BCL2 Proteine (BCL2)

Bezeichnung:
B-Cell CLL/lymphoma 2 Proteine (BCL2)
Auf www.antikoerper-online.de finden Sie aktuell 18 B-Cell CLL/lymphoma 2 (BCL2) Proteine von 8 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen BCL2 Antikörper (1090) und BCL2 Kits (50) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 1191 BCL2 Produkte verfügbar.
Synonyme:
AW986256, bcl-2, Bcl2, C430015F12Rik, D630044D05Rik, D830018M01Rik, PPP1R50
alle Proteine anzeigen Gen GeneID UniProt
BCL2 12043 P10417
BCL2 596 P10415
Ratte BCL2 BCL2 24224 P49950

Weitere Synonyme anzeigen

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Am meisten referenzierte BCL2 Proteine

  1. Human BCL2 Protein expressed in Escherichia coli (E. coli) - ABIN667734 : Fernandez-Sarabia, Bischoff: Bcl-2 associates with the ras-related protein R-ras p23. in Nature 1993 (PubMed)
    Zeige alle 2 Referenzen für 667734

  2. Human BCL2 Protein expressed in Wheat germ - ABIN1346542 : Su, Guo, Qi: Threonine 56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagy. in Biochimica et biophysica acta 2014 (PubMed)

Weitere Proteine zu BCL2 Interaktionspartnern

Mouse (Murine) B-Cell CLL/lymphoma 2 (BCL2) Interaktionspartner

  1. an essential role for the binding of BCL2 to BIM (zeige BCL2L11 Proteine) in the survival of noncycling NK cells.

  2. LIGHT signalling pathway combined with IFN-gamma (zeige IFNG Proteine) induces beta cells apoptosis via an NF-kappaB (zeige NFKB1 Proteine)/Bcl2-dependent mitochondrial pathway.

  3. Bcl-2 was highly expressed in tubulointerstitial infiltrates in (NZB x NZW)F1 (NZB/NZW) lupus-prone mice.

  4. The abnormal expression of epidermal cytokeratins suggests that Ha-Ras and Bcl-2 suppress the terminal differentiation and sustain the stem cell-like features in epidermal keratinocytes

  5. the augmentation of endogenous MTA1 (zeige MTA1 Proteine) expression during neuronal ischemic injury acts additionally to an endocrinous cascade orchestrating intimate interactions between ERalpha (zeige ESR1 Proteine) and BCL2 pathways.

  6. Interestingly, SKPs showed higher protein levels of Bcl-2, Nrf2 (zeige NFE2L2 Proteine), and HO-1 (zeige HMOX1 Proteine) than FBs (zeige FBS Proteine). SKPs exert a beneficial effect on resisting UVB-induced apoptosis, which may be associated with Bcl-2 and Nrf2 (zeige NFE2L2 Proteine) upregulation.

  7. Bcl-2 is an essential regulator in the survival of doublecortin (zeige DCX Proteine)-expressing immature neurons.

  8. Results show that the deletion of BCL-2, on its own or in concert with MCL-1 (zeige MCL1 Proteine), does not affect platelet production or platelet lifespan.

  9. the expression changes observed within the BCL2 family did not depend on STAT3 (zeige STAT3 Proteine) signalling, in line with its initiating role early in the process, but rather appear to result from relief of repression by STAT5 (zeige STAT5A Proteine).

  10. Bcl-2-caspase-9 (zeige CASP9 Proteine) apoptosis pathway was clearly activated in the testis of asthmatic mice with the increased expression of apoptosis-related proteins.

Guinea Pig B-Cell CLL/lymphoma 2 (BCL2) Interaktionspartner

  1. bcl-2 and bax (zeige BAX Proteine) were expressed strongly in denervated guinea-pig facial muscle. [bcl-2; bax (zeige BAX Proteine)]

Human B-Cell CLL/lymphoma 2 (BCL2) Interaktionspartner

  1. Overview of the pleiotropic functions of BCL2 mediated by its physical binding interaction with other proteins and the various ways BCL2 mutations would affect the normal function of the cell leading to the development of diffuse large B-cell lymphomas (review).

  2. Diffuse large B-cell lymphoma with concurrent high MYC (zeige MYC Proteine) and BCL2 expression shows evidence of active B-cell receptor signaling

  3. Case Reports: BCL2 gene translocations are a recurrent feature of a distinct subset of histiocytic sarcomas that are associated with follicular lymphoma.

  4. This study provides evidence that the homozygous BCL2-938 CC genotype is associated with OS and C in prostate cancer patients.

  5. In Diffuse large B-cell lymphoma (DLBCL) evaluation from Taiwan, the relative frequency of germinal center B-cell tumors among DLBCL was low in most East Asian countries. There is a wide range of BCL2 rearrangement rates, higher in the West and lower in East Asia.

  6. Two Distinct BCL2 Rearrangements, Each Observed in 2 Independent Subclones, Evolving from a Founder Clone with Trisomy 12 in a Unique Case of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

  7. BCL2 scoring system could readily be used by pathologists to evaluate patients with diffuse large B-cell lymphoma who might benefit from BCL2-targeted therapies.

  8. Recent studies that combine experiments in yeast and in mammalian cells have shown the unexpected effect of the anti-apoptotic protein Bcl-xL (zeige BCL2L1 Proteine) on the priming of Bax (zeige BAX Proteine). As demonstrated with the BH3-mimetic molecule ABT-737, this property of Bcl-xL (zeige BCL2L1 Proteine), and of Bcl-2, is crucial to elaborate about how apoptosis could be reactivated in tumoral cells.

  9. In the current report, we extend the understanding of the role of BCL2 in HIV infection by demonstrating that BCL2 is necessary for maintaining HIV in the settings of homeostatic proliferation of infected cell lines and acute spreading infection of primary CD4 (zeige CD4 Proteine) T cells.

  10. we indicated that miR (zeige MLXIP Proteine)-34a can inhibit tumor invasion and metastasis in osteosarcoma, and its mechanism may be partly related to downregulating the expression of C-IAP2 (zeige BIRC3 Proteine) and Bcl-2 protein directly or indirectly.

Cow (Bovine) B-Cell CLL/lymphoma 2 (BCL2) Interaktionspartner

  1. Over-expression of STC-1 (zeige STC1 Proteine) up-regulated Bcl-2 protein expression and slightly down-regulated caspase-3 (zeige CASP3 Proteine) production in the damaged cells. Findings from this study suggest that STC-1 (zeige STC1 Proteine) plays a protective role in intestinal cells through an antioxidant mechanism.

  2. BoHV-5 replication apparently modulates BCL-2 expression and gene transcription, enhancing production of virus progeny, but does not increase Bax (zeige BAX Proteine) expression.

  3. G3139, a BCL-2 antisesnse oligonucleotide is a promising candidate for treatment of patients with imatinib-resistant Ph-positive leukemia.

  4. role of vascular endothelial growth factor receptor-1 (zeige FLT1 Proteine) in Bcl-2 expression

  5. apoptosis-inducing factor (zeige AIFM1 Proteine) was expressed in luminal alveolar cells and, in concert with a change in bax (zeige BAX Proteine) protein to bcl-2 protein ratio, might contribute to signalling of a change in the dynamic balance of the cell population as lactation progresses

  6. mRNA expression of Bax (zeige BAX Proteine), Bcl-2, caspase-3 (zeige CASP3 Proteine) and-7 cannot be used as a reliable apoptosis detection method.

  7. These results propose an additional mechanism whereby resveratrol may exert its cardioprotective effects and suggest a key role for Bcl-2 in the resveratrol anti-apoptotic action, especially in disrupting peroxynitrite-triggered mitochondrial pathway.

Rabbit B-Cell CLL/lymphoma 2 (BCL2) Interaktionspartner

  1. excessive apoptosis does occur in acetabular cartilage with developmental dislocations of the hip, and is positively correlated with high caspase-3 (zeige CASP3 Proteine) expression as well as low Bcl-2 expression.

  2. These results indicate that RI-PostC can ameliorate myocardial ischemia-reperfusion injury and increase the Bcl-2/Bax ratio through a mechanism involving protein kinase C.

  3. Cinobufagin can remarkably inhibit the proliferation and induce the apoptosis of lens epithelial cells by increasing expression of bax (zeige BAX Proteine) and decreasing expression of bcl2.

  4. Elevated local temperature of the testis buried in the inguinal pocket increases the apoptosis of spermatogenic cells, and the spermatogenic cell apoptosis is highly correlated with the decreased expression of Bcl-2 and increased expression of Bax (zeige BAX Proteine).

  5. Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 (zeige TP53 Proteine) and decrease in the antiapoptotic BCl2 proteins.

  6. Isoflurane delayed preconditioning can inhibit the apoptosis of myocardium by up-regulating the expression of Bcl-2 and down-regulating the activation of caspase-3 (zeige CASP3 Proteine).

  7. Data show that the damaged electron transport chain leads to bcl-2 depletion and MPT opening.

Zebrafish B-Cell CLL/lymphoma 2 (BCL2) Interaktionspartner

  1. These results suggest a role for mitochondrial p53 (zeige TP53 Proteine) activity in promoting hair cell death due to aminoglycosides, likely upstream of Bax (zeige BAX Proteine) and Bcl2.

  2. Zebrafish gene expressions of P53 (zeige TP53 Proteine), Bcl-2, Bax (zeige BAX Proteine) and caspase-3 (zeige CASP3 Proteine) were elevated after exposure with microcystin-LR under different ambient temperatures.

  3. Analysis using clinical biopsy specimens revealed autophagy and increased levels of BCL2, S1P1 (zeige S1PR1 Proteine), and ICAM1 (zeige ICAM1 Proteine) in human T-lymphoblastic lymphoma compared with T-lymphoblastic leukemia.

  4. Real-time RT-PCR revealed acetaminophen treatment of zebrafish embryos decreased the expression of cox2 and bcl2, but increased p53 (zeige TP53 Proteine) expression.

  5. Leukemia onset was dramatically accelerated in transgenic fish overexpressing human Notch1 (zeige NOTCH1 Proteine) and fish bcl-2, indicating synergy between the Notch (zeige NOTCH1 Proteine) pathway and the bcl2-mediated antiapoptotic pathway.

BCL2 Protein Überblick

Protein Überblick

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.

Alternative names and synonyms associated with BCL2

  • B-cell CLL/lymphoma 2 (BCL2)
  • B-cell CLL/lymphoma 2 (LOC100224888)
  • B cell leukemia/lymphoma 2 (Bcl2)
  • B-cell CLL/lymphoma 2 (Bcl2)
  • B-cell CLL/lymphoma 2 protein (BCL-2)
  • B-cell leukemia/lymphoma 2 (bcl2)
  • AW986256 Protein
  • bcl-2 Protein
  • Bcl2 Protein
  • C430015F12Rik Protein
  • D630044D05Rik Protein
  • D830018M01Rik Protein
  • PPP1R50 Protein

Bezeichner auf Proteinebene für B-Cell CLL/lymphoma 2 Proteine (BCL2)

B-cell lymphoma protein 2 , B-cell leukemia/lymphoma 2 , apoptosis regulator Bcl-2 , B-cell CLL/lymphoma 2 , protein phosphatase 1, regulatory subunit 50 , B cell lymphoma 2 associated oncogene , Bcl2-like protein , BCL2B-cell CLL/lymphoma 2 , PCKBCL2 , Bcl2 , zBlp2

GENE ID SPEZIES
738409 Pan troglodytes
100224888 Taeniopygia guttata
12043 Mus musculus
100733337 Cavia porcellus
596 Homo sapiens
24224 Rattus norvegicus
403416 Canis lupus familiaris
493934 Felis catus
100049703 Sus scrofa
281020 Bos taurus
396282 Gallus gallus
100009447 Oryctolagus cuniculus
570772 Danio rerio
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