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In adult mouse testes, strong Cubn immunoreactivity was found in the elongating spermatids. In Sertoli cells and peritubular cells, Cubn immunoreactivity was weak throughout the testis development. In the inter-stitium, Cubn immunoreactivity was found in foetal Leydig cells, was weak to negligible in the stem cells and progenitor Leydig cells and was strong in immature and adult Leydig cells.
Cubilin deficiency reduces renal salvage and delivery back to the blood of albumin a (zeige ALB ELISA Kits)nd apolipoprotein (apo)A-I (zeige APOA ELISA Kits), which decreases blood levels of albumin and apoA-I (zeige ALB ELISA Kits)/HD
cubilin and megalin (zeige LRP2 ELISA Kits) mRNA expression is under epigenetic control
plasma membrane binding of Fgf8 (zeige FGF8 ELISA Kits), and most likely of the Fgf8 (zeige FGF8 ELISA Kits) family members Fgf17 (zeige FGF17 ELISA Kits) and Fgf18 (zeige FGF18 ELISA Kits), to Cubn improves Fgf ligand endocytosis and availability to FgfRs, thus modulating Fgf signaling activity.
Impaired protein endocytosis caused by invalidation of ClC-5 (zeige CLCN5 ELISA Kits) primarily reflects a trafficking defect of megalin (zeige LRP2 ELISA Kits) and cubilin in PTC (zeige PTCH1 ELISA Kits).
Cubilin expression is pronounced in the extraembryonic visceral endoderm of embryos. Cubilin, is also expressed by a subpopulation of cells dispersed within the embryonic endoderm having a migratory morphology.
Amn (zeige TRAF3 ELISA Kits) is an essential component of the Cubn receptor complex
Cubilin is required for embryonic development and is essential for the formation of somites, and definitive endoderm.
Inactivation of RFC1 (zeige RFC1 ELISA Kits) impacts the expression of several ligands and interacting proteins in the cubilin-amnionless (zeige AMN ELISA Kits)-megalin (zeige LRP2 ELISA Kits) complex that are involved in the maternal-fetal transport of folate and other nutrients.
Study identified CUBN as a marker for risk stratification of patients with renal cell carcinoma (RCC (zeige XRCC1 ELISA Kits)). Lack of CUBN expression was significantly associated with early disease progression and poor patient outcome, independent of T-stage, Fuhrman grade and nodal status. Owing to a highly RCC (zeige XRCC1 ELISA Kits)-specific expression profile, CUBN expression also has a potential role in clinical cancer differential diagnostics.
CUBN SNP rs1801239 (I2984V), previously associated with albuminuria, was significantly associated with T2D-ESRD in blacks.
Tumoral expression of cubilin is a positive predictive marker for treatment of metastatic renal cell cancer patients with sunitinib and sorafenib.
The CUBN haplotypes were associated with an altered gastric cancer risk.
CUBN was associated with albuminuria in type 2 diabetes patients.
The variant rs11254363 of the CUBN gene was associated with a decreased risk of developing congenital heart disease in Han Chinese populations
MA is associated with CVD irrespective of the presence of the CUBN risk allele. These results challenge the concept that albuminuria in the setting of this mutation is benign.
Cubilin haploinsufficiency leads to reduced renal proximal tubular uptake of albumin (zeige ALB ELISA Kits) and apolipoprotein (apo)A (zeige APOA ELISA Kits)-I, significantly increasing urinary loss of albumin (zeige ALB ELISA Kits) and apoA-I (zeige APOA1 ELISA Kits).
predisposition to multibacillary leprosy in Vietnam is associated with CUBN and NEBL (zeige NEBL ELISA Kits) common variants in the chromosome 10p13 linkage region
LOS treatment decreased microalbuminuria induced by Cd apparently through a cubilin receptor-dependent mechanism but independent of megalin (zeige LRP2 ELISA Kits).
Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia.
cubilin (intrinsic factor-cobalamin receptor)
, 460 kDa receptor
, glycoprotein 280
, intrinsic factor-cobalamin receptor
, intrinsic factor-vitamin B12 receptor
, cubilin precursor variant 1
, cubilin precursor variant 2
, intestinal intrinsic factor receptor