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MAP3K4 Proteine

(Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4))
The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].

3 Treffer :

custom-made MAP3K4 Spezies: Maus Wirt: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Produktnummer ABIN7562185
 
custom-made MAP3K4 Spezies: Human Wirt: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Produktnummer ABIN7554437
 
MAP3K4 Spezies: Human, Maus, Ratte Wirt: Escherichia coli (E. coli) Recombinant PC, WB
Produktnummer ABIN2750508
 
  • Typ Protein
    • Protein
  • Anwendung
    • Positive Control (PC)
    • Western Blotting (WB)
  • Reaktivität
    • Human
    • Mouse
    • Rat
  • Abbildungen verfügbar
  • Wirt
    • HEK-293 Cells
    • Escherichia coli (E. coli)
  • Bindungsspezifität
    • AA 1-1597
    • AA 1-1608
  • Konjugat
    • His tag
    • Unkonjugiert
  • Protein-Typ
    • Recombinant
  • Format
    • Liquid
  • Grade
    • custom-made
  • Hersteller
    • antibodies-online
    • FabGennix

Aliase für MAP3K4 Proteine

mitogen activated protein kinase kinase kinase 4 (Map3k4) Proteine
mitogen-activated protein kinase kinase kinase 4 (MAP3K4) Proteine
mitogen-activated protein kinase kinase kinase 4 (Map3k4) Proteine
D17Rp17 Proteine
D17Rp17e Proteine
MAPKKK4 Proteine
Mek4b Proteine
MEKK4 Proteine
MEKK 4 Proteine
Mekk4 Proteine
mKIAA0213 Proteine
MTK1 Proteine
PRO0412 Proteine
RP17 Proteine
Rp17a Proteine
Tas Proteine
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