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Human Polyclonal TACC3 Primary Antibody für IHC, IHC (p) - ABIN4357500
Guo, Partch, Key, Card, Pashkov, Patel, Bruick, Wurdak, Gardner: Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules. in ACS chemical biology 2013
Human Monoclonal TACC3 Primary Antibody für WB - ABIN2838594
Lin, Hu, Shih: Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability. in The Journal of cell biology 2010
Show all 6 Pubmed References
Tacc3 is required for the proper mitosis of Apc (zeige APC Antikörper)-deficient ISCs (zeige NFS1 Antikörper), and its disruption significantly attenuated the expansion of the crypt domain. In vivo analysis of corresponding mutant mice demonstrated that Tacc3 disruption led to a significant decrease in tumor number and prolonged survival.
Aurora-A kinase (zeige AURKA Antikörper) does not regulate TACC3-chTOG (zeige CKAP5 Antikörper) complex formation, indicating that Aurora-A (zeige AURKA Antikörper) solely functions as a recruitment factor for the TACC3-chTOG (zeige CKAP5 Antikörper) complex to centrosomes and proximal mitotic spindles.
The TACC3 and clathrin were interdependent for spindle recruitment, having to interact in order for either to be recruited to the spindle.
DOCK7 (zeige DOCK7 Antikörper) interaction with TACC3 controls interkinetic nuclear migration and the genesis of neurons from radial glial progenitor cells during cortical development
results show that Tacc3 is a vulnerable component of the spindle assembly in lymphoma cells and is a promising cancer chemotherapy target
Tacc3 is a negative regulator of the Notch (zeige NOTCH1 Antikörper) signaling pathway.
role in hematopoietic stem cell function and interface with p53 (zeige TP53 Antikörper)-regulated apoptosis
the alpha-helix of FOG (zeige APAF1 Antikörper)-ZF3 recognizes a C-terminal portion of the TACC3 coiled-coil.
in addition to spindle assembly, Tacc3 has critical roles in chromosome separation and cytokinesis, and is essential for the mitosis of sclerotome mesenchymal cells during axial formation in mammals.
Results show that TACC3 region of FGFR3 (zeige FGFR3 Antikörper)-TACC3 gene fusion can bind and recruit endogenous TACC3 from the spindle. This reduction in TACC3 levels on the mitotic spindle is the primary cause of mitotic defects in urinary bladder.
FGFR3 (zeige FGFR3 Antikörper)-TACC3 is a recurrent resistance mechanism, which can bypass EGFR (zeige EGFR Antikörper) blockade by all generations of EGFR (zeige EGFR Antikörper) TKIs in NSCLC.
TACC3 rs798766 is associated with increased risk of bladder cancer, and no ethnic difference was found.
High levels of TACC3 in human mammary epithelial cells can cause genomic instability possibly in part through destabilizing BRCA1.
TACC3 was highly expressed in CCA (zeige FBN2 Antikörper) tissues and predicted a poor prognosis in CCA (zeige FBN2 Antikörper) patients. TACC3 knockdown induced G2/M cycle arrest and suppressed the invasion, metastasis, and proliferation of CCA (zeige FBN2 Antikörper) cells, both in vitro and in vivo.
Data indicate that transforming acidic coiled-coil protein-3 (zeige HSPB3 Antikörper) (TACC3) promotes CRC (zeige CALR Antikörper) progression and could be an independent prognostic factor and a potential therapeutic target for colorectal cancer (CRC (zeige CALR Antikörper)).
results suggest that TACC3 is an independent prognostic factor and may be a novel therapeutic target for the treatment of ST
The combination treatment of SNIPER(TACC3) and bortezomib exhibited a synergistic anticancer activity in several cancer cell lines.
Study provides evidence of the significant oncogenic potential of the FGFR3 (zeige FGFR3 Antikörper)-TACC3 fusion protein. The presence of the TACC coiled-coil domain leads to increased and altered levels of FGFR3 (zeige FGFR3 Antikörper) activation, fusion protein phosphorylation, downstream signaling, cellular transformation, proliferation, and viability.
Taken together, these findings uncover a supportive role for TACC3 in PCa (zeige FLVCR1 Antikörper) metastasis, which is mediated by the activation of the Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling pathway, suggesting that TACC3 may serve as a prognostic marker in patients with metastatic PCa (zeige FLVCR1 Antikörper).
TACC1 (zeige TACC1 Antikörper) and TACC3 are each required for maintaining normal microtubule growth speed in Xenopus
XTACC3 can induce the recruitment of larger amounts of XMAP215 (zeige CKAP5 Antikörper) by increasing its local concentration, thereby promoting efficient microtubule elongation during mitosis
TACC3 promotes axon outgrowth and regulates microtubule dynamics in multiple embryonic cell types.
Results suggest that phosphorylation of maskin by Aurora-A (zeige AURKA Antikörper) prevents meiosis II proteins from being produced during meiosis I.
Maskin functions in mitotic spindle assembly.
Maskin activity and localization is controlled by differential phosphorylation
Maskin phosphorylation-dephosphorylation also oscillates with the cell cycle and is controlled by the kinase CDK1 and the phosphatase calcineurin
Maskin mRNA is translationally regulated by at least two repressor elements and an activation element.
This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells.
, Arnt interacting protein
, transforming acidic coiled-coil-containing protein 3
, transforming acidic coiled coil 3
, CPEB-associated factor Maskin
, cytoplasmic polyadenylation element-binding protein-associated factor Maskin