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Human BCL2 Protein expressed in Wheat germ - ABIN1346542
Su, Guo, Qi: Threonine 56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagy. in Biochimica et biophysica acta 2014
The relative gene expression of BCL2 in iodine-125-triplex-forming oligonucleotides-BCL2 transfected cells showed a significant up-regulation when compared to controls.
results showed that fascaplysin inhibited ovarian cancer cell proliferation, invasion and migration, as well as inducing S arrest and cell apoptosis. Treatment with fascaplysin also suppressed CDK4 (zeige CDK4 Proteine), cyclin D1 (zeige CCND1 Proteine), Bcl-2, and VEGFA (zeige VEGFA Proteine) expression at protein levels
Study demonstrated that MYC (zeige MYC Proteine) and BCL2 overexpression was significantly associated with a high scoring class, and was related to shorter progression-free survival and overall survival in patients with primary diffuse large B-cell lymphoma of the central nervous system.
miR (zeige MLXIP Proteine)-143 acts as a suppressor in the growth of HemECs, at least partially, through downregulation of Bcl-2.
Our results suggest that miRNA-143 promotes the progression of nucleus pulposus apoptosis by directly targeting BCL2, providing a potential therapeutic target for the treatment of intervertebral disc degeneration disease.
Anti-CD30 (zeige TNFRSF8 Proteine) mAb-induced human eosinophil apoptosis is likely to be mediated through Bcl-2 and caspase-9 (zeige CASP9 Proteine) and -3.
BCL2 expression in mesennchymal lung cancer cells was induced by ERK1 (zeige MAPK3 Proteine) activity through the upregulation of the MEK1 (zeige MAP2K1 Proteine)/ERK1 (zeige MAPK3 Proteine) scaffold protein (zeige HOMER1 Proteine) MEK partner-1 (zeige MAPKSP1 Proteine). Interfering with the MEK1 (zeige MAP2K1 Proteine)/MP1 (zeige PITRM1 Proteine)/ERK1 (zeige MAPK3 Proteine) axis using a MEK1 (zeige MAP2K1 Proteine) inhibitor or MP1 (zeige PITRM1 Proteine) depletion repressed BCL2 expression and sensitized MLCCs to chemoradiotherapy.
MYC (zeige MYC Proteine) and BCL2 genetic alterations were profiled using next-generation sequencing and high-resolution single nucleotide polymorphism array in 347 de novo diffuse large B-cell lymphoma cases.
findings suggest that expression of cFLIPL regulates the basal interaction of Bcl-2 with Beclin-1 (zeige BECN1 Proteine) and substantiates p53 (zeige TP53 Proteine) dependent ubiquitination of Beclin-1 (zeige BECN1 Proteine) during autophagic stress to determine the fate of cell death or survival.
Our findings suggest that RACK1 (zeige GNB2L1 Proteine) promotes proliferation and radioresistance in ESCC cells by activating the AKT (zeige AKT1 Proteine) pathway, upregulating Bcl-2 expression and downregulating protein levels of Bim (zeige BCL2L11 Proteine). Our study fills in gaps in the field of RACK1 (zeige GNB2L1 Proteine) and radiation resistance and may provide new possibilities for improving strategies of radiotherapy in esophageal cancer.
Bcl-2 expression has a significant impact on the mineralogical content of enamel crystals of tooth structure
The results suggest that CARP (zeige ANKRD1 Proteine) can protect against hypoxia-reperfusion induced cardiomyocyte apoptosis, possibly through increasing anti-apoptosis Bcl2 gene expression.
This study provides evidence from transgenic mouse models that Crebbp (zeige CREBBP Proteine) deletion results in deficits in B-cell development and can cooperate with Bcl2 overexpression to promote B-cell lymphoma.
an essential role for the binding of BCL2 to BIM (zeige BCL2L11 Proteine) in the survival of noncycling NK cells.
LIGHT signalling pathway combined with IFN-gamma (zeige IFNG Proteine) induces beta cells apoptosis via an NF-kappaB (zeige NFKB1 Proteine)/Bcl2-dependent mitochondrial pathway.
Bcl-2 was highly expressed in tubulointerstitial infiltrates in (NZB x NZW)F1 (NZB/NZW) lupus-prone mice.
The abnormal expression of epidermal cytokeratins suggests that Ha-Ras and Bcl-2 suppress the terminal differentiation and sustain the stem cell-like features in epidermal keratinocytes
the augmentation of endogenous MTA1 (zeige MTA1 Proteine) expression during neuronal ischemic injury acts additionally to an endocrinous cascade orchestrating intimate interactions between ERalpha (zeige ESR1 Proteine) and BCL2 pathways.
Interestingly, SKPs showed higher protein levels of Bcl-2, Nrf2 (zeige NFE2L2 Proteine), and HO-1 (zeige HMOX1 Proteine) than FBs (zeige FBS Proteine). SKPs exert a beneficial effect on resisting UVB-induced apoptosis, which may be associated with Bcl-2 and Nrf2 (zeige NFE2L2 Proteine) upregulation.
Bcl-2 is an essential regulator in the survival of doublecortin (zeige DCX Proteine)-expressing immature neurons.
These results suggest a role for mitochondrial p53 (zeige TP53 Proteine) activity in promoting hair cell death due to aminoglycosides, likely upstream of Bax (zeige BAX Proteine) and Bcl2.
Zebrafish gene expressions of P53 (zeige TP53 Proteine), Bcl-2, Bax (zeige BAX Proteine) and caspase-3 (zeige CASP3 Proteine) were elevated after exposure with microcystin-LR under different ambient temperatures.
Analysis using clinical biopsy specimens revealed autophagy and increased levels of BCL2, S1P1 (zeige S1PR1 Proteine), and ICAM1 (zeige ICAM1 Proteine) in human T-lymphoblastic lymphoma compared with T-lymphoblastic leukemia.
Real-time RT-PCR revealed acetaminophen treatment of zebrafish embryos decreased the expression of cox2 and bcl2, but increased p53 (zeige TP53 Proteine) expression.
Leukemia onset was dramatically accelerated in transgenic fish overexpressing human Notch1 (zeige NOTCH1 Proteine) and fish bcl-2, indicating synergy between the Notch (zeige NOTCH1 Proteine) pathway and the bcl2-mediated antiapoptotic pathway.
Over-expression of STC-1 (zeige STC1 Proteine) up-regulated Bcl-2 protein expression and slightly down-regulated caspase-3 (zeige CASP3 Proteine) production in the damaged cells. Findings from this study suggest that STC-1 (zeige STC1 Proteine) plays a protective role in intestinal cells through an antioxidant mechanism.
BoHV-5 replication apparently modulates BCL-2 expression and gene transcription, enhancing production of virus progeny, but does not increase Bax (zeige BAX Proteine) expression.
G3139, a BCL-2 antisesnse oligonucleotide is a promising candidate for treatment of patients with imatinib-resistant Ph-positive leukemia.
role of vascular endothelial growth factor receptor-1 (zeige FLT1 Proteine) in Bcl-2 expression
apoptosis-inducing factor (zeige AIFM1 Proteine) was expressed in luminal alveolar cells and, in concert with a change in bax (zeige BAX Proteine) protein to bcl-2 protein ratio, might contribute to signalling of a change in the dynamic balance of the cell population as lactation progresses
mRNA expression of Bax (zeige BAX Proteine), Bcl-2, caspase-3 (zeige CASP3 Proteine) and-7 cannot be used as a reliable apoptosis detection method.
These results propose an additional mechanism whereby resveratrol may exert its cardioprotective effects and suggest a key role for Bcl-2 in the resveratrol anti-apoptotic action, especially in disrupting peroxynitrite-triggered mitochondrial pathway.
bcl-2 and bax (zeige BAX Proteine) were expressed strongly in denervated guinea-pig facial muscle. [bcl-2; bax (zeige BAX Proteine)]
excessive apoptosis does occur in acetabular cartilage with developmental dislocations of the hip, and is positively correlated with high caspase-3 (zeige CASP3 Proteine) expression as well as low Bcl-2 expression.
These results indicate that RI-PostC can ameliorate myocardial ischemia-reperfusion injury and increase the Bcl-2/Bax ratio through a mechanism involving protein kinase C.
Cinobufagin can remarkably inhibit the proliferation and induce the apoptosis of lens epithelial cells by increasing expression of bax (zeige BAX Proteine) and decreasing expression of bcl2.
Elevated local temperature of the testis buried in the inguinal pocket increases the apoptosis of spermatogenic cells, and the spermatogenic cell apoptosis is highly correlated with the decreased expression of Bcl-2 and increased expression of Bax (zeige BAX Proteine).
Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 (zeige TP53 Proteine) and decrease in the antiapoptotic BCl2 proteins.
Isoflurane delayed preconditioning can inhibit the apoptosis of myocardium by up-regulating the expression of Bcl-2 and down-regulating the activation of caspase-3 (zeige CASP3 Proteine).
Data show that the damaged electron transport chain leads to bcl-2 depletion and MPT opening.
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.
apoptosis regulator Bcl-2
, protein phosphatase 1, regulatory subunit 50
, B cell lymphoma 2 associated oncogene
, B-cell leukemia/lymphoma 2
, Bcl2-like protein
, BCL2B-cell CLL/lymphoma 2
, B-cell lymphoma protein 2
, B-cell CLL/lymphoma 2