anti-MAP2K2 (MAP2K2) Antikörper

Human Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) Interaktionspartner

1. Data show that SAM and SH3 domain containing 1 (zeige SASH1 Antikörper) protein (SASH1 (zeige SASH1 Antikörper)) binds with mitogen-activated protein kinase kinase 2 (MAP2K2), and SASH1 (zeige SASH1 Antikörper) mutations promote binding between SASH1 (zeige SASH1 Antikörper) and MAP2K2.

2. findings demonstrate the interaction of tRNA with MEK2 in pancreatic cancer cells and suggest that tRNA may impact MEK2 activity in cancer cells

3. Report a synthetic lethal interaction of cetuximab in combination with MEK1 (zeige MAP2K1 Antikörper)/2 inhibition for the NRAS (zeige NRAS Antikörper) mutant subgroup of metastatic colorectal cancer.

4. There are no other biomarkers correlated with treatment responses following MEK1 (zeige MAP2K1 Antikörper)/2 inhibition.

5. MEK2 was essential for the phosphorylation of MKK3 (zeige MAP2K3 Antikörper)/MKK6 (zeige MAP2K6 Antikörper) and p38 MAPK (zeige MAPK14 Antikörper) that directly impacted on cyclin D1 (zeige CCND1 Antikörper) expression.

6. High MEK2 expression is associated with inflammation.

7. there were significant decreases in intercellular adhesion molecules 1 (ICAM1 (zeige ICAM1 Antikörper)), ezrin (EZR (zeige EZR Antikörper)), mitogen-activated protein kinase kinase 2 (MAP2K2), and nitric oxide synthase (zeige NOS Antikörper) 3 (NOS3 (zeige NANOS3 Antikörper)) gene expressions in metabolic syndrome patients.

8. The patient showed a paternally inherited 16p13.11 microduplication and a de novo 19p13.3 microdeletion involving the mitogen-activated protein kinase kinase 2 gene (MAP2K2), in which mutations cause the cardio-facio-cutaneous (CFC (zeige PTPN11 Antikörper)) syndrome

9. Data show that mitogen-activated protein kinase (zeige MAPK1 Antikörper) kinases MEK1 (zeige MAP2K1 Antikörper)/2 inhibitor pimasertib (MEKI) sensitized the cells to apoptosis through its ability to promote a G1 cell cycle arrest.

10. the purpose of this paper was to investigate MAPK (zeige MAPK1 Antikörper) downstream signalling molecules in Natural killer cell phenotypes from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients.

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) Interaktionspartner

1. data suggest that, although short-term suppression of Mek1 (zeige MAP2K1 Antikörper)/2 in ES cells helps to maintain an inner cell mass-like epigenetic state, prolonged suppression results in irreversible changes that compromise their developmental potential

2. Erk5 (zeige MAPK7 Antikörper) MAP kinase (zeige MAPK1 Antikörper) is activated in response to PDGF (zeige PDGFA Antikörper)-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2 (zeige MAP3K2 Antikörper), Mek1 (zeige MAP2K1 Antikörper)/2, Mek5 (zeige MAP2K5 Antikörper), PI3-kinase (zeige PIK3CA Antikörper) and protein kinase C (PKC (zeige PKC Antikörper)).

3. fluid shear stress induces autocrine TGF-beta (zeige TGFB1 Antikörper)/ALK5 (zeige TGFBR1 Antikörper)-induced target gene expression in renal epithelial cells, which is partially restrained by MEK1 (zeige MAP2K1 Antikörper)/2-mediated signaling.

4. FGF2 (zeige FGF2 Antikörper) is an extracellular inducer of COUP-TFII (zeige NR2F2 Antikörper) expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII (zeige NR2F2 Antikörper) expression prior to the onset of osteogenic differentiation

5. REDD1 (zeige DDIT4 Antikörper) is required for normal insulin (zeige INS Antikörper)-stimulated signaling, and a subtle balance exists between MEK1 (zeige MAP2K1 Antikörper)/2, REDD1 (zeige DDIT4 Antikörper), and mTOR (zeige FRAP1 Antikörper)

6. MEK1 (zeige MAP2K1 Antikörper) and MEK2 can substitute for each other but a minimum amount of MEK (zeige MDK Antikörper) is critical for placenta development and embryo survival

7. MK2 (zeige KCNA2 Antikörper)/3 cascade plays a strategic role in controlling synaptic plasticity and cognition.

8. MK2 (zeige KCNA2 Antikörper) attenuates dendritic cell-mediated Th1 (zeige HAND1 Antikörper) differentiation and autoimmune encephalomyelitis.

9. analysis of p38 (zeige CRK Antikörper)-MK2 (zeige KCNA2 Antikörper)-activated Rsk (zeige RPS6KA1 Antikörper) signaling in toll (zeige TLR4 Antikörper)-like receptor-stimulated dendritic cells

10. both MEK1 (zeige MAP2K1 Antikörper) and MEK2 have crucial roles in the integration of mesenchymal and epithelial signals essential for the development of the entire respiratory tract

Arabidopsis thaliana Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) Interaktionspartner

1. the AtMKK2-AtMPK10 (zeige MAPK10 Antikörper) MAPK (zeige MAPK1 Antikörper) module regulates leaf venation complexity by altering polar auxin transport efficiency

2. Treatment of Arabidopsis with a membrane rigidifier, DMSO, causes MPK4 (zeige MAPK4 Antikörper) activation concomitantly with MEKK1 (zeige MAP3K1 Antikörper) and MKK2 phosphorylation.

3. Ca(2 (zeige CA2 Antikörper)+) signaling occurred upstream of the MEKK1 (zeige MAP3K1 Antikörper)-MKK2 pathway. MEKK1 (zeige MAP3K1 Antikörper) was phosphorylated by calcium/calmodulin-regulated receptor-like kinase (CRLK1), which suggested that CRLK1 is one of candidates located upstream of MEKK1 (zeige MAP3K1 Antikörper).

4. Data indicate that MEKK2 (zeige MAP3K2 Antikörper) is required for the mekk1 (zeige MAP3K1 Antikörper), mkk1 (zeige MAP2K1 Antikörper) mkk2, and mpk4 (zeige MAPK4 Antikörper) autoimmune phenotypes.

5. Data suggest that the MEKK1 (zeige MAP3K1 Antikörper)-MKK1 (zeige MAP2K1 Antikörper)/MKK2-MPK4 (zeige MAPK4 Antikörper) kinase cascade negatively regulates MEKK2 (zeige MAP3K2 Antikörper) and activation of MEKK2 (zeige MAP3K2 Antikörper) triggers SUMM2-mediated immune responses.

6. Data indicate that MKK2 plays a role in abiotic stress tolerance and plant disease resistance.

7. double loss-of-function mutant (mkk1 (zeige MAP2K1 Antikörper)/2) of MKK1 (zeige MAP2K1 Antikörper) and MKK2 is shown to have marked phenotypes in development and disease

8. Activation of MPK4 (zeige MAPK4 Antikörper) by flg22 is impaired in the mkk1 (zeige MAP2K1 Antikörper) mkk2 double mutants, suggesting that MKK1 (zeige MAP2K1 Antikörper) and MKK2 function together with MPK4 (zeige MAPK4 Antikörper) and MEKK1 (zeige MAP3K1 Antikörper) in a MAP kinase (zeige MAPK1 Antikörper) cascade to negatively regulate innate immune responses in plants.