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Human Caspase 9 Protein expressed in Escherichia coli (E. coli) - ABIN2487277
Azuma, Koths, Flanagan, Kwiatkowski: Gelsolin in complex with phosphatidylinositol 4,5-bisphosphate inhibits caspase-3 and -9 to retard apoptotic progression. in The Journal of biological chemistry 2000
Show all 8 Pubmed References
Inhibition of caspase-9 aggravates acute liver injury through suppression of cytoprotective autophagy.
inducible caspase-9 (iC9) safety switch can eliminate CD19 (zeige CD19 Proteine).CAR-Ts in a dose-dependent manner, allowing either a selective containment of CD19 (zeige CD19 Proteine).CAR-T expansion in case of CRS (zeige CARS Proteine) or complete deletion on demand granting normal B cell reconstitution.
Cepharanthine treatment reduced mitochondrial membrane potential and upregulated the level of cleaved caspases, including caspase-9 and caspase-3 (zeige CASP3 Proteine)/7, in a dose-dependent fashion.
Bcl-2 (zeige BCL2 Proteine)-caspase-9 apoptosis pathway was clearly activated in the testis of asthmatic mice with the increased expression of apoptosis-related proteins.
Inhibition of Caspase-9 restricted, while Apaf-1 promoted, Chlamydia pneumoniae infection in HEp-2, HeLa, and mouse epithelial fibroblast (MEF) cells.
The study demonstrates sublethal caspase (zeige CASP3 Proteine)-activation has an important role in cardiomyocyte differentiation and may have significant implications for promoting cardiac regeneration after myocardial injury involving exogenous or endogenous cell sources.
Casp6 (zeige CASP6 Proteine) knockout in YAC128 mice does not abolish the presence of the mutant HTT (zeige HTT Proteine) protein-586 fragment but ameliorates depression, body weight gain, IGF-1 (zeige IGF1 Proteine) and BDNF (zeige BDNF Proteine) levels in YAC128 mice.
study demonstrates that MMP-3 (zeige MMP3 Proteine) leads to caspase-9 activation and suggests that this occurs indirectly via a cytosolic protein, possibly involving Apaf-1 (zeige APAF1 Proteine)
caspase-9 mediates Puma (zeige BBC3 Proteine) activation to determine the threshold for overcoming chemoresistance in cancer cells.
Casp9, the initiator caspase (zeige CASP3 Proteine) of the intrinsic apoptotic cascade, has a role in murine fetal and adult hematopoiesis
Low CASP9 expression is associated with Colorectal Cancer.
the results of the present study suggest that miR (zeige MLXIP Proteine)-96-5p, which is frequently upregulated in hepatocellular carcinoma (HCC (zeige FAM126A Proteine)), inhibits apoptosis by targeting CASP9. Therefore, miR (zeige MLXIP Proteine)-96-5p may be a potential therapeutic target for HCC (zeige FAM126A Proteine)
CASP9 germline mutations may have played a role at least in part to the susceptibility of development of gliomas in a Li-Fraumeni-like family lacking a TP53 (zeige TP53 Proteine) germline mutation.
The caspase 9 level was significantly lower and related with oxidant status in patients with polycystic ovary syndrome, while the circulating levels of caspases 3 and 7 were statistically similar in both PCOS and control groups.
Results indicate that the apoptotic protease-activating factor 1 (Apaf-1 (zeige APAF1 Proteine)) apoptosome activates caspase-9 in part through sequestration of the inhibitory caspase (zeige CASP3 Proteine) recruitment domains (CARDs) domain.
1,4-BQ evidently induced mitochondria-mediated apoptosis and increased pro-apoptotic genes (Caspase-9 and Caspase-3 (zeige CASP3 Proteine)) expression in a dose-dependent manner.
DES1 plays a key role in palmitic acid-mediated caspase 9 and caspase 3 (zeige CASP3 Proteine) activation.
CASP9 expression associated with inhibition of miR (zeige MLXIP Proteine)-182.
CASP-9 polymorphism is associated with Primary Brain Tumors.
Fisetin inhibited Triple-Negative Breast Cancer Cells cell division and induced apoptosis, which was associated with mitochondrial membrane permeabilization and the activation of caspase-9 and caspase-8 (zeige CASP8 Proteine), as well as the cleavage of poly(ADP-ribose) polymerase-1 (zeige PARP1 Proteine).
Suppression of caspase-9 resulted in significant upregulation of cell proliferation-, adhesion-, growth-, development- and division-regulating genes, and the downregulation of cell death program- and stress response-regulating genes.
Endothelial cell apoptosis by H. somnus-activated platelets required activation of both caspase-8 (zeige CASP8 Proteine) and caspase-9.
The ATP and cytochrome c (zeige CYCS Proteine) dependent activation of caspase-9 is increased during hypoxia. The ATP and cytochrome c (zeige CYCS Proteine) sites of Apaf-1 (zeige APAF1 Proteine) that mediate caspase-9 activation are modified during hypoxia.
Results suggest that zearalenone induces apoptosis and necrosis of porcine granulosa cells in a dose-dependent manner via a caspase-3 (zeige CASP3 Proteine)- and caspase-9-dependent mitochondrial pathway.
We conclude that the hypoxia-induced activation of caspase-9 is mediated by Src kinase (zeige CSK Proteine).
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1\; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two transcript variants which encode different isoforms.
, ICE-like apoptotic protease 6
, apoptotic protease Mch-6
, apoptotic protease-activating factor 3
, 25 kDa caspase-9 dominant negative protein
, Ice-like apoptotic protease 6
, apoptotic protease activating factor 3
, caspase-9 dominant negative form
, caspase-9-carboxyl-terminal divergent
, apoptotic protease MCH-6
, protein phosphatase 1, regulatory subunit 56
, caspase 9, apoptosis-related cysteine protease