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anti-Human YAP1 Antikörper:
anti-Mouse (Murine) YAP1 Antikörper:
anti-Rat (Rattus) YAP1 Antikörper:
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Human Monoclonal YAP1 Primary Antibody für IF, IHC (p) - ABIN564526
Lau, Murray, Houshmandi, Xu, Gutmann, Yu: Merlin is a potent inhibitor of glioma growth. in Cancer research 2008
Show all 17 Pubmed References
Human Polyclonal YAP1 Primary Antibody für ChIP, ICC - ABIN258559
Kapoor, Yao, Ying, Hua, Liewen, Wang, Zhong, Wu, Sadanandam, Hu, Chang, Chu, Al-Khalil, Jiang, Xia, Fletcher-Sananikone, Lim, Horwitz, Viale, Pettazzoni, Sanchez, Wang, Protopopov, Zhang, Heffernan et al.: Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer. ... in Cell 2014
Show all 12 Pubmed References
Human Monoclonal YAP1 Primary Antibody für FACS, IHC - ABIN969574
Fernandez-L, Northcott, Dalton, Fraga, Ellison, Angers, Taylor, Kenney: YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation. in Genes & development 2009
Show all 2 Pubmed References
Dog (Canine) Polyclonal YAP1 Primary Antibody für ELISA, WB - ABIN4219868
Zender, Spector, Xue, Flemming, Cordon-Cardo, Silke, Fan, Luk, Wigler, Hannon, Mu, Lucito, Powers, Lowe: Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. in Cell 2006
Human Polyclonal YAP1 Primary Antibody für ICC, IF - ABIN4366489
Li, Lim, Chen, McCabe, Kim, Zhang, Mao: Spinal expression of Hippo signaling components YAP and TAZ following peripheral nerve injury in rats. in Brain research 2013
Human Polyclonal YAP1 Primary Antibody für IF (p), IHC (p) - ABIN701485
Li, Shang, Shu, Zhang, Ji, Sun, Li, Xie: gga-miR-375 plays a key role in tumorigenesis post subgroup J avian leukosis virus infection. in PLoS ONE 2014
Studies indicate that the transcriptional co-activators YAP and TAZ (zeige TAZ Antikörper) recently emerged as key mediators of the biological effects that are observed in response to extracellular matrix (ECM (zeige MMRN1 Antikörper)) elasticity and cell shape.
The authors propose that phosphorylation of Amot (zeige AMOT Antikörper)(S176) is a critical post-translational modification that suppresses YAP's ability to promote cell proliferation and tumorigenesis by altering the subcellular localization of an essential YAP co-factor.
YAP maintains human embryonic stem cells pluripotency by preventing WNT3 (zeige WNT3 Antikörper) expression in response to Activin (zeige Actbeta Antikörper), thereby blocking a direct route to embryonic cardiac mesoderm formation.
These results demonstrate a critical role of the activation of YAP/TAZ (zeige TAZ Antikörper) by disturbed flow in promoting atheroprone phenotypes and atherosclerotic lesion development.
the complex structure of YAP WW2 domain with a high-affinity peptide was modeled and examined in detail, which was then used to guide structure-based peptide optimization to obtain several strong domain binders.
Findings indicate that long-term exposure to IM results in dysregulation of stem cell renewal-regulatory Hippo (MST1 (zeige MST1 Antikörper)/2)/YAP signaling, and that inhibition of miR (zeige MLXIP Antikörper)-181a using a microRNA sponge inhibitor resulted in decreased transcription of SOX2 (zeige SOX2 Antikörper) and SALL4 (zeige SALL4 Antikörper).
miR (zeige MLXIP Antikörper)-138 may play a suppressive role in the growth and metastasis of non small cell lung cancer cells partly at least by targeting YAP1
our study is the first to indicate the potential role of YAP1 as a common modulator of resistance mechanisms in lung cancer
Our results indicate that YAP promotes erlotinib resistance in the erlotinib-sensitive non-small cell lung cancer cell line HCC827
These findings uncover a suppressive role of SYNPO2 (zeige SYNPO2 Antikörper) in triple-negative breast cancer (TNBC) metastasis via inhibition of YAP/TAZ (zeige TAZ Antikörper), and suggest that SYNPO2 (zeige SYNPO2 Antikörper) might provide a potential prognosis marker and novel therapeutic strategy.
Yap1 has a crucial role in controlling the limb regenerative capacity in Xenopus
Decrease in actin tension and YAP inactivation should be crucially involved in the cytotoxicity of ethanol on HL-1 (zeige ASGR1 Antikörper) cardiomyocytes.
The results of this study indicated that YAP regulates oligodendrocyte morphology and maturation in response to mechanical factors.
Study found that the extracellular matrix protein laminin-511 (zeige LAMA5 Antikörper) (LM511) promoted the survival and differentiation of dopaminergic neurons in the midbrain neurons. LM511 bound to integrin alpha3beta1 and activated the transcriptional cofactor YAP.
YAP accumulated in nuclei of mammary glands in ErbB2 (zeige ERBB2 Antikörper)/EGFR (zeige EGFR Antikörper)-transgenic mice, suggesting that EGFR (zeige EGFR Antikörper) signaling affects YAP in vivo similar to cell culture. ErbB2 (zeige ERBB2 Antikörper)/EGFR (zeige EGFR Antikörper)-transgenic mice develop mammary tumors in 7-8 months, but surprisingly, MaSCs from these mice did not form tumors when transplanted into host mice.
Therefore, YAP/TAZ (zeige TAZ Antikörper) are crucial for Schwann cells to myelinate developing nerve and to maintain myelinated nerve in adulthood.
Collectively, we have uncovered that AMOT (zeige AMOT Antikörper) acts as a YAP stimulator in high glucose level.
YAP1 enhanced cementoblast mineralization in vitro. YAP1 exerted its effect on the cementoblast partly by regulating the Smad (zeige SMAD1 Antikörper)-dependent BMP and Erk1/2 (zeige MAPK1/3 Antikörper) signaling pathways.
A crucial role for YAP and TAZ (zeige TAZ Antikörper) in the maintenance of the postnatal adrenal cortex.
v-Src (zeige SRC Antikörper) prevents nuclear exclusion of YAP through a decrease in the phosphorylation of YAP at Ser127 in multinucleated cells.
Dystrophin-glycoprotein complex component dystroglycan 1 (Dag1) directly binds to the Hippo pathway effector Yap to inhibit cardiomyocyte proliferation in mice
YAP activation is a hallmark of malignant brain tumours.
During vascular regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression.
that Yap1 entered the nucleus and promoted transcription in response to blood flow.
that Yap1 integrates the anabolic demands of tissue growth during development and tumorigenesis by reprogramming nitrogen metabolism to stimulate nucleotide biosynthesis
Amotl2a (zeige AMOTL2 Antikörper) function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 and the Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) effector Lef1 (zeige LEF1 Antikörper).
data reveals that Yap is required for pronephric duct integrity, maintenance of baso-lateral cell polarity, and ciliogenesis during zebrafish kidney development
Yap/Taz (zeige TAZ Antikörper)-Tead activity is necessary and sufficient for optic vesicle progenitors to adopt retinal pigment epithelium identity in zebrafish.
Yap is essential for fin regeneration and that its function is dependent on mechanical tension, conferred by a balancing act of cell density and cytoskeleton activity.
When transcriptional coactivators Yap and Taz (zeige TAZ Antikörper) were restricted from interacting with Tead transcription factors through expression of a dominant negative transgene, cardiac precursors failed to migrate completely to the midline.
Yap coordinately regulates cell proliferation and apoptosis and is required for dorsoventral axis formation, gastrulation, cardiogenesis, hematopoiesis, and somitogenesis.
The data suggest that TEAD relocation and/or YAP degradation following its phosphorylation down-regulates IFNT gene transcription after conceptus attachment to the uterine endometrium.
This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction.
65 kDa Yes-associated protein
, yes-associated protein 2
, yorkie homolog
, Yes-associated protein 1, 65kDa
, Yes-associated protein 1, 65 kD
, yes-associated protein, 65 kDa