This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008].
Flach, Leu, Martinisi, Skachokova, Frank, Tolnay, Stahlberg, Winkler: "Trans-seeding of Alzheimer-related tau protein by a yeast prion." in: Alzheimer's & dementia : the journal of the Alzheimer's Association, Vol. 18, Issue 12, pp. 2481-2492, (2023) (PubMed).
Aliase für MAPT Proteine
microtubule associated protein tau (MAPT) Proteine microtubule-associated protein tau (Mapt) Proteine microtubule associated protein tau S homeolog (mapt.S) Proteine microtubule-associated protein tau (LOC5580230) Proteine microtubule-associated protein tau (CpipJ_CPIJ013260) Proteine Microtubule-associated protein tau (tau) Proteine microtubule associated protein tau (Mapt) Proteine solute carrier family 6 (neurotransmitter transporter), member 6b (slc6a6b) Proteine AI413597 Proteine AW045860 Proteine DDPAC Proteine FTDP-17 Proteine MAPT Proteine MAPTL Proteine MSTD Proteine Mtapt Proteine MTBT1 Proteine MTBT2 Proteine PHF-tau Proteine PPND Proteine pTau Proteine RNPTAU Proteine slc6a6 Proteine TAU Proteine Tau Proteine tau Proteine taut Proteine wu:fc26e12 Proteine xtp Proteine