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Results show that ATF2 is highly expressed in renal cell carcinoma (RCC (zeige XRCC1 ELISA Kits)) tissues and promotes RCC (zeige XRCC1 ELISA Kits) cell proliferation, migration and invasion. The study suggests that ATF2 exerts an oncogenic role in RCC (zeige XRCC1 ELISA Kits).
These findings point to an oncogenic function for ATF2 in melanoma development that appears to be independent of its transcriptional activity.
this study demonstrates that CPEB2 (zeige CPEB2 ELISA Kits) alternative splicing is a major regulator of key cellular pathways linked to anoikis resistance and metastasis.
Noxin (zeige C11orf82 ELISA Kits) facilitated the expression of Cyclin D1 (zeige CCND1 ELISA Kits) and Cyclin E1 (zeige CCNE1 ELISA Kits) through activating P38 (zeige CRK ELISA Kits)-activating transcription factor 2 signaling pathway, thus enhanced cell growth of breast cancer
these observations suggest that CD99 (zeige CD99 ELISA Kits) is involved in the regulation of CD1a (zeige CD1A ELISA Kits) transcription and expression by increasing ATF-2.
This review provides an overview of the currently known upstream regulators and downstream targets of ATF2. [review]
TNF (zeige TNF ELISA Kits) induces the binding of ATF2 to the TNF (zeige TNF ELISA Kits)-responsive element.
miR (zeige MLXIP ELISA Kits)-204 may act as a tumor suppressor by directly targeting ATF2 in non-small cell lung cancer
the variant alleles of TSG101 (zeige TSG101 ELISA Kits) rs2292179 and ATF2 rs3845744 were associated with a reduced risk of breast cancer, particularly for subjects with BMI <24 (kg/m(2)) and postmenopausal women, respectively
Results reveal that mitochondrial ATF2 is associated with the induction of apoptosis and BRAF (zeige BRAF ELISA Kits) inhibitor resistance through Bim (zeige BCL2L11 ELISA Kits) activation.
This study reveals that Drosophila ATF-2 (dATF-2) is required for heterochromatin assembly, whereas the stress-induced phosphorylation of dATF-2, via Mekk1 (zeige MAP3K1 ELISA Kits)-p38 (zeige MAPK14 ELISA Kits), disrupts heterochromatin.
ATF-2 is critical for regulation of fat metabolism.
dATF-2 is activated by the locomotor while it increases sleep, suggesting a role for dATF-2 as a regulator to connect sleep with locomotion.
The current data shows a timely GFP translation in bovine embryos depending on sequences in the 3'UTR (zeige UTS2R ELISA Kits) of ATF1 (zeige AFT1 ELISA Kits)/2, and indicates a difference between short and long isoforms.
Ang II (zeige AGT ELISA Kits) increases endothelial arginase activity/expression through a p38 MAPK (zeige MAPK14 ELISA Kits)/ATF-2 pathway leading to reduced endothelial NO production
Data indicate that Ser738/742-to-glutamate (zeige GRIN2A ELISA Kits) protein kinase D (zeige PRKD1 ELISA Kits) mutant increased AngII-induced CREB (zeige CREB1 ELISA Kits) protein and activating transcription factor 2 phosphorylation, and phospho-CREB (zeige CREB1 ELISA Kits) binding to the steroidogenic acute regulatory protein (zeige STAR ELISA Kits) promoter.
adiponectin inhibited endoplasmic reticulum stress and apoptosis of adipocyte in vivo and in vitro by activating the AMPK (zeige PRKAA1 ELISA Kits)/PPARalpha (zeige PPARA ELISA Kits)/ATF2 pathway.
Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting were used to detect the mRNA and protein expressions of p-p38MAPK (zeige MAPK14 ELISA Kits), AAT, signal transducer and activator of transcription 1 (STAT1 (zeige STAT1 ELISA Kits)) and activating transcription factor2 (ATF2)
increased expression of the gene encoding PKCepsilon (zeige PRKCE ELISA Kits) and abundance of phosphorylated, transcriptionally active ATF2 were observed in advanced-stage melanomas and correlated with decreased FUK (zeige FUK ELISA Kits) expression
These data identified a role for ATF2 in regulating melanocyte responses.
suppression of tumorigenesis by JNK (zeige MAPK8 ELISA Kits) requires ATF2.
Taken together, our observations indicated that SOCS2 (zeige SOCS2 ELISA Kits) could suppress myotube formation, act as an anti-regulator of mitochondria biogenesis via inhibiting p38 MAPK (zeige MAPK14 ELISA Kits) signal pathway.
ATF2 is an important transcriptional factor relating to inflammation through the suppression of ATF3 (zeige ATF3 ELISA Kits) in M1 macrophages of White adipose tissue.
ATF-2 plays critical roles for proper expression of tyrosine hydroxylase (zeige TH ELISA Kits) gene and for neurite extension of catecholaminergic neurons, possibly through repressor-like action.
these studies show that the IL-1beta (zeige IL1B ELISA Kits)-induced increase in intestinal tight junction permeability was regulated by p38 (zeige CRK ELISA Kits) kinase activation of ATF-2 and by ATF-2 regulation of MLCK (zeige MYLK ELISA Kits) gene activity
ATF2-based luciferase reporter to monitor non-canonical Wnt (zeige WNT2 ELISA Kits) signaling in Xenopus embryos.
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro\; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Several alternatively spliced transcript variants have been found for this gene.
, activating transcription factor 2 splice variant ATF2-var2
, cAMP response element-binding protein CRE-BP1
, cAMP responsive element binding protein 2, formerly
, cAMP-dependent transcription factor ATF-2
, cAMP-responsive element-binding protein 2
, cyclic AMP-dependent transcription factor ATF-2
, cyclic AMP-responsive element-binding protein 2
, activating transcription factor-2, isoform A
, activating transcription factor-2, isoform C
, activating transcription factor-2, isoform B
, cyclic AMP response element binding protein 2
, chimerin (chimaerin) 1