Leptin Proteine
(Leptin (LEP))
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008].
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LEP
Spezies: Maus
Wirt: Escherichia coli (E. coli)
Recombinant
< 98 % by SDS-PAGE gel and HPLC analyses.
Active
LEP
Spezies: Rind (Kuh)
Wirt: Hefe
Recombinant
> 90 %
ELISA
LEP
Spezies: Takifugu rubripes
Wirt: Hefe
Recombinant
> 90 %
ELISA
LEP
Spezies: Tetraodon nigroviridis
Wirt: Hefe
Recombinant
> 90 %
ELISA
LEP
Spezies: Rhesusaffen
Wirt: Hefe
Recombinant
> 90 %
ELISA
Aktuelle Publikationen für unsere Leptin Proteine
: "The effects of adipokines on cartilage and meniscus catabolism." in: Connective tissue research, Vol. 52, Issue 6, pp. 523-33, (2012) (PubMed).: "Leptin and amylin act in an additive manner to activate overlapping signaling pathways in peripheral tissues: in vitro and ex vivo studies in humans." in: Diabetes Care, Vol. 34, Issue 1, pp. 132-8, (2011) (PubMed).
: "Effects of orexigenic peptides and leptin on melatonin secretion during different photoperiods in seasonal breeding ewes: an in vitro study." in: Domestic animal endocrinology, Vol. 40, Issue 3, pp. 139-46, (2011) (PubMed).
: "Effect of bupivacaine on sevoflurane-induced preconditioning in isolated rat hearts." in: European journal of pharmacology, Vol. 647, Issue 1-3, pp. 132-8, (2010) (PubMed).
: "Seasonal effects of central leptin infusion and prolactin treatment on pituitary SOCS-3 gene expression in ewes." in: The Journal of endocrinology, Vol. 208, Issue 1, pp. 81-8, (2010) (PubMed).
: "The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system." in: Endocrinology, Vol. 150, Issue 11, pp. 5016-26, (2009) (PubMed).
: "Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats." in: Diabetes, Vol. 55, Issue 9, pp. 2602-10, (2006) (PubMed).
: "Leptin concentrations in maternal serum and amniotic fluid during the second trimenon: differential relation to fetal gender and maternal morphometry." in: European journal of obstetrics, gynecology, and reproductive biology, Vol. 86, Issue 2, pp. 151-7, (1999) (PubMed).
: "Genomic structure and promoter analysis of the human obese gene." in: The Journal of biological chemistry, Vol. 271, Issue 8, pp. 3971-4, (1996) (PubMed).
: "Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue." in: Diabetes, Vol. 44, Issue 7, pp. 855-8, (1995) (PubMed).
Aliase für Leptin Proteine
leptin (Lep) Proteineleptin (LEP) Proteine
leptin (lep) Proteine
LEPD Proteine
ob Proteine
OB Proteine
obese Proteine
OBS Proteine
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