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Results suggest that calnexin is essential for neuromast formation during lateral line development.
Increased tumour protein levels of calnexin may be of prognostic significance in colorectal cancer, and calnexin may represent a potential target for future therapies.
FUNDC1 (zeige FUNDC1 ELISA Kits) integrates mitochondrial fission and mitophagy at the interface of the endoplasmic reticulum-mitochondrial contact site by working in concert with DRP1 (zeige CRMP1 ELISA Kits) and calnexin under hypoxic conditions in mammalian cells.
Results of further analyses by using a CNX mutant imply that ERp29 (zeige ERP29 ELISA Kits) and ERp57 (zeige PDIA3 ELISA Kits) recognize the same domain of CNX, whereas the mode of interaction with CNX might be somewhat different between them.
Inhibit interaction between HIV-1 Nef and Calnexin to reverse HIV-induced lipid accumulation and prevent atherosclerosis.
Endogenous NOX4 (zeige NOX4 ELISA Kits) forms macromolecular complexes with calnexin, which are needed for the proper maturation, processing, and function of NOX4 (zeige NOX4 ELISA Kits) in the endoplasmic reticulum.
To study principles underlying dynamics and regulation of palmitoylation, the ER chaperone calnexin, which requires dual palmitoylation for function, was investigated.
These observations point at a previously unrecognized contribution of calnexin to the retention of NMT1 (zeige NMT1 ELISA Kits) at the ER membrane.
Charcot-Marie-Tooth disease-related PMP22 (zeige PMP22 ELISA Kits) is trapped in the endoplasmic reticulum by calnexin-dependent retention and Rer1 (zeige RER1 ELISA Kits)-mediated early Golgi retrieval systems and partly degraded by the Hrd1 (zeige SYVN1 ELISA Kits)-mediated endoplasmic reticulum-associated degradation system.
Data indicate that protein tyrosine phosphatase 1B (PTP1B (zeige PTPN1 ELISA Kits)) association with calnexin is ubiquitin conjugating enzyme 9 (UBC9 (zeige UBE2I ELISA Kits))-dependent.
H-ERG (zeige KCNH2 ELISA Kits) trafficking was impaired by H2O2 after 48 h treatment, accompanied by reciprocal changes of expression between miR-17-5p seed miRNAs and several chaperones (Hsp70 (zeige HSP70 ELISA Kits), Hsc70 (zeige HSPA8 ELISA Kits), CANX, and Golga20)
CNX has a specific role in cardiomyocyte viability and Ca(2 (zeige CA2 ELISA Kits)+) cycling through its effects on endoplasmic reticulum stress, apoptosis and Ca(2 (zeige CA2 ELISA Kits)+) channel expression.
Calnexin discriminates between different conformational states of GlyT2 displaying a lectin-independent chaperone activity.
calnexin and ERp57 (zeige PDIA3 ELISA Kits), but not calreticulin (zeige CALR ELISA Kits), play an important role in the biology of peripheral myelin proteins PMP22 (zeige PMP22 ELISA Kits) and P0, and, consequently, these chaperones may contribute to the pathogenesis of peripheral neuropathies
Enhanced clathrin-dependent endocytosis in the absence of calnexin may contribute to the neurological phenotype of calnexin-deficient mice
Data show that the E351 mutation led to slightly enhanced ERp57 (zeige PDIA3 ELISA Kits) binding to calnexin, whereas W428 greatly enhanced binding of ERp57 (zeige PDIA3 ELISA Kits) to calnexin.
Suggest that Adam7 (zeige ADAM7 ELISA Kits) functions in fertilization through the formation of a complex with heat shock protein 5 (zeige HSPA5 ELISA Kits), calnexin and Itm2b (zeige ITM2B ELISA Kits) during capacitation in sperm.
endoplasmic reticulum stress has effects on group VIA phospholipase A2 (zeige YWHAZ ELISA Kits) in beta cells that include tyrosine phosphorylation and increased association with calnexin
Calnexin deficiency leads to dysmyelination
Data give novel evidence that CyCAP (zeige LGALS3BP ELISA Kits) regulates the post-translational modification of tissue transglutaminase (zeige TGM2 ELISA Kits) through its colocalization with calnexin in endoplasmic reticulum.
Association with mutant peripheral myelin protein-22 (zeige PMP22 ELISA Kits) ex vivo: a basis for "gain-of-function" ER diseases.
This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described.
major histocompatibility complex class I antigen-binding protein p88
, calnexin 99A
, hypothetical protein