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Aortic endothelial cells transcytose high-density lipoproteins by mechanisms that involve either SR-BI (zeige SCARB1 Proteine) or ABCG1 but not ABCA1 (zeige ABCA1 Proteine).
High ABCG1 expression is associated with glioma.
ABCG1 regulates pulmonary surfactant metabolism
Hepatic free cholesterol content was significantly increased in NASH (zeige SAMSN1 Proteine) as compared to non-NASH (zeige SAMSN1 Proteine) subjects, while ABCA1 (zeige ABCA1 Proteine) and ABCG1 protein levels significantly decreased with NASH (zeige SAMSN1 Proteine) and fibrosis progression. The relative expression of miR (zeige MLXIP Proteine)-33a and miR (zeige MLXIP Proteine)-144 correlated inversely with ABCA1 (zeige ABCA1 Proteine) but not with ABCG1 protein levels. miR (zeige MLXIP Proteine)-33a/144 and their target gene ABCA1 (zeige ABCA1 Proteine) may contribute to the pathogenesis of NASH (zeige SAMSN1 Proteine) in morbidly obese subjects.
Understanding the relationship between cholesterol and inflammation in the lung, and the role that ABC (zeige ABCB6 Proteine) transporters play in this may illuminate new pathways to target for the treatment of inflammatory lung diseases
Findings suggest that the ABCG1-mediated efflux of cholesterol, but not of 7-ketocholesterol, shows specificity for structural domains of apoA-I (zeige APOA1 Proteine) bound to reconstituted HDL (zeige HSD11B1 Proteine). Although the mid region alone of apoA-I (zeige APOA1 Proteine) associated to rHDL can promote ABCG1-mediated cholesterol efflux, deletion of carboxyl-terminal region 185-243 from full-length apoA-I (zeige APOA1 Proteine) diminishes ABCG1-mediated cholesterol efflux.
ABCG1 regulates T cell differentiation into Tregs, highlighting a pathway by which cholesterol accumulation can influence T cell homeostasis in atherosclerosis
Data show that ELOVL7, SOCS3 (zeige SOCS3 Proteine), ACSL4 (zeige ACSL4 Proteine) and CLU (zeige CLU Proteine) were upregulated while PRKAR1A (zeige PRKAR1A Proteine) and ABCG1 were downregulated in the phlegm-dampness group.
ABCG1 and ABCG4 (zeige ABCG4 Proteine) alter the distribution of gamma-secretase on the plasma membrane, leading to the decreased gamma-secretase activity and suppressed Abeta (zeige APP Proteine) secretion
Both the full-length and the short isoforms of ABCG1 can dimerize with ABCG4 (zeige ABCG4 Proteine), whereas the ABCG2 multidrug transporter is unable to form a heterodimer with ABCG4 (zeige ABCG4 Proteine).
DNA methylation (zeige HELLS Proteine) at the ABCG1 locus cg06500161 in blood DNA was associated with an increased risk for future type2 diabetes.
TMP upregulated the protein stability of ABCA1 (zeige ABCA1 Proteine) without affecting ABCG1. Accordingly, TMP regulated the expression of SR-A (zeige MSR1 Proteine), CD36 (zeige CD36 Proteine), ABCA1 (zeige ABCA1 Proteine) and ABCG1 in aortas of ApoE (zeige APOE Proteine)-/- mice, which resembled the findings observed in macrophages.
Our data indicate that a combination of vildagliptin and pravastatin significantly induces the expression of LXR (zeige NR1H3 Proteine)-ABCA1 (zeige ABCA1 Proteine)/ABCG1 cascade and improves cholesterol efflux (P > 0.05) in adipocytes. Our data may explain, at least in part, the improvement in HDL (zeige HSD11B1 Proteine)-C levels observed in patients receiving both medications
ABCG1 may play a protective role in early-stage atherosclerosis by reducing endothelial activation induced by oscillatory shear stress via suppressing the inflammatory response.
Endothelial cholesterol efflux pathways mediated by ABCA1 and ABCG1 are nonredundant and atheroprotective, reflecting preservation of endothelial NO synthase activity and suppression of endothelial inflammation, especially in regions of disturbed arterial blood flow.
ABCG1, irrespective of either a leucine or proline at position 550, is an intracellular protein (zeige CKAP2 Proteine) that localizes to vesicles of the endosomal pathway where it functions to mobilize sterols away from the endoplasmic reticulum and out of the cell.
our study suggests that MEK1/2 inhibitors activate macrophage ABCG1 expression/RCT, and inhibit foam cell formation and lesion development by multiple mechanisms, supporting the concept that ERK1/2 inhibition is anti-atherogenic
miR-33 augments macrophage lipid rafts and enhances proinflammatory cytokine induction and NF-kappaB activation by LPS. This occurs through an ABCA1- and ABCG1-dependent mechanism and is reversible by interventions upon raft cholesterol and by ABC transporter-inducing liver X receptor agonists.
ABCG1 expression was down-regulated by TLR4 (zeige TLR4 Proteine), which induces inflammation and lipid accumulation in vascular smooth muscle cells via PPARgamma (zeige PPARG Proteine)/LXRalpha (zeige NR1H3 Proteine) signaling.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified.
ATP-binding cassette sub-family G member 1
, ATP-binding cassette, sub-family G (WHITE), member 1
, ATP-binding cassette sub-family G member 1-like
, ABC transporter 8
, ATP-binding cassette transporter 8
, ATP-binding cassette transporter member 1 of subfamily G
, homolog of Drosophila white
, white protein homolog (ATP-binding cassette transporter 8)
, ATP-binding cassette 8
, ATP-binding cassette, subfamily G, member 1
, white protein homolog