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The authors show that the Astrin-SKAP (zeige KNSTRN Proteine) complex binds synergistically to microtubules with the Ndc80 (zeige NDC80 Proteine) complex to form an integrated interface.
Data show that aurora-B (zeige AURKB Proteine) regulates end-on conversion in human cells and indicate a late role for SPAG5 protein (Astrin)-SKAP (zeige KNSTRN Proteine) complex in the end-on conversion process.
Low SPAG5 expression is associated with low chemotherapy sensitivity in breast cancer.
findings reveal a direct physical link between two important regulators of mitotic progression and demonstrate the critical role of the NuMA-Astrin interaction for accurate cell division.
Mechanistically, Plk1 acts as an upstream kinase for Astrin phosphorylation by Cdk1 (zeige CDK1 Proteine) and targeting phospho-Astrin to KTs, leading to the recruitment of outer KT components, such as Cenp-E (zeige CENPE Proteine), and the stable attachment of spindles to KTs.
Results showed a progression-driving role of SPAG5 in prostate cancer which can be regulated by miR (zeige MLXIP Proteine)-539.
Molecular requirements for the inter-subunit interaction and kinetochore recruitment of SKAP (zeige KNSTRN Proteine) and Astrin have been reported.
SPAG5 upregulation relates to poor prognosis in cervical cancer patients, and SPAG5 is a regulator of mTOR (zeige FRAP1 Proteine) activity during taxol treatment in cervical cancer.
Astrin acts as a mitotic phosphoprotein during the regulation of mitosis.
Study identifies astrin as an essential negative mTORC1 regulator in the cellular stress response. Upon stress, astrin inhibits mTORC1 association and recruits the mTORC1 component raptor (zeige RPTOR Proteine) to stress granules, thereby preventing mTORC1-hyperactivation-induced apoptosis.
cloning and genomic structure of mastrin; mastrin protein was demonstrated to localize to mitotic spindles during mitosis[masatrin]
Loss-of-function of Astrin by RNAi and overexpression of the coiled-coil domain results in spindle disorganization, chromosome misalignment and meiosis progression arrest.
This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles.
sperm associated antigen 5
, sperm-associated antigen 5-like
, mitotic spindle associated protein p126
, mitotic spindle coiled-coil related protein
, mitotic spindle-associated protein p126
, sperm-associated antigen 5
, microtubule-associated protein