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Human Polyclonal MAPK3 Primary Antibody für ICC, IHC (p) - ABIN3044377
Li, Zhu, Liu, Liu, Wang, Xiong, Shen, Hu, Zheng: ZFX knockdown inhibits growth and migration of non-small cell lung carcinoma cell line H1299. in International journal of clinical and experimental pathology 2013
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Human Polyclonal MAPK3 Primary Antibody für WB - ABIN1881527
Munshi, Wu, Mukhopadhyay, Ottaviano, Sassano, Koblinski, Platanias, Stack et al.: Differential regulation of membrane type 1-matrix metalloproteinase activity by ERK 1/2- and p38 MAPK-modulated tissue inhibitor of metalloproteinases 2 expression controls transforming growth ... in The Journal of biological chemistry 2004
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Chicken Monoclonal MAPK3 Primary Antibody für IF, IP - ABIN967952
Boulton, Cobb: Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies. in Cell regulation 1991
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Chicken Polyclonal MAPK3 Primary Antibody für ICC, FACS - ABIN361833
Boulton, Gregory, Cobb: Purification and properties of extracellular signal-regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase. in Biochemistry 1991
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Human Polyclonal MAPK3 Primary Antibody für IF (p), IHC (p) - ABIN744143
Zhao, Zhang, Liu, Zhang, Hao, Li, Chen, Shen, Tang, Min, Meng, Wang, Yi, Zhang: Hydrogen Sulfide and/or Ammonia Reduces Spermatozoa Motility through AMPK/AKT Related Pathways. in Scientific reports 2016
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Human Polyclonal MAPK3 Primary Antibody für WB - ABIN2801963
McLaughlin, Kumar, McDonnell, Van Horn, Lee, Livi, Young: Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase. in The Journal of biological chemistry 1996
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Mouse (Murine) Polyclonal MAPK3 Primary Antibody für IHC, WB - ABIN3020725
Fan, Zhang, Hu, Li, Zhang: Activation of AKT/ERK confers non-small cell lung cancer cells resistance to vinorelbine. in International journal of clinical and experimental pathology 2014
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Human Monoclonal MAPK3 Primary Antibody für IP, WB - ABIN967398
Rossomando, Payne, Weber, Sturgill: Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase. in Proceedings of the National Academy of Sciences of the United States of America 1989
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Human Polyclonal MAPK3 Primary Antibody für IHC (p) - ABIN2473492
: [Aleksandr Semenovich Iontov (on his 70th birthday)]. in Arkhiv anatomii, gistologii i émbriologii 1978
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Human Monoclonal MAPK3 Primary Antibody für WB - ABIN1539804
Lei, Chen, Huang, Wu, Lin, Lai: Proteomic analysis of the effect of extracellular calcium ions on human mesenchymal stem cells: Implications for bone tissue engineering. in Chemico-biological interactions 2015
results demonstrated that OEA exerts anti-inflammatory effects by enhancing PPARalpha (zeige PPARA Antikörper) signaling, inhibiting the TLR4 (zeige TLR4 Antikörper)-mediated NF-kappaB (zeige NFKB1 Antikörper) signaling pathway, and interfering with the ERK1/2-dependent signaling cascade (TLR4 (zeige TLR4 Antikörper)/ERK1/2/AP-1 (zeige FOSB Antikörper)/STAT3 (zeige STAT3 Antikörper)), which suggests that OEA may be a therapeutic agent for inflammatory diseases.
the physiological role of the negative crosstalk between the cAMP/PKA/AKAP4 and the PKC/ERK1/2 pathways is to regulate capacitation and acrosome reaction.
co-treatment with curcumin and cisplatin synergistically induces apoptosis through ROS-mediated activation of ERK1/2 in bladder cancer
ERK1/2 and p-ERK1/2 seem to be important in the development of Gallbladder cancer (GBC).
High p-ERK1/2 expression is an independent factor for poor prognosis in newly diagnosed patients with Multiple Myeloma
The observations identify a novel strategy of prostate cancer cell diapedesis, which depends on the activation of intercellular Cx43 (zeige GJA1 Antikörper)/ERK1/ERK2 (zeige MAPK1 Antikörper)/Cx43 (zeige GJA1 Antikörper) signaling axis at the interfaces between Cx43 (zeige GJA1 Antikörper)-high prostate cancer and endothelial cells.
thrombin (zeige F2 Antikörper) binding to PAR-1 (zeige MARK2 Antikörper) receptor activated Gi-protein/c (zeige PROC Antikörper)-Src (zeige SRC Antikörper)/Pyk2 (zeige PTK2B Antikörper)/EGFR (zeige EGFR Antikörper)/PI3K (zeige PIK3CA Antikörper)/Akt (zeige AKT1 Antikörper)/p42/p44 (zeige PSMC6 Antikörper) MAPK cascade, which in turn elicited AP-1 (zeige FOSB Antikörper) activation and ultimately evoked MMP-9 (zeige MMP9 Antikörper) expression and cell migration in SK-N-SH cells.
Apocynin may act as a novel molecular candidate to protect against vascular smooth muscle cell osteogenic switching/vascular calcification through suppressing ERK1/2 pathway.
GHRH agonist MR-409 increase phosphorylation of AKT and ERK1/2 in dermal fibroblasts.
telomere stability is under direct control of one of the major pro-oncogenic signaling pathways (RAS/RAF (zeige RAF1 Antikörper)/MEK (zeige MAP2K1 Antikörper)/ERK (zeige EPHB2 Antikörper)) via TRF2 (zeige TERF2 Antikörper) phosphorylation.
ERK1 and ERK2 (zeige MAPK1 Antikörper) play specific roles in beta cells. ERK2 (zeige MAPK1 Antikörper) cannot always compensate for the lack of ERK1 but the absence of a clear-cut phenotype in Erk1 (-/-) mice shows that ERK1 is dispensable in normal conditions.
The Macrophage Activation Induced by Bacillus thuringiensis Cry1Ac Protoxin Involves ERK1/2 and p38 (zeige CRK Antikörper) Pathways and the Interaction with Cell-Surface-HSP70 (zeige HSP70 Antikörper).
hBD-1 potentiates the induction of in vitro osteoclastogenesis by RANKL via enhanced phosphorylation of the p44/42 MAPKs.
ERK1 role in the osteoclast differentiation.Insulin induces RANK expression via ERK1/2, which contributes to the enhancement of osteoclast differentiation.
Suppressing P38 (zeige CRK Antikörper) promoted adipogenic trans-differentiation and intensified adipolytic metabolism in differentiated cells. However, inhibition of ERK1/2 had the opposite effects on adipogenesis and no effect on adipolysis. Blocking JNK (zeige MAPK8 Antikörper) weakly blocked trans-differentiation but stimulated adipolysis and induced apoptosis.
Taken together, the results of our present study indicated that DHCE could inhibit cellular proliferation and induce cell apoptosis in myeloma cells mediated through different mechanisms, possibly through inhibiting the IL-6/STAT3 and ERK1/2 pathways. And it may provide a new therapeutic option for MM patients.
Betacellulin (zeige BTC Antikörper) promotes the proliferation of corneal epithelial stem cells through the phosphorylation of Erk1/Erk2 (zeige MAPK1 Antikörper).
North American ginseng inhibits myocardial NOX2 (zeige CYBB Antikörper)-ERK1/2-TNF-alpha (zeige TNF Antikörper) signaling pathway and improves cardiac function in endotoxemia, suggesting that NA ginseng may have the potential in the prevention of clinical sepsis.
NF-alpha1 is critical for regulating antiproliferation and cell fate determination, through differentiating embryonic stem cells to GFAP (zeige GFAP Antikörper)-positive astrocytes for normal neurodevelopment.
These findings suggested that USP14 induces NF-kappaB activity and ERK1/2 phosphorylation triggered by microbial infection.
ERK1/2-Akt1 (zeige AKT1 Antikörper) crosstalk regulates arteriogenesis in mice and zebrafish.
eena (zeige SH3GL1 Antikörper) plays an important role in the development of the myeloid cell through activation of the ERK1/ERK2 (zeige MAPK1 Antikörper) pathway
ERK1 and ERK2 (zeige MAPK1 Antikörper) target common and distinct gene sets, confirming diverse roles for these kinases during embryogenesis; for ERK1 different specific genes involved in dorsal-ventral patterning and subsequent embryonic cell migration were identified.
These results demonstrate that induction of Hsp70 (zeige HSPA1A Antikörper) in response to heat stress is dependent on ERK (zeige MAPK1 Antikörper) activation in Pac2 (zeige PSMG2 Antikörper) cells.
Data define distinct roles for ERK1 and ERK2 (zeige MAPK1 Antikörper) in developmental cell migration processes during zebrafish embryogenesis.
MAPK3/1 is involved in luteinizing hormone-mediated decrease of C-type natriuretic peptide and this process is related to the EGFR (zeige EGFR Antikörper) and MAPK3/1 signal pathways
Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.
ER Ca(2+) release enhances eNOS Ser-635 phosphorylation and function via ERK1/2 activation.
Thrombospondin 1 (zeige THBS1 Antikörper), fibronectin (zeige FN1 Antikörper), and vitronectin (zeige VTN Antikörper) are differentially dependent upon RAS, ERK1/2, and p38 (zeige MAPK14 Antikörper) for induction of vascular smooth muscle cell chemotaxis.
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
These data suggest that Gab1-ERK1/2 binding and their nuclear translocation play a crucial role in Egr-1 (zeige EGR1 Antikörper) nuclear accumulation.
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
This study demonstrates for the first time that cyclic mechanical stretch induces the proliferation of bovine satellite cells and suppresses their myogenic differentiation through the activation of ERK (zeige MAPK1 Antikörper).
findings indicate that exposure to DHEA, at concentrations found in human blood, causes vascular endothelial proliferation by a plasma membrane-initiated activity that is Gi/o and ERK1/2 dependent.
Results suggest that estrogen receptors and the ERK1/2 signaling pathway are involved in the anti-apoptotic action of LY117018 in vascular endothelial cells.
Early activation of MAPK p44/42 is involved in deoxynivalenol -induced disruption of intestinal barrier function and tight junction network signaling.
Pseudorabies virus glycoprotein gE-mediated ERK 1/2 phosphorylation also occurs in epithelial cells and in these cells, gE-mediated ERK 1/2 signaling is associated with degradation of the pro-apoptotic protein Bim (zeige BCL2L11 Antikörper).
Treatment with ERK inhibitors or ERK1/2 knockdown significantly suppressed porcine epidemic diarrhea virus progeny production.
This study reveals a new function of the gE glycoprotein of pseudorabies virus and suggests that pseudorabies virus, through activation of ERK1/2 signaling, has a substantial impact on T cell behavior.
CSF2 (zeige CSF2 Antikörper) stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 MAPK (zeige MAPK1 Antikörper)-dependent MTOR (zeige FRAP1 Antikörper) signal transduction cascades.
PGRN (zeige GRN Antikörper) inhibits adipogenesis in porcine preadipocytes partially through ERK (zeige MAPK1 Antikörper) activation mediated PPARgamma (zeige PPARG Antikörper) phosphorylation.
Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK (zeige PRKAA1 Antikörper)/ERK (zeige MAPK1 Antikörper)/TSC2 (zeige TSC2 Antikörper)/mTOR (zeige FRAP1 Antikörper) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis
Data show that proinflammatory cytokines induction was ERK1/2 and JNK1 (zeige MAPK8 Antikörper)/2 dependent.
Saccharomyces cerevisiae inhibits the Enterotoxigenic Escherichia coli-induced expression of pro-inflammatory transcripts and this inhibition was associated to a decrease of ERK1/2 and p38 MAPK (zeige MAPK14 Antikörper) phosphorylation
ERK1 phosphorylation in response to Insulin-like Growth Factor-1 (zeige IGF1 Antikörper) does not require activation of the Insulin-like Growth Factor-1 receptor tyrosine kinase (zeige IGF1R Antikörper)
The results suggest that the MPK-1 (zeige MAPK1 Antikörper)/ERK (zeige MAPK1 Antikörper) regulatory network, including FBF-1 (zeige FBF1 Antikörper), FBF-2, and LIP-1 (zeige CENPJ Antikörper), controls the number of sperm by regulating the timing of the sperm-oocyte switch in C. elegans.
Cek2 (zeige FGFR3 Antikörper) has a cryptic role in cell-wall biogenesis and its role is not entirely redundant to Cek1.
knockdown of SUV420H1 (zeige SUV420H1 Antikörper) reduced phosphorylated ERK1 and total ERK1 proteins, and interestingly suppressed ERK1 at the transcriptional level
Secreted aspartic protease-mediated proteolytic cleavage of Msb2 is required for activation of the Cek1 mitogen activated protein kinase (zeige MAPK1 Antikörper) pathway in response to environmental cues.
The authors propose that a Msb2, Cek1 and Ace2 signalling pathway addresses PMT genes as downstream targets and that different modes of regulation have evolved for PMT1 and PMT2/PMT4 genes.
Msb2 is involved in the transmission of the signal toward Cek1 mediated by the Cdc42 (zeige CDC42 Antikörper) GTPase (zeige RACGAP1 Antikörper).
abscisic acid and jasmonate mediate inactivation of the immune-associated MAP kinases (MAPKs), MPK3 and MPK6 (zeige MAPK6 Antikörper), in Arabidopsis thaliana ABA induced expression of genes encoding the protein phosphatases 2C (PP2Cs), HAI1 (zeige SPINT1 Antikörper), HAI2 (zeige SPINT2 Antikörper), and HAI3 through ABF/AREB transcription factors
Constitutive active-MPK3 plants are more resistant to the hemibiotrophic pathogen Pseudomonas syringae DC3000.
constitutively active (CA)-MPK3 crosses with summ1 and summ2, two known suppressors of mpk4 (zeige MAPK4 Antikörper), resulted in a partial reversion of the CA-MPK3 phenotypes.
that MPK3/MPK6 (zeige MAPK6 Antikörper) phosphorylate and destabilize ICE1, which negatively regulates CBF (zeige CEBPZ Antikörper) expression and freezing tolerance in plants
Changes in PUB22 Ubiquitination Modes Triggered by MITOGEN-ACTIVATED PROTEIN KINASE3 Dampen the Immune Response
MPK3 role in ultraviolet induced stomatal closure
Study propose that the pathogen-responsive MPK3/MPK6 (zeige MAPK6 Antikörper) cascade and ABA are two essential signaling pathways that control, respectively, the organic acid metabolism and ion channels, two main branches of osmotic regulation in guard cells that function interdependently to control stomatal opening/closure.
Data report that MPK3/MPK6 and their substrate ERF6 promote the biosynthesis of IGSs and the conversion of I3G to 4MI3G, a target of PEN2/PEN3-dependent chemical defenses in plant immunity.
Data show that the protein kinases MPK3 and MPK6 (zeige MAPK6 Antikörper) can both interact with SPOROCYTELESS/NOZZLE (SPL (zeige SGPL1 Antikörper)) in vitro and in vivo and can phosphorylate the SPL (zeige SGPL1 Antikörper) protein in vitro.
MKK4 (zeige MAP2K4 Antikörper), MKK5 (zeige MAP2K5 Antikörper), MKK7 (zeige MAP2K7 Antikörper), and MKK9, are responsible for the activation of MPK3 and MPK6 (zeige MAPK6 Antikörper) by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK (zeige MAPK1 Antikörper) signaling through MKK4 (zeige MAP2K4 Antikörper)/5/7/9-MPK3/6 cascades.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.
MAP kinase isoform p44
, MAPK 1
, extracellular signal-regulated kinase 1
, extracellular signal-related kinase 1
, insulin-stimulated MAP2 kinase
, microtubule-associated protein 2 kinase
, MAP kinase 3
, p44 MAP kinase
, pp42/MAP kinase
, mitogen-activated protein kinase 3
, MAP kinase 12
, MAPK 12
, extracellular signal-regulated kinase 6
, mitogen-activated protein kinase 12
, stress-activated protein kinase 3
, MAP kinase 1
, MAPK 3
, mitogen-activated 3
, mitogen-activated protein kinase 1
, extracellular signal-regulated kinase-1
, likely protein kinase