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Human Apolipoprotein C-II Protein expressed in HEK-293 Cells - ABIN2714825
Pan, Zhou, Mahsut, Rohm, Berejnaia, Price, Chen, Castro-Perez, Lassman, McLaren, Conway, Jensen, Thomas, Reyes-Soffer, Ginsberg, Gutstein, Cleary, Previs, Roddy: Static and turnover kinetic measurement of protein biomarkers involved in triglyceride metabolism including apoB48 and apoA5 by LC/MS/MS. in Journal of lipid research 2016
the apoc2 mutant zebrafish is a robust and versatile animal model to study hypertriglyceridemia.
Triglyceride-raising variant alleles of the APOC2 encoding apo (zeige C9orf3 Proteine) C-II, associated with clinical Cardiovascular endpoints.
The results demonstrate the important role of both intra- and inter-subunit charge interactions in stabilizing apoC-II amyloid fibrils, a process that may be a key factor in determining the general ability of proteins to form amyloid fibrils.
The results highlight the importance of charge-pair interactions within the apoC-II fibril core
Conformational rearrangement of apoC-II at lipoprotein surfaces promotes interaction with LPL (zeige LCP1 Proteine).
Large deletion in APOC2 caused by Alu-Alu homologous recombination is associated with with apolipoprotein C-II deficiency.
No APOC2 mutations were identified in a cohort of patients with diabetic lipemia.
Six apolipoproteins (APOA1 (zeige APOA1 Proteine), APOA2 (zeige APOA2 Proteine), APOB (zeige APOB Proteine), APOC2, APOC3 (zeige APOC3 Proteine), and APOE (zeige APOE Proteine)) were able to differentiate bladder cancer from hernia. SAA4 (zeige SAA4 Proteine) was significantly increased in bladder cancer subgroups, whereas ProEGF was significantly decreased in bladder cancer subgroups.
STAT1 (zeige STAT1 Proteine) bound on multienhancer 2 cooperates with RXRalpha (zeige RXRA Proteine) located on apoCII promoter and upregulates apoCII expression only in macrophages.
Mutations in GPIHBP1 (zeige GPIHBP1 Proteine) are rare but the associated clinical phenotype of hypertriglyceridaemia is severe
These results support a predictive change in the ratio of plasma ApoCIII (zeige APOC3 Proteine) to ApoCII in pregnancies complicated by severe preeclampsia.
A novel mouse model of apoC-II deficiency was created with an apoC-II peptide that reverses the hypertriglyceridemia.
Data show that apoC-II and LPL (zeige LPL Proteine) mRNAs correlate temporally and geographically with surfactant lipid synthesis in preparation for birth and suggest that fatty acid recruitment from the circulation by apoC-II-activated LPL (zeige LPL Proteine) is modulated by apoC-II secretion.
TR4 (zeige NR2C2 Proteine) can also regulate apolipoprotein E (zeige APOE Proteine), C-I, and C-II gene expression via the TR4 (zeige NR2C2 Proteine) response element within the hepatic control region
This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene.
, apolipoprotein C2