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anti-Human MAPK3 Antikörper:
anti-Mouse (Murine) MAPK3 Antikörper:
anti-Rat (Rattus) MAPK3 Antikörper:
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Human Polyclonal MAPK3 Primary Antibody für ICC, IHC (p) - ABIN3044377
Li, Zhu, Liu, Liu, Wang, Xiong, Shen, Hu, Zheng: ZFX knockdown inhibits growth and migration of non-small cell lung carcinoma cell line H1299. in International journal of clinical and experimental pathology 2013
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Human Polyclonal MAPK3 Primary Antibody für WB - ABIN1881527
Munshi, Wu, Mukhopadhyay, Ottaviano, Sassano, Koblinski, Platanias, Stack et al.: Differential regulation of membrane type 1-matrix metalloproteinase activity by ERK 1/2- and p38 MAPK-modulated tissue inhibitor of metalloproteinases 2 expression controls transforming growth ... in The Journal of biological chemistry 2004
Show all 6 Pubmed References
Chicken Monoclonal MAPK3 Primary Antibody für IF, IP - ABIN967952
Boulton, Cobb: Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies. in Cell regulation 1991
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Chicken Polyclonal MAPK3 Primary Antibody für ICC, FACS - ABIN361833
Boulton, Gregory, Cobb: Purification and properties of extracellular signal-regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase. in Biochemistry 1991
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Human Polyclonal MAPK3 Primary Antibody für IF (p), IHC (p) - ABIN744143
Zhao, Zhang, Liu, Zhang, Hao, Li, Chen, Shen, Tang, Min, Meng, Wang, Yi, Zhang: Hydrogen Sulfide and/or Ammonia Reduces Spermatozoa Motility through AMPK/AKT Related Pathways. in Scientific reports 2016
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Human Polyclonal MAPK3 Primary Antibody für WB - ABIN2801963
McLaughlin, Kumar, McDonnell, Van Horn, Lee, Livi, Young: Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase. in The Journal of biological chemistry 1996
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Mouse (Murine) Polyclonal MAPK3 Primary Antibody für IHC, WB - ABIN3020725
Fan, Zhang, Hu, Li, Zhang: Activation of AKT/ERK confers non-small cell lung cancer cells resistance to vinorelbine. in International journal of clinical and experimental pathology 2014
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Human Polyclonal MAPK3 Primary Antibody für IHC (p), IHC - ABIN152967
Nymoen, Hetland Falkenthal, Holth, Ow, Ivshina, Tropé, Kuznetsov, Staff, Davidson: Expression and clinical role of chemoresponse-associated genes in ovarian serous carcinoma. in Gynecologic oncology 2015
Human Polyclonal MAPK3 Primary Antibody für IHC (p) - ABIN2473492
: [Aleksandr Semenovich Iontov (on his 70th birthday)]. in Arkhiv anatomii, gistologii i émbriologii 1978
Show all 2 Pubmed References
Human Monoclonal MAPK3 Primary Antibody für ICC, FACS - ABIN969277
Karreth, DeNicola, Winter, Tuveson: C-Raf inhibits MAPK activation and transformation by B-Raf(V600E). in Molecular cell 2009
High ERK1 expression is associated with gastric cancer.
Data suggest that Thr264 in TRPV3 (zeige TRPV3 Antikörper) is key ERK1 phosphorylation site mediating EGFR (zeige EGFR Antikörper)-induced sensitization of TRPV3 (zeige TRPV3 Antikörper) to stimulate signaling pathways involved in regulating skin homeostasis. (TRPV3 (zeige TRPV3 Antikörper) = transient receptor potential cation channel subfamily V member-3 (zeige TRPV3 Antikörper); ERK1 = extracellular signal-regulated kinase-1; EGFR (zeige EGFR Antikörper) = epidermal growth factor receptor (zeige EGFR Antikörper))
Role for ERK1/2-dependent activation of FCHSD2 in cancer cell-selective regulation of clathrin-mediated endocytosis.
These results demonstrate that betaine acts through ERK1/2-PPARgamma (zeige PPARG Antikörper) signalling pathway to regulate lipid metabolism in adipogenic-differentiated skeletal muscle cells, which could provide some useful information for controlling muscle lipid accumulation by manipulating ERK1/2 and PPARgamma (zeige PPARG Antikörper) signalling pathway.
The present study demonstrated that the downregulation of filaggrin (zeige FLG Antikörper) in the epidermis by toluene is mediated by ERK1/2 and STAT3 (zeige STAT3 Antikörper)-dependent pathways.
RASSF7 promotes cell proliferation through activating MEK1 (zeige MAP2K1 Antikörper)/MEK2 (zeige MAP2K2 Antikörper)-ERK1/ERK2 (zeige MAPK1 Antikörper) signaling pathway in hepatocellular carcinoma.
SHP-2 (zeige PTPN11 Antikörper) may augment the ERK1/2 activity and cell proliferation activity in IL-21 (zeige IL17C Antikörper) signaling.
intact keratin filaments are regulators for PKB/Akt (zeige AKT1 Antikörper) and p44 (zeige GTF2H2 Antikörper)/42 activity, basal and in response to stretch.
Immune profiling of human prostate epithelial cells in health and pathology determined by expression of p38 (zeige CRK Antikörper)/TRAF-6 (zeige TRAF6 Antikörper)/ERK (zeige EPHB2 Antikörper) MAP kinases pathways has been reported.
Integrated ERK1/ERK2 (zeige MAPK1 Antikörper) response to B (zeige TDO2 Antikörper)-cell receptor stimulation and SF3B1 (zeige SF3B2 Antikörper) gene mutations refine prognosis in chronic lymphocytic leukemia.
M-CSF (zeige CSF1R Antikörper)-evoked ERK1/2 activation was decreased, whereas AKT (zeige AKT1 Antikörper) activation was enhanced in SHP2 (zeige PTPN11 Antikörper)-deficient BMMs. ERK1/2, via its downstream target RSK2 (zeige RPS6KA3 Antikörper), mediates this negative feedback by negatively regulating phosphorylation of M-CSF (zeige CSF1R Antikörper) receptor at Tyr721 and, consequently, its binding to p85 (zeige ECM1 Antikörper) subunit of PI3K and PI3K activation.
Low ERK1 Phosphorylation is associated with low liver regeneration.
ERK5 provides a common bypass route in intestinal epithelial cells, which rescues cell proliferation upon abrogation of ERK1/2 signalling, with therapeutic implications in colorectal cancer.
In a retinitis pigmentosa mouse model, TrkC (zeige NTRK3 Antikörper) activity generates phosphorylated Erk (zeige EPHB2 Antikörper), which upregulates glial TNF-alpha (zeige TNF Antikörper), causing selective neuronal death.
A. fumigatus increased PAR-2 expression and elevated disease, PMN infiltration, and proinflammatory cytokine expreERK1 Kinasession through PAR-2, which may be modified by p-ERK1/2.
ERK1 and ERK2 (zeige MAPK1 Antikörper) play specific roles in beta cells. ERK2 (zeige MAPK1 Antikörper) cannot always compensate for the lack of ERK1 but the absence of a clear-cut phenotype in Erk1 (-/-) mice shows that ERK1 is dispensable in normal conditions.
The Macrophage Activation Induced by Bacillus thuringiensis Cry1Ac Protoxin Involves ERK1/2 and p38 (zeige CRK Antikörper) Pathways and the Interaction with Cell-Surface-HSP70 (zeige HSP70 Antikörper).
hBD-1 potentiates the induction of in vitro osteoclastogenesis by RANKL via enhanced phosphorylation of the p44/42 MAPKs.
ERK1 role in the osteoclast differentiation.Insulin induces RANK expression via ERK1/2, which contributes to the enhancement of osteoclast differentiation.
Suppressing P38 (zeige CRK Antikörper) promoted adipogenic trans-differentiation and intensified adipolytic metabolism in differentiated cells. However, inhibition of ERK1/2 had the opposite effects on adipogenesis and no effect on adipolysis. Blocking JNK (zeige MAPK8 Antikörper) weakly blocked trans-differentiation but stimulated adipolysis and induced apoptosis.
MAPK3 role in the oocyte maturation
ERK1/2-Akt1 (zeige AKT1 Antikörper) crosstalk regulates arteriogenesis in mice and zebrafish.
eena (zeige SH3GL1 Antikörper) plays an important role in the development of the myeloid cell through activation of the ERK1/ERK2 (zeige MAPK1 Antikörper) pathway
ERK1 and ERK2 (zeige MAPK1 Antikörper) target common and distinct gene sets, confirming diverse roles for these kinases during embryogenesis; for ERK1 different specific genes involved in dorsal-ventral patterning and subsequent embryonic cell migration were identified.
These results demonstrate that induction of Hsp70 (zeige HSPA1A Antikörper) in response to heat stress is dependent on ERK (zeige MAPK1 Antikörper) activation in Pac2 (zeige PSMG2 Antikörper) cells.
Data define distinct roles for ERK1 and ERK2 (zeige MAPK1 Antikörper) in developmental cell migration processes during zebrafish embryogenesis.
MAPK3/1 is involved in luteinizing hormone-mediated decrease of C-type natriuretic peptide and this process is related to the EGFR (zeige EGFR Antikörper) and MAPK3/1 signal pathways
Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.
ER Ca(2+) release enhances eNOS Ser-635 phosphorylation and function via ERK1/2 activation.
Thrombospondin 1 (zeige THBS1 Antikörper), fibronectin (zeige FN1 Antikörper), and vitronectin (zeige VTN Antikörper) are differentially dependent upon RAS, ERK1/2, and p38 (zeige MAPK14 Antikörper) for induction of vascular smooth muscle cell chemotaxis.
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
These data suggest that Gab1-ERK1/2 binding and their nuclear translocation play a crucial role in Egr-1 (zeige EGR1 Antikörper) nuclear accumulation.
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
This study demonstrates for the first time that cyclic mechanical stretch induces the proliferation of bovine satellite cells and suppresses their myogenic differentiation through the activation of ERK (zeige MAPK1 Antikörper).
findings indicate that exposure to DHEA, at concentrations found in human blood, causes vascular endothelial proliferation by a plasma membrane-initiated activity that is Gi/o and ERK1/2 dependent.
Results suggest that estrogen receptors and the ERK1/2 signaling pathway are involved in the anti-apoptotic action of LY117018 in vascular endothelial cells.
Early activation of MAPK p44/42 is involved in deoxynivalenol -induced disruption of intestinal barrier function and tight junction network signaling.
Pseudorabies virus glycoprotein gE-mediated ERK 1/2 phosphorylation also occurs in epithelial cells and in these cells, gE-mediated ERK 1/2 signaling is associated with degradation of the pro-apoptotic protein Bim (zeige BCL2L11 Antikörper).
Treatment with ERK inhibitors or ERK1/2 knockdown significantly suppressed porcine epidemic diarrhea virus progeny production.
This study reveals a new function of the gE glycoprotein of pseudorabies virus and suggests that pseudorabies virus, through activation of ERK1/2 signaling, has a substantial impact on T cell behavior.
CSF2 (zeige CSF2 Antikörper) stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 MAPK (zeige MAPK1 Antikörper)-dependent MTOR (zeige FRAP1 Antikörper) signal transduction cascades.
PGRN (zeige GRN Antikörper) inhibits adipogenesis in porcine preadipocytes partially through ERK (zeige MAPK1 Antikörper) activation mediated PPARgamma (zeige PPARG Antikörper) phosphorylation.
Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK (zeige PRKAA1 Antikörper)/ERK (zeige MAPK1 Antikörper)/TSC2 (zeige TSC2 Antikörper)/mTOR (zeige FRAP1 Antikörper) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis
Data show that proinflammatory cytokines induction was ERK1/2 and JNK1 (zeige MAPK8 Antikörper)/2 dependent.
Saccharomyces cerevisiae inhibits the Enterotoxigenic Escherichia coli-induced expression of pro-inflammatory transcripts and this inhibition was associated to a decrease of ERK1/2 and p38 MAPK (zeige MAPK14 Antikörper) phosphorylation
ERK1 phosphorylation in response to Insulin-like Growth Factor-1 (zeige IGF1 Antikörper) does not require activation of the Insulin-like Growth Factor-1 receptor tyrosine kinase (zeige IGF1R Antikörper)
The results suggest that the MPK-1 (zeige MAPK1 Antikörper)/ERK (zeige MAPK1 Antikörper) regulatory network, including FBF-1 (zeige FBF1 Antikörper), FBF-2, and LIP-1 (zeige CENPJ Antikörper), controls the number of sperm by regulating the timing of the sperm-oocyte switch in C. elegans.
Cek2 (zeige FGFR3 Antikörper) has a cryptic role in cell-wall biogenesis and its role is not entirely redundant to Cek1.
knockdown of SUV420H1 (zeige SUV420H1 Antikörper) reduced phosphorylated ERK1 and total ERK1 proteins, and interestingly suppressed ERK1 at the transcriptional level
Secreted aspartic protease-mediated proteolytic cleavage of Msb2 is required for activation of the Cek1 mitogen activated protein kinase (zeige MAPK1 Antikörper) pathway in response to environmental cues.
The authors propose that a Msb2, Cek1 and Ace2 signalling pathway addresses PMT genes as downstream targets and that different modes of regulation have evolved for PMT1 and PMT2/PMT4 genes.
Msb2 is involved in the transmission of the signal toward Cek1 mediated by the Cdc42 (zeige CDC42 Antikörper) GTPase (zeige RACGAP1 Antikörper).
abscisic acid and jasmonate mediate inactivation of the immune-associated MAP kinases (MAPKs), MPK3 and MPK6 (zeige MAPK6 Antikörper), in Arabidopsis thaliana ABA induced expression of genes encoding the protein phosphatases 2C (PP2Cs), HAI1 (zeige SPINT1 Antikörper), HAI2 (zeige SPINT2 Antikörper), and HAI3 through ABF/AREB transcription factors
Constitutive active-MPK3 plants are more resistant to the hemibiotrophic pathogen Pseudomonas syringae DC3000.
constitutively active (CA)-MPK3 crosses with summ1 and summ2, two known suppressors of mpk4 (zeige MAPK4 Antikörper), resulted in a partial reversion of the CA-MPK3 phenotypes.
that MPK3/MPK6 (zeige MAPK6 Antikörper) phosphorylate and destabilize ICE1, which negatively regulates CBF (zeige CEBPZ Antikörper) expression and freezing tolerance in plants
Changes in PUB22 Ubiquitination Modes Triggered by MITOGEN-ACTIVATED PROTEIN KINASE3 Dampen the Immune Response
MPK3 role in ultraviolet induced stomatal closure
Study propose that the pathogen-responsive MPK3/MPK6 (zeige MAPK6 Antikörper) cascade and ABA are two essential signaling pathways that control, respectively, the organic acid metabolism and ion channels, two main branches of osmotic regulation in guard cells that function interdependently to control stomatal opening/closure.
Data report that MPK3/MPK6 and their substrate ERF6 promote the biosynthesis of IGSs and the conversion of I3G to 4MI3G, a target of PEN2/PEN3-dependent chemical defenses in plant immunity.
Data show that the protein kinases MPK3 and MPK6 (zeige MAPK6 Antikörper) can both interact with SPOROCYTELESS/NOZZLE (SPL (zeige SGPL1 Antikörper)) in vitro and in vivo and can phosphorylate the SPL (zeige SGPL1 Antikörper) protein in vitro.
MKK4 (zeige MAP2K4 Antikörper), MKK5 (zeige MAP2K5 Antikörper), MKK7 (zeige MAP2K7 Antikörper), and MKK9, are responsible for the activation of MPK3 and MPK6 (zeige MAPK6 Antikörper) by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK (zeige MAPK1 Antikörper) signaling through MKK4 (zeige MAP2K4 Antikörper)/5/7/9-MPK3/6 cascades.
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.
MAP kinase isoform p44
, MAPK 1
, extracellular signal-regulated kinase 1
, extracellular signal-related kinase 1
, insulin-stimulated MAP2 kinase
, microtubule-associated protein 2 kinase
, MAP kinase 3
, p44 MAP kinase
, pp42/MAP kinase
, mitogen-activated protein kinase 3
, MAP kinase 1
, MAPK 3
, mitogen-activated 3
, mitogen-activated protein kinase 1
, extracellular signal-regulated kinase-1
, likely protein kinase