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Human BCL2 Protein expressed in Wheat germ - ABIN1346542
Su, Guo, Qi: Threonine 56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagy. in Biochimica et biophysica acta 2014
Polo-like kinase inhibition can sensitize cholangiocarcinoma cells to cisplatin-induced apoptosis with proteasomal Bcl-2 degradation as an additional pro-apoptotic effect.
Lipid oxidation product 4-hydroxy-2-nonenal is at the crossroads of NF-kappaB (zeige NFKB1 Proteine) pathway and anti-apoptotic Bcl2 expression. (Review)
Ibrutinib-resistant TMD8 cells had higher BCL2 gene expression and increased sensitivity to ABT-199, a BCL-2 inhibitor. Consistently, clinical samples from ABC (zeige ABCB6 Proteine)-DLBCL patients who experienced poorer response to ibrutinib had higher BCL2 gene expression. We further demonstrated synergistic growth suppression by ibrutinib and ABT-199 in multiple ABC (zeige ABCB6 Proteine)-DLBCL, GCB (zeige GBA Proteine)-DLBCL, and follicular lymphoma cell lines.
MUC1 (zeige MUC1 Proteine)-C Stabilizes MCL-1 (zeige MCL1 Proteine) in the Oxidative Stress Response of Triple-Negative Breast Cancer Cells to BCL-2 Inhibitors
The BCL2 c.-938C>A and c.21G>A single-nucleotide polymorphisms showed a significant impact on outcome with transitional cell carcinoma of the bladder
High expression of prosurvival BCL2 proteins and inhibition of apoptosis and autophagy prolongs Sertoli survival upon exposure to stress stimuli.
on the basis of data obtained during the study, it can be concluded that these polyphenols have the potential to be used as lead molecules for BCL-2 inhibition.
Tumor cell hypoxia induced Bcl-2/Twist1 (zeige TWIST1 Proteine) complex formation, promoting tumor cell invasion in oral squamous cell carcinoma.
Bcl-2 rs1800477A/G polymorphism may be related to the occurrence of colorectal cancer(CRC (zeige CALR Proteine)), and GG genotype could be a risk factor of poor prognosis in CRC (zeige CALR Proteine).
BTK (zeige BTK Proteine)-mediated signaling was found to be highly attenuated accompanied by a shift in PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) and apoptosis regulation-associated genes/proteins. Cytotoxicity studies using the AKT (zeige AKT1 Proteine) inhibitor, MK2206+/-ibrutinib, and the Bcl-2-specific inhibitor, venetoclax+/-ibrutinib, demonstrated synergistic loss of cell viability
The results suggest that SPK2 (zeige SPHK2 Proteine) interacts with Bcl2 via its BH3 domain, thereby dissociating it from Beclin-1 (zeige BECN1 Proteine) and activating autophagy while protecting neurons against ischemic injury.
The findings support a model in which survival is determined by quantitative participation of multiple anti-apoptotic proteins, BCL2, Mcl1 (zeige MCL1 Proteine), and BCL2A1 (zeige BCL2A1 Proteine), rather than by a single anti-apoptotic protein.
Bcl-2 is strongly expressed in the inner hair cells and spiral ganglion neurons of young mice. In addition, moderate Bcl-2 expression is also detected in the outer hair cells and in the neurons of the auditory cortex. A significant reduction of Bcl-2 expression in the cochlea or auditory cortex is also associated with elevated hearing thresholds and hair cell loss during aging.
Bcl2 is the autophagy-related target of miR (zeige MLXIP Proteine)-449a.
anti-apoptotic molecules BclxL (zeige BCL2L1 Proteine) and Bcl-2 and the pro-apoptotic factors BAD and BID (zeige BID Proteine) cooperate to promote migration of triple-negative breast cancer cells stimulated with cl-CD95L (zeige FASL Proteine).
Acute ethanol exposure induced autophagy-mediated heart toxicity and injury mainly through the ROS (zeige ROS1 Proteine)-JNK (zeige MAPK8 Proteine)-Bcl-2 signaling pathway.
Th17 cells are resistant to glucocorticoid-induced apoptosis and cytokine suppression, at least in part due to high levels of BCL-2. These findings support a role of Th17 cells in glucocorticoid-resistant inflammatory conditions such as certain endotypes of asthma.
E2 protects skeletal myoblasts against apoptosis induced by H2 O2 modulating p53 (zeige TP53 Proteine) and FoxO (zeige FOXO3 Proteine) transcription factors and then their target genes Bcl-2, Bim (zeige BCL2L11 Proteine), Puma (zeige BBC3 Proteine), PERP (zeige PERP Proteine), and MDM2 (zeige MDM2 Proteine), without affecting Noxa (zeige PMAIP1 Proteine) gene.
Bcl-2 expression has a significant impact on the mineralogical content of enamel crystals of tooth structure
The results suggest that CARP (zeige ANKRD1 Proteine) can protect against hypoxia-reperfusion induced cardiomyocyte apoptosis, possibly through increasing anti-apoptosis Bcl2 gene expression.
These results suggest a role for mitochondrial p53 (zeige TP53 Proteine) activity in promoting hair cell death due to aminoglycosides, likely upstream of Bax (zeige BAX Proteine) and Bcl2.
Zebrafish gene expressions of P53 (zeige TP53 Proteine), Bcl-2, Bax (zeige BAX Proteine) and caspase-3 (zeige CASP3 Proteine) were elevated after exposure with microcystin-LR under different ambient temperatures.
Analysis using clinical biopsy specimens revealed autophagy and increased levels of BCL2, S1P1 (zeige S1PR1 Proteine), and ICAM1 (zeige ICAM1 Proteine) in human T-lymphoblastic lymphoma compared with T-lymphoblastic leukemia.
Real-time RT-PCR revealed acetaminophen treatment of zebrafish embryos decreased the expression of cox2 and bcl2, but increased p53 (zeige TP53 Proteine) expression.
Leukemia onset was dramatically accelerated in transgenic fish overexpressing human Notch1 (zeige NOTCH1 Proteine) and fish bcl-2, indicating synergy between the Notch (zeige NOTCH1 Proteine) pathway and the bcl2-mediated antiapoptotic pathway.
Over-expression of STC-1 (zeige STC1 Proteine) up-regulated Bcl-2 protein expression and slightly down-regulated caspase-3 (zeige CASP3 Proteine) production in the damaged cells. Findings from this study suggest that STC-1 (zeige STC1 Proteine) plays a protective role in intestinal cells through an antioxidant mechanism.
BoHV-5 replication apparently modulates BCL-2 expression and gene transcription, enhancing production of virus progeny, but does not increase Bax (zeige BAX Proteine) expression.
G3139, a BCL-2 antisesnse oligonucleotide is a promising candidate for treatment of patients with imatinib-resistant Ph-positive leukemia.
role of vascular endothelial growth factor receptor-1 (zeige FLT1 Proteine) in Bcl-2 expression
apoptosis-inducing factor (zeige AIFM1 Proteine) was expressed in luminal alveolar cells and, in concert with a change in bax (zeige BAX Proteine) protein to bcl-2 protein ratio, might contribute to signalling of a change in the dynamic balance of the cell population as lactation progresses
mRNA expression of Bax (zeige BAX Proteine), Bcl-2, caspase-3 (zeige CASP3 Proteine) and-7 cannot be used as a reliable apoptosis detection method.
These results propose an additional mechanism whereby resveratrol may exert its cardioprotective effects and suggest a key role for Bcl-2 in the resveratrol anti-apoptotic action, especially in disrupting peroxynitrite-triggered mitochondrial pathway.
bcl-2 and bax (zeige BAX Proteine) were expressed strongly in denervated guinea-pig facial muscle. [bcl-2; bax (zeige BAX Proteine)]
excessive apoptosis does occur in acetabular cartilage with developmental dislocations of the hip, and is positively correlated with high caspase-3 (zeige CASP3 Proteine) expression as well as low Bcl-2 expression.
These results indicate that RI-PostC can ameliorate myocardial ischemia-reperfusion injury and increase the Bcl-2/Bax ratio through a mechanism involving protein kinase C.
Cinobufagin can remarkably inhibit the proliferation and induce the apoptosis of lens epithelial cells by increasing expression of bax (zeige BAX Proteine) and decreasing expression of bcl2.
Elevated local temperature of the testis buried in the inguinal pocket increases the apoptosis of spermatogenic cells, and the spermatogenic cell apoptosis is highly correlated with the decreased expression of Bcl-2 and increased expression of Bax (zeige BAX Proteine).
Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 (zeige TP53 Proteine) and decrease in the antiapoptotic BCl2 proteins.
Isoflurane delayed preconditioning can inhibit the apoptosis of myocardium by up-regulating the expression of Bcl-2 and down-regulating the activation of caspase-3 (zeige CASP3 Proteine).
Data show that the damaged electron transport chain leads to bcl-2 depletion and MPT opening.
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.
apoptosis regulator Bcl-2
, protein phosphatase 1, regulatory subunit 50
, B cell lymphoma 2 associated oncogene
, B-cell leukemia/lymphoma 2
, Bcl2-like protein
, BCL2B-cell CLL/lymphoma 2
, B-cell lymphoma protein 2
, B-cell CLL/lymphoma 2
, LOW QUALITY PROTEIN: apoptosis regulator Bcl-2
, Apoptosis regulator Bcl-2