Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
Bad functions as an essential sensitizer and Puma (zeige BBC3 Proteine) as an essential activator of IR-induced mitochondrial apoptosis specifically in embryonic neural tissue.
Stage-specific expression of TNFalpha (zeige TNF Proteine) regulates bad/bid (zeige BID Proteine)-mediated apoptosis and RIP1 (zeige RALBP1 Proteine)/ROS (zeige ROS1 Proteine)-mediated secondary necrosis in Birnavirus-infected fish cells.
Results indicate that zebrafish BH3-only (zeige BBC3 Proteine) proapoptotic protein (BAD) could induce apoptosis in vitro and in vivo and may have biological implications in apoptosis during zebrafish development.
The findings suggest that experimental hyperthermia (EH) exposure leads to simultaneous activation of molecular switches of apoptosis (BCL2 (zeige BCL2 Proteine) and BAD) in cells of the follicular epithelium of the ovaries on days 3 and 4 after EH.
Data suggest that ECAD (zeige CDH1 Proteine), STAT3 (zeige STAT3 Proteine), Bak (zeige BAK1 Proteine), and Bcl-xL (zeige BCL2L1 Proteine) are expressed in affected endometrial tissues of women with endometrioid adenocarcinoma depending on neoplasm staging and cell differentiation. This study was conducted using immunohistochemistry of surgically resected tissues. (ECAD (zeige CDH1 Proteine) = E-cadherin (zeige CDH1 Proteine); STAT3 (zeige STAT3 Proteine) = signal transducer and activator of transcription 3 (zeige STAT3 Proteine) protein; Bak (zeige BAK1 Proteine) = pro-apoptotic protein BAK (zeige BAK1 Proteine))
cyclin D1 was downregulated, whereas Bcell lymphoma 2associated agonist of cell death (BAD) was upregulated following RAC1 knockdown in colon cancer cells.
we have found that a subgroup of colorectal cancers, defined by having either KRAS or BRAF (zeige BRAF Proteine) (KRAS/BRAF (zeige BRAF Proteine)) mutations and BCL2L1 (zeige BCL2L1 Proteine) (encoding BCL-XL (zeige BCL2L1 Proteine)) amplification, can be effectively targeted by simultaneous inhibition of BCL-XL (zeige BCL2L1 Proteine) (with ABT-263) and MCL1 (zeige MCL1 Proteine) (with YM-155).
BAD phosphorylation is essential in the cytoprotective effect of vasoactive intestinal peptide (zeige Vip Proteine) on cancer stem cells.
NDRG2 (zeige NDRG2 Proteine) could inhibit Bad degradation by increasing its protein stability in breast cancer cells.
Taken together, our results provide a structural basis for the binding mechanism between DJ-1 (zeige PARK7 Proteine) and Bcl-XL (zeige BCL2L1 Proteine), which will contribute to molecular understanding of the role of mitochondrial DJ-1 (zeige PARK7 Proteine) in Bcl-XL (zeige BCL2L1 Proteine) regulation in response to oxidative stress.
We will then review how the apoptotic and autophagic functions of Bcl-xL (zeige BCL2L1 Proteine) are modified by this post-translational modifications, and how this impacts on its oncogenic properties.
the membrane localization of BCL-xL (zeige BCL2L1 Proteine) enforces its control over cell survival and, importantly, limits the pro-apoptotic effects of BH3 mimetics by selectively influencing BCL-xL (zeige BCL2L1 Proteine) binding to key pro-apoptotic effectors.
The long unstructured region of Bcl-xl (zeige BCL2L1 Proteine) modulates its structural dynamics.
This study shows for the first time that genetic knockout of Bad provides epileptic seizure protection in Kcna1 (zeige KCNA1 Proteine)-/- mice, a genetic model of epilepsy with sudden unexplained death.
Bad is dispensable for TNF (zeige TNF Proteine)-mediated cell death.
Results indicate the downstream targets of insulin (zeige INS Proteine), cyclin D1 (zeige CCND1 Proteine), BAD, alpha-MHC (zeige MYH6 Proteine), and GATA-4 (zeige GATA4 Proteine), elucidate a molecular mechanism of insulin (zeige INS Proteine) in promoting cell proliferation and differentiation.
our study suggests that Bad and Bmf (zeige BMF Proteine) co-regulate lymphocyte homeostasis and limit spontaneous transformation by mechanisms that may not exclusively be linked to the induction of lymphocyte apoptosis.
Results reveal that IKK (zeige CHUK Proteine) inhibits TNFalpha (zeige TNF Proteine)-induced apoptosis through two distinct but cooperative mechanisms: activation of the survival factor NF-kappaB (zeige NFKB1 Proteine) and inactivation of the proapoptotic BH3-only (zeige BBC3 Proteine) BAD protein.
RNAi-mediated silencing of STAT1 (zeige STAT1 Proteine) in soft tissue sarcoma (STS (zeige STS Proteine)) cells was sufficient to increase expression of the apoptotic mediators Fas (zeige FAS Proteine) and Bad and to elevate the sensitivity of STS (zeige STS Proteine) cells to Fas (zeige FAS Proteine)-mediated apoptosis
Tonicity-induced COX-2 expression and PGE2 synthesis in the renal medulla entails phosphorylation and inactivation of the pro-apoptotic protein Bad, thereby counteracting apoptosis in renal medullary epithelial cells.
Caspase-3 (zeige CASP3 Proteine) is activated by the BAD-BAX (zeige BAX Proteine) cascade resulting in long term depression induction in the hippocampus.
JNK1 (zeige MAPK8 Proteine) is required for erythropoietin (zeige EPO Proteine)-mediated cell survival through phosphorylation and inactivation of the pro-apoptotic, Bcl-2 (zeige BCL2 Proteine) homology domain 3 (BH3)-only (zeige BBC3 Proteine) Bcl-associated death protein (Bad).
Bad protein cooperate with bim (zeige BCL2L11 Proteine) protein in certain apoptotic responses and in the suppression of g-irradiation-induced thymic lymphoma.(Bad protein)
The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.
proapoptotic BH3-only protein
, BCL2-antagonist of cell death
, BCL2-associated agonist of cell death
, BCL-X/BCL-2 binding protein
, BCL2-antagonist of cell death protein
, BCL2-binding component 6
, BCL2-binding protein
, bcl-2-binding component 6
, bcl-2-like protein 8
, bcl-XL/Bcl-2-associated death promoter
, bcl2 antagonist of cell death
, Bcl-associated death promoter
, bcl-xL/Bcl-2-associated death promoter
, Bcl2-antagonist of cell death
, bcl-2 associated death agonist
, bcl2-associated death promoter