:C) and CYP19 codon 39 (Trp:Arg) variants in children with developmental stuttering
RET inhibitors could both impair primary tumor growth and tumor dissemination, thereby providing a potential therapeutic advantage when used in combination with aromatase inhibitors in postmenopausal ER+ breast cancers.
We suggest from these studies that overexpression of aromatase in breast tissue and its resultant increase in estradiol levels may contribute to the later development of breast cancer in women with atypical ductal hyperplasia
As regards the CYP19A1 variant, genotype 11 (del/del) was more frequent in patients than in controls (OR=1.85; 95% CI 1.06-3.22; P=0.03).
We found that cyp19a1 expression is highly regionalized in the brains of both sexes.
Cyp19a1 expression leads to female sex determination in Xenopus laevis.
brain-specific promoter/exon I.f of the cyp19a1 has cis-elements for several transcriptional factors
binding sequences to a specific trans-activating factor upstream of the p450 aromatase promoter II
The ontogenetic patterns of Aro, Srd5a1 and Srd5a2 suggest that these genes are involved in sexual differentiation of gonads and brain already in early developmental stages.
co-localization of estrogen receotirs with aromatase in horse trophoblast suggests auto- or intracrine functions of oestrogens in this cell type
liver receptor homolog (LRH)-1, not CYP19A1, is a direct functional target of miR-1275.
CYP19A1 is involved in sperm fertility and its expression in sperm plays an important role in fertilization.
P450arom was expressed in all layers of the arterial and venous vessels of the spermatic cord with higher intensity of staining in June long daylight) compared to December(short daylight).
Decreased estradiol production via suppression of aromatase may be one of the mechanisms by which miR-378 regulates the maturation of cumulus-oocyte complexes.
This study tested whether prenatal and neonatal exposure to antiandrogen flutamide affected ovarian 17beta-estradiol synthesis and the associated gene expression in large antral follicles of adult pigs.
show that micro-RNA378 (miR-378) is spatiotemporally expressed in porcine granulosa cells, the cells that generate estradiol in the ovary during follicular development, in an inverse manner compared with the expression of aromatase
Pig ejaculated spermatozoa express aromatase.
The presence of aromatase and 11beta-HSD 2 in Leydig cells increased, together with germ and Sertoli cell numbers.
This study demonstrates that transferrin had a dose-dependent inhibitory effect on follicle stimulating hormone-stimulated aromatase activity.
This study demonstrated that Aromatase expression in spinal cord and medulla in sex difference.
Increased adipose tissue aromatase activity reduces adipose tissue inflammation and improves insulin sensitivity in male mice.
Aromatase-knockout (ArKO) mice cannot synthesize estrogens in vivo. Male ArKO mice developed hepatic steatosis accompanied by high testosterone levels.
results show that the Aha1-Hsp90-PKM2/HIF-1alpha axis mediates the induction of aromatase in Li-Fraumeni Syndrome.
aromatase could modulate pituitary LH-positive cells in males through local estradiol synthesis.
Findings indicate that sex chromosome factors determine sex differences in aromatase expression in the stria terminalis and in the anterior amygdaloid area of mouse embryos.
CELF1 downregulates Cyp19a1 (Aromatase) posttranscriptionally to achieve high concentrations of testosterone compatible with spermiogenesis completion.
Aromatase plays an important role in the survival of metastatic ERalpha breast cancer cells by suppressing anoikis.
aromatase may play a key role in the pathogenesis of Sjogren syndrome-like lesions by controlling the target organ and adipose tissue-associated macrophage; increased MPC1 protein expression has a role in adiposity
The protective effect of female gender on abdominal aortic aneurysms is due to estrogen synthesis and requires the presence of both ovarian and extragonadal/peripheral aromatase.
Aromatase signaling is common in the mouse brain; locally synthesized brain estrogens could mediate biological effects by activating pre- and post-synaptic estrogen alpha and beta receptors, and androgen receptors.
Male Aromatase knockout mice develop hepatic glucose intolerance.
Cerebrovascular endothelial aromatase plays an important and sexually dimorphic role in cerebrovascular function and that aromatase inhibitors in clinical use may have cardiovascular consequences in both males and females.
CYP19A1 gene is driven by promoters PII, I.4, and I.3 in the seminal vesicles, and by promoters PII and I.4 in the urinary bladder.
Lhx2 is involved in the transcriptional regulation of aromatase in the rodent brain.
Glucocorticoids alter aromatase expression in the hypothalamus and might regulate gonadotropin pulses and the menstrual cycle.
Aromatase-deficient mice displayed increased cortical neuronal density and occasional cortical heterotopias
Data show that the human aromatase gene can be expressed via its native promoters in a wide variety of mouse tissues and in a distribution pattern nearly identical to that of humans.
expression level of estrogen receptors and aromatase in testis during aging
in granulosa cells of dominant follicles the concentration of CYP19P1 mRNA was very low compared to CYP19A1 mRNA. CONCLUSIONS: CYP19P1 and CYP19A1 transcripts might interfere in placental cotyledons
These data suggest that a major reason why CYP19A1 is not expressed in luteinized cells (and the corpus luteum) of ruminants may be the stimulatory effect of FOXL2, which does not appear to be the case in the human and rat.
This study evaluated the relationships among aromatase, IGF-1, IGF2R, and FSH levels expressed in ovarian follicles of cattle selected for twin pregnancies.
Data indicated de novo DNA methylation fter the luteinizing hormone-induced down-regulation of CYP19A1 expression, suggesting that DNA methylation might play a role for permanent silencing of previously down-regulated genes.
P450(AROM) is localized in the cytoplasm and only seldom present in the fine extensions of the cells in frontal cortex.
Granulosa and theca of well-characterized large bovine follicles were isolated before and after the LH surge. CYP19A1, HSD3B1, and CYP17A1 transcripts were quantified by real-time PCR (qPCR) and the chromatin condensation was determined.
DNA methylation may have a role in the permanent shutdown of promoter 2-directed cytochrome P450 19A1(CYP19A1) expression in large (granulosa derived) lutein cells
fetal ovary of cattle has the steroidogenic enzyme aromatase to convert androgens to estradiol-17beta, and estrogen receptors alpha and beta to facilitate an estrogen response within the fetal ovary
granulosa cell clustering is accompanied by marked increases in FSHr, IGF-1r, and p450 arom expression, and precedes induction and subsequent peak E2 production
demonstrates that cattle and sheep use different promoters to direct aromatase(Cyp19) expression during pregnancy
Promoter-2-derived high-level expression of Cyp19 might be controlled by cell-type-specific DNA methylation.
CYP19 is regulated by multiple pathways in granulosa cells
second quarter of the gestation is the developmental stage which represents a critical period for hypothalamic differentiation in bovine ontogenesis.
Serum free culture conditions significantly enhanced Cyp17 and Csh1 but not Hsd3b expression in trophoblast.
CYP19 promoters are differentially methylated in ovine and bovine placental tissues of foetal and maternal origin.
Administration of CART in vivo into follicles at the early dominance stage reduced follicular fluid estradiol concentrations and granulosa cell CYP19A1 mRNA.
The CYP19/PvuII allele frequencies were as follows: A -0.91 and B -0.09. The highest average heterozygosity rate was found in herd A (0.2108).
Relative mRNA expression for insulin and FSH receptors and cytochrome P450 aromatase in cultured follicles.
cyp19a1a is expressed early during development, before the histological differentiation of the gonads, and the down-regulation of cyp19a1a expression is likely responsible for the testicular differentiation.
Knocking down the expression of gdf9 and cyp19a1a with vivo-morpholinos caused a male-skewed sex ratio.
Mutant zebrafish lines lacking the ovarian aromatase gene (cyp19a1a) leads to all-male offspring, suggesting that aromatase plays a critical role in directing ovarian differentiation and development.
Dual functions of the cyp19a1a gene during sex differentiation: cyp19a1a is not only indispensable for female sex differentiation but also required for male sex differentiation.
The whole-body androgen levels, follicle-stimulating hormone beta and luteinizing hormone beta protein levels in the pituitary, and transcript levels of genes known to be involved in spermatogenesis and steroidogenesis in the testes were significantly higher in the cyp19a1a mutant and aromatase double-mutant males than in the wild-type and cyp19a1b mutant male.
The results from the present study strongly suggest that DNA methylation is one of mechanisms that is involved in the regulation of cyp19a1a gene expression during folliculogenesis
Data show that cytochrome P450 enzymes Cyp17-I, Cyp11c1, Cyp19a1a and Cyp19a1b and one of their regulators forkhead protein Foxl2a were detected both in the testis and ovary.
Data indicate taht monocrotophos (MCP) exposure modulated gene expression of forkhead transcription factor gene L2 (foxl2), doublesex/mab-3 related transcription factor 1 (dmrt1), gonadal aromatase (cyp19a1a) and brain aromatase (cyp19a1b).
The differential expression of the aromatase genes, particularly CYP19A2 in the brain, suggests that the two aromatase genes play different roles in the reproductive behavior and/or physiology of bony fish.
zebrafish Anti-Mullerian hormone (Amh) is regulated by sox9a, sox9b, and cyp19a1a during gonad development
These results demonstrate seasonal and sex differences in brain aromatase mRNA expression in a teleost fish and suggest a role for aromatase in the expression of vocal-acoustic and alternative male reproductive phenotypes.
These analyses suggest that variants of CYP19 are not associated with risk of breast cancer.
amh is a candidate gene down-regulating cyp19a1a, leading to "juvenile ovary-to-testis" transformation.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity\; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants.
, cytochrome P-450AROM
, cytochrome P450 19A1
, cytochrome P450, subfamily XIX (aromatization of androgens)
, estrogen synthase
, estrogen synthetase
, flavoprotein-linked monooxygenase
, microsomal monooxygenase
, Cytochrome P450, 19, aromatase
, cytochrome P450 family 19 subfamily a
, cytochrome P450, subfamily 19
, p450 aromatase A
, cytochrome P450 aromatase
, cytochrome P450 17-alpha
, cytochrome P450 19 type I
, cytochrome P450, family19, subfamily A, polypeptide 1
, cytochrome P450, 19, aromatase
, cytochrome P450, family XIX (conversion of androgen to estrogen), aromatase
, Cytochrome P-450AROM
, Cytochrome P450 19A1
, Estrogen synthase
, aromatase cytochrome P450
, cytochrome P450 19A1a
, cytochrome P450, 19a
, P-450 aromatase
, cytochrome P-450 aromatase